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Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging
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| Zeitschriftentitel: | Journal of Cerebral Blood Flow & Metabolism |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Cerebral Blood Flow & Metabolism, 32, 2012, 8, S. 1508-1514 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
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| Schlagwörter: |
| author_facet |
Butt, Sadia A Søgaard, Lise V Magnusson, Peter O Lauritzen, Mette H Laustsen, Christoffer Åkeson, Per Ardenkjær-Larsen, Jan H Butt, Sadia A Søgaard, Lise V Magnusson, Peter O Lauritzen, Mette H Laustsen, Christoffer Åkeson, Per Ardenkjær-Larsen, Jan H |
|---|---|
| author |
Butt, Sadia A Søgaard, Lise V Magnusson, Peter O Lauritzen, Mette H Laustsen, Christoffer Åkeson, Per Ardenkjær-Larsen, Jan H |
| spellingShingle |
Butt, Sadia A Søgaard, Lise V Magnusson, Peter O Lauritzen, Mette H Laustsen, Christoffer Åkeson, Per Ardenkjær-Larsen, Jan H Journal of Cerebral Blood Flow & Metabolism Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
| author_sort |
butt, sadia a |
| spelling |
Butt, Sadia A Søgaard, Lise V Magnusson, Peter O Lauritzen, Mette H Laustsen, Christoffer Åkeson, Per Ardenkjær-Larsen, Jan H 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1038/jcbfm.2012.34 <jats:p> The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1-<jats:sup>13</jats:sup>C]isocaproate (KIC) in the normal rat using magnetic resonance modalities. Hyperpolarized KIC is metabolized to [1-<jats:sup>13</jats:sup>C]leucine (leucine) by BCAT. The results show that KIC and its metabolic product, leucine, are present at imageable quantities 20 seconds after end of KIC administration throughout the brain. Further, significantly higher metabolism was observed in hippocampal regions compared with the muscle tissue. In conclusion, the cerebral metabolism of hyperpolarized KIC is imaged and hyperpolarized KIC may be a promising substrate for evaluation of cerebral BCAT activity in conjunction with neurodegenerative disease. </jats:p> Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopic Imaging Journal of Cerebral Blood Flow & Metabolism |
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SAGE Publications, 2012 |
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| title |
Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_unstemmed |
Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_full |
Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_fullStr |
Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_full_unstemmed |
Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_short |
Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_sort |
imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized <sup>13</sup>c magnetic resonance spectroscopic imaging |
| topic |
Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
| url |
http://dx.doi.org/10.1038/jcbfm.2012.34 |
| publishDate |
2012 |
| physical |
1508-1514 |
| description |
<jats:p> The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1-<jats:sup>13</jats:sup>C]isocaproate (KIC) in the normal rat using magnetic resonance modalities. Hyperpolarized KIC is metabolized to [1-<jats:sup>13</jats:sup>C]leucine (leucine) by BCAT. The results show that KIC and its metabolic product, leucine, are present at imageable quantities 20 seconds after end of KIC administration throughout the brain. Further, significantly higher metabolism was observed in hippocampal regions compared with the muscle tissue. In conclusion, the cerebral metabolism of hyperpolarized KIC is imaged and hyperpolarized KIC may be a promising substrate for evaluation of cerebral BCAT activity in conjunction with neurodegenerative disease. </jats:p> |
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| author | Butt, Sadia A, Søgaard, Lise V, Magnusson, Peter O, Lauritzen, Mette H, Laustsen, Christoffer, Åkeson, Per, Ardenkjær-Larsen, Jan H |
| author_facet | Butt, Sadia A, Søgaard, Lise V, Magnusson, Peter O, Lauritzen, Mette H, Laustsen, Christoffer, Åkeson, Per, Ardenkjær-Larsen, Jan H, Butt, Sadia A, Søgaard, Lise V, Magnusson, Peter O, Lauritzen, Mette H, Laustsen, Christoffer, Åkeson, Per, Ardenkjær-Larsen, Jan H |
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| description | <jats:p> The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1-<jats:sup>13</jats:sup>C]isocaproate (KIC) in the normal rat using magnetic resonance modalities. Hyperpolarized KIC is metabolized to [1-<jats:sup>13</jats:sup>C]leucine (leucine) by BCAT. The results show that KIC and its metabolic product, leucine, are present at imageable quantities 20 seconds after end of KIC administration throughout the brain. Further, significantly higher metabolism was observed in hippocampal regions compared with the muscle tissue. In conclusion, the cerebral metabolism of hyperpolarized KIC is imaged and hyperpolarized KIC may be a promising substrate for evaluation of cerebral BCAT activity in conjunction with neurodegenerative disease. </jats:p> |
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| imprint | SAGE Publications, 2012 |
| imprint_str_mv | SAGE Publications, 2012 |
| institution | DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3 |
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| spelling | Butt, Sadia A Søgaard, Lise V Magnusson, Peter O Lauritzen, Mette H Laustsen, Christoffer Åkeson, Per Ardenkjær-Larsen, Jan H 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1038/jcbfm.2012.34 <jats:p> The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1-<jats:sup>13</jats:sup>C]isocaproate (KIC) in the normal rat using magnetic resonance modalities. Hyperpolarized KIC is metabolized to [1-<jats:sup>13</jats:sup>C]leucine (leucine) by BCAT. The results show that KIC and its metabolic product, leucine, are present at imageable quantities 20 seconds after end of KIC administration throughout the brain. Further, significantly higher metabolism was observed in hippocampal regions compared with the muscle tissue. In conclusion, the cerebral metabolism of hyperpolarized KIC is imaged and hyperpolarized KIC may be a promising substrate for evaluation of cerebral BCAT activity in conjunction with neurodegenerative disease. </jats:p> Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopic Imaging Journal of Cerebral Blood Flow & Metabolism |
| spellingShingle | Butt, Sadia A, Søgaard, Lise V, Magnusson, Peter O, Lauritzen, Mette H, Laustsen, Christoffer, Åkeson, Per, Ardenkjær-Larsen, Jan H, Journal of Cerebral Blood Flow & Metabolism, Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging, Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| title | Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_full | Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_fullStr | Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_full_unstemmed | Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_short | Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| title_sort | imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized <sup>13</sup>c magnetic resonance spectroscopic imaging |
| title_unstemmed | Imaging Cerebral 2-Ketoisocaproate Metabolism with Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging |
| topic | Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| url | http://dx.doi.org/10.1038/jcbfm.2012.34 |