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Glucose Modulation of Spreading Depression Susceptibility
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| Zeitschriftentitel: | Journal of Cerebral Blood Flow & Metabolism |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Cerebral Blood Flow & Metabolism, 33, 2013, 2, S. 191-195 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
SAGE Publications
|
| Schlagwörter: |
| author_facet |
Hoffmann, Ulrike Sukhotinsky, Inna Eikermann-Haerter, Katharina Ayata, Cenk Hoffmann, Ulrike Sukhotinsky, Inna Eikermann-Haerter, Katharina Ayata, Cenk |
|---|---|
| author |
Hoffmann, Ulrike Sukhotinsky, Inna Eikermann-Haerter, Katharina Ayata, Cenk |
| spellingShingle |
Hoffmann, Ulrike Sukhotinsky, Inna Eikermann-Haerter, Katharina Ayata, Cenk Journal of Cerebral Blood Flow & Metabolism Glucose Modulation of Spreading Depression Susceptibility Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
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hoffmann, ulrike |
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Hoffmann, Ulrike Sukhotinsky, Inna Eikermann-Haerter, Katharina Ayata, Cenk 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1038/jcbfm.2012.132 <jats:p> Spreading depression of Leão is an intense spreading depolarization (SD) wave associated with massive transmembrane ionic, water, and neurotransmitter shifts. Spreading depolarization underlies migraine aura, and occurs in brain injury, making it a potential therapeutic target. While susceptibility to SD can be modulated pharmacologically, much less is known about modulation by systemic physiological factors, such as the glycemic state. In this study, we systematically examined modulation of SD susceptibility by blood glucose in anesthetized rats under full physiological monitoring. Hyperglycemia and hypoglycemia were induced by insulin or dextrose infusion (blood glucose ~40 and 400 mg/dL, respectively). Spreading depolarizations were evoked by direct cortical electrical stimulation to determine the intensity threshold, or by continuous topical KCl application to determine SD frequency. Hyperglycemia elevated the electrical SD threshold and reduced the frequency of KCl-induced SDs, without significantly affecting other SD properties. In contrast, hypoglycemia significantly prolonged individual and cumulative SD durations, but did not alter the electrical SD threshold, or SD frequency, amplitude or propagation speed. These data show that increased cerebral glucose availability makes the tissue resistant to SD. </jats:p> Glucose Modulation of Spreading Depression Susceptibility Journal of Cerebral Blood Flow & Metabolism |
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Glucose Modulation of Spreading Depression Susceptibility |
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Glucose Modulation of Spreading Depression Susceptibility |
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Glucose Modulation of Spreading Depression Susceptibility |
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Glucose Modulation of Spreading Depression Susceptibility |
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Glucose Modulation of Spreading Depression Susceptibility |
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glucose modulation of spreading depression susceptibility |
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Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology |
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http://dx.doi.org/10.1038/jcbfm.2012.132 |
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2013 |
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191-195 |
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<jats:p> Spreading depression of Leão is an intense spreading depolarization (SD) wave associated with massive transmembrane ionic, water, and neurotransmitter shifts. Spreading depolarization underlies migraine aura, and occurs in brain injury, making it a potential therapeutic target. While susceptibility to SD can be modulated pharmacologically, much less is known about modulation by systemic physiological factors, such as the glycemic state. In this study, we systematically examined modulation of SD susceptibility by blood glucose in anesthetized rats under full physiological monitoring. Hyperglycemia and hypoglycemia were induced by insulin or dextrose infusion (blood glucose ~40 and 400 mg/dL, respectively). Spreading depolarizations were evoked by direct cortical electrical stimulation to determine the intensity threshold, or by continuous topical KCl application to determine SD frequency. Hyperglycemia elevated the electrical SD threshold and reduced the frequency of KCl-induced SDs, without significantly affecting other SD properties. In contrast, hypoglycemia significantly prolonged individual and cumulative SD durations, but did not alter the electrical SD threshold, or SD frequency, amplitude or propagation speed. These data show that increased cerebral glucose availability makes the tissue resistant to SD. </jats:p> |
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| description | <jats:p> Spreading depression of Leão is an intense spreading depolarization (SD) wave associated with massive transmembrane ionic, water, and neurotransmitter shifts. Spreading depolarization underlies migraine aura, and occurs in brain injury, making it a potential therapeutic target. While susceptibility to SD can be modulated pharmacologically, much less is known about modulation by systemic physiological factors, such as the glycemic state. In this study, we systematically examined modulation of SD susceptibility by blood glucose in anesthetized rats under full physiological monitoring. Hyperglycemia and hypoglycemia were induced by insulin or dextrose infusion (blood glucose ~40 and 400 mg/dL, respectively). Spreading depolarizations were evoked by direct cortical electrical stimulation to determine the intensity threshold, or by continuous topical KCl application to determine SD frequency. Hyperglycemia elevated the electrical SD threshold and reduced the frequency of KCl-induced SDs, without significantly affecting other SD properties. In contrast, hypoglycemia significantly prolonged individual and cumulative SD durations, but did not alter the electrical SD threshold, or SD frequency, amplitude or propagation speed. These data show that increased cerebral glucose availability makes the tissue resistant to SD. </jats:p> |
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| spelling | Hoffmann, Ulrike Sukhotinsky, Inna Eikermann-Haerter, Katharina Ayata, Cenk 0271-678X 1559-7016 SAGE Publications Cardiology and Cardiovascular Medicine Neurology (clinical) Neurology http://dx.doi.org/10.1038/jcbfm.2012.132 <jats:p> Spreading depression of Leão is an intense spreading depolarization (SD) wave associated with massive transmembrane ionic, water, and neurotransmitter shifts. Spreading depolarization underlies migraine aura, and occurs in brain injury, making it a potential therapeutic target. While susceptibility to SD can be modulated pharmacologically, much less is known about modulation by systemic physiological factors, such as the glycemic state. In this study, we systematically examined modulation of SD susceptibility by blood glucose in anesthetized rats under full physiological monitoring. Hyperglycemia and hypoglycemia were induced by insulin or dextrose infusion (blood glucose ~40 and 400 mg/dL, respectively). Spreading depolarizations were evoked by direct cortical electrical stimulation to determine the intensity threshold, or by continuous topical KCl application to determine SD frequency. Hyperglycemia elevated the electrical SD threshold and reduced the frequency of KCl-induced SDs, without significantly affecting other SD properties. In contrast, hypoglycemia significantly prolonged individual and cumulative SD durations, but did not alter the electrical SD threshold, or SD frequency, amplitude or propagation speed. These data show that increased cerebral glucose availability makes the tissue resistant to SD. </jats:p> Glucose Modulation of Spreading Depression Susceptibility Journal of Cerebral Blood Flow & Metabolism |
| spellingShingle | Hoffmann, Ulrike, Sukhotinsky, Inna, Eikermann-Haerter, Katharina, Ayata, Cenk, Journal of Cerebral Blood Flow & Metabolism, Glucose Modulation of Spreading Depression Susceptibility, Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| title | Glucose Modulation of Spreading Depression Susceptibility |
| title_full | Glucose Modulation of Spreading Depression Susceptibility |
| title_fullStr | Glucose Modulation of Spreading Depression Susceptibility |
| title_full_unstemmed | Glucose Modulation of Spreading Depression Susceptibility |
| title_short | Glucose Modulation of Spreading Depression Susceptibility |
| title_sort | glucose modulation of spreading depression susceptibility |
| title_unstemmed | Glucose Modulation of Spreading Depression Susceptibility |
| topic | Cardiology and Cardiovascular Medicine, Neurology (clinical), Neurology |
| url | http://dx.doi.org/10.1038/jcbfm.2012.132 |