Eintrag weiter verarbeiten
The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes
Gespeichert in:
| Zeitschriftentitel: | Immunology & Cell Biology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Immunology & Cell Biology, 87, 2009, 1, S. 16-19 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Pillai, Shiv Cariappa, Annaiah Pillai, Shiv Cariappa, Annaiah |
|---|---|
| author |
Pillai, Shiv Cariappa, Annaiah |
| spellingShingle |
Pillai, Shiv Cariappa, Annaiah Immunology & Cell Biology The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes Cell Biology Immunology Immunology and Allergy |
| author_sort |
pillai, shiv |
| spelling |
Pillai, Shiv Cariappa, Annaiah 0818-9641 1440-1711 Wiley Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1038/icb.2008.89 <jats:p>A unique ‘second’ niche for follicular B cells has been described in the extravascular compartment of the bone marrow surrounding vascular sinusoids. The occupancy of this niche by B cells presumably evolved to facilitate humoral immune responses to blood‐borne pathogens. B cells appear to be sustained in this niche by bone marrow dendritic cells and are lost from this compartment in certain mutant mice. We discuss here what is known regarding the mechanisms of entry and egress of B cells from the perisinusoidal niche and also consider the function of the bone marrow as a secondary lymphoid organ. Although immature B cells can mature into follicular B cells in this niche as well as in the spleen, the lineage commitment event that accompanies positive selection of B cells occurs only in the spleen.</jats:p> The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes Immunology & Cell Biology |
| doi_str_mv |
10.1038/icb.2008.89 |
| facet_avail |
Online |
| finc_class_facet |
Biologie Medizin |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOC9pY2IuMjAwOC44OQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOC9pY2IuMjAwOC44OQ |
| institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
| imprint |
Wiley, 2009 |
| imprint_str_mv |
Wiley, 2009 |
| issn |
0818-9641 1440-1711 |
| issn_str_mv |
0818-9641 1440-1711 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
pillai2009thebonemarrowperisinusoidalnicheforrecirculatingbcellsandthepositiveselectionofbonemarrowderivedblymphocytes |
| publishDateSort |
2009 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Immunology & Cell Biology |
| source_id |
49 |
| title |
The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_unstemmed |
The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_full |
The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_fullStr |
The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_full_unstemmed |
The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_short |
The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_sort |
the bone marrow perisinusoidal niche for recirculating b cells and the positive selection of bone marrow‐derived b lymphocytes |
| topic |
Cell Biology Immunology Immunology and Allergy |
| url |
http://dx.doi.org/10.1038/icb.2008.89 |
| publishDate |
2009 |
| physical |
16-19 |
| description |
<jats:p>A unique ‘second’ niche for follicular B cells has been described in the extravascular compartment of the bone marrow surrounding vascular sinusoids. The occupancy of this niche by B cells presumably evolved to facilitate humoral immune responses to blood‐borne pathogens. B cells appear to be sustained in this niche by bone marrow dendritic cells and are lost from this compartment in certain mutant mice. We discuss here what is known regarding the mechanisms of entry and egress of B cells from the perisinusoidal niche and also consider the function of the bone marrow as a secondary lymphoid organ. Although immature B cells can mature into follicular B cells in this niche as well as in the spleen, the lineage commitment event that accompanies positive selection of B cells occurs only in the spleen.</jats:p> |
| container_issue |
1 |
| container_start_page |
16 |
| container_title |
Immunology & Cell Biology |
| container_volume |
87 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792339142434095106 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:43:26.185Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=The+bone+marrow+perisinusoidal+niche+for+recirculating+B+cells+and+the+positive+selection+of+bone+marrow%E2%80%90derived+B+lymphocytes&rft.date=2009-01-01&genre=article&issn=1440-1711&volume=87&issue=1&spage=16&epage=19&pages=16-19&jtitle=Immunology+%26+Cell+Biology&atitle=The+bone+marrow+perisinusoidal+niche+for+recirculating+B+cells+and+the+positive+selection+of+bone+marrow%E2%80%90derived+B+lymphocytes&aulast=Cariappa&aufirst=Annaiah&rft_id=info%3Adoi%2F10.1038%2Ficb.2008.89&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792339142434095106 |
| author | Pillai, Shiv, Cariappa, Annaiah |
| author_facet | Pillai, Shiv, Cariappa, Annaiah, Pillai, Shiv, Cariappa, Annaiah |
| author_sort | pillai, shiv |
| container_issue | 1 |
| container_start_page | 16 |
| container_title | Immunology & Cell Biology |
| container_volume | 87 |
| description | <jats:p>A unique ‘second’ niche for follicular B cells has been described in the extravascular compartment of the bone marrow surrounding vascular sinusoids. The occupancy of this niche by B cells presumably evolved to facilitate humoral immune responses to blood‐borne pathogens. B cells appear to be sustained in this niche by bone marrow dendritic cells and are lost from this compartment in certain mutant mice. We discuss here what is known regarding the mechanisms of entry and egress of B cells from the perisinusoidal niche and also consider the function of the bone marrow as a secondary lymphoid organ. Although immature B cells can mature into follicular B cells in this niche as well as in the spleen, the lineage commitment event that accompanies positive selection of B cells occurs only in the spleen.</jats:p> |
| doi_str_mv | 10.1038/icb.2008.89 |
| facet_avail | Online |
| finc_class_facet | Biologie, Medizin |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOC9pY2IuMjAwOC44OQ |
| imprint | Wiley, 2009 |
| imprint_str_mv | Wiley, 2009 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0818-9641, 1440-1711 |
| issn_str_mv | 0818-9641, 1440-1711 |
| language | English |
| last_indexed | 2024-03-01T15:43:26.185Z |
| match_str | pillai2009thebonemarrowperisinusoidalnicheforrecirculatingbcellsandthepositiveselectionofbonemarrowderivedblymphocytes |
| mega_collection | Wiley (CrossRef) |
| physical | 16-19 |
| publishDate | 2009 |
| publishDateSort | 2009 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Immunology & Cell Biology |
| source_id | 49 |
| spelling | Pillai, Shiv Cariappa, Annaiah 0818-9641 1440-1711 Wiley Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1038/icb.2008.89 <jats:p>A unique ‘second’ niche for follicular B cells has been described in the extravascular compartment of the bone marrow surrounding vascular sinusoids. The occupancy of this niche by B cells presumably evolved to facilitate humoral immune responses to blood‐borne pathogens. B cells appear to be sustained in this niche by bone marrow dendritic cells and are lost from this compartment in certain mutant mice. We discuss here what is known regarding the mechanisms of entry and egress of B cells from the perisinusoidal niche and also consider the function of the bone marrow as a secondary lymphoid organ. Although immature B cells can mature into follicular B cells in this niche as well as in the spleen, the lineage commitment event that accompanies positive selection of B cells occurs only in the spleen.</jats:p> The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes Immunology & Cell Biology |
| spellingShingle | Pillai, Shiv, Cariappa, Annaiah, Immunology & Cell Biology, The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes, Cell Biology, Immunology, Immunology and Allergy |
| title | The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_full | The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_fullStr | The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_full_unstemmed | The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_short | The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| title_sort | the bone marrow perisinusoidal niche for recirculating b cells and the positive selection of bone marrow‐derived b lymphocytes |
| title_unstemmed | The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow‐derived B lymphocytes |
| topic | Cell Biology, Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1038/icb.2008.89 |