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Protective immunity to liver‐stage malaria
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| Zeitschriftentitel: | Clinical & Translational Immunology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Clinical & Translational Immunology, 5, 2016, 10 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
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Holz, Lauren E Fernandez‐Ruiz, Daniel Heath, William R Holz, Lauren E Fernandez‐Ruiz, Daniel Heath, William R |
|---|---|
| author |
Holz, Lauren E Fernandez‐Ruiz, Daniel Heath, William R |
| spellingShingle |
Holz, Lauren E Fernandez‐Ruiz, Daniel Heath, William R Clinical & Translational Immunology Protective immunity to liver‐stage malaria General Nursing Immunology Immunology and Allergy |
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holz, lauren e |
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Holz, Lauren E Fernandez‐Ruiz, Daniel Heath, William R 2050-0068 2050-0068 Wiley General Nursing Immunology Immunology and Allergy http://dx.doi.org/10.1038/cti.2016.60 <jats:p>Despite decades of research and recent clinical trials, an efficacious long‐lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the liver acts as a bottleneck to blood‐stage infection, it represents a potential site for parasite and disease control. In this review, we discuss immunity to liver‐stage malaria. It is hoped that the knowledge gained from animal models of malaria immunity will translate into a more powerful and effective vaccine to reduce this global health problem.</jats:p> Protective immunity to liver‐stage malaria Clinical & Translational Immunology |
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Clinical & Translational Immunology |
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Protective immunity to liver‐stage malaria |
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Protective immunity to liver‐stage malaria |
| title_full |
Protective immunity to liver‐stage malaria |
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Protective immunity to liver‐stage malaria |
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Protective immunity to liver‐stage malaria |
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Protective immunity to liver‐stage malaria |
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protective immunity to liver‐stage malaria |
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General Nursing Immunology Immunology and Allergy |
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http://dx.doi.org/10.1038/cti.2016.60 |
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2016 |
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<jats:p>Despite decades of research and recent clinical trials, an efficacious long‐lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the liver acts as a bottleneck to blood‐stage infection, it represents a potential site for parasite and disease control. In this review, we discuss immunity to liver‐stage malaria. It is hoped that the knowledge gained from animal models of malaria immunity will translate into a more powerful and effective vaccine to reduce this global health problem.</jats:p> |
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| author | Holz, Lauren E, Fernandez‐Ruiz, Daniel, Heath, William R |
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| description | <jats:p>Despite decades of research and recent clinical trials, an efficacious long‐lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the liver acts as a bottleneck to blood‐stage infection, it represents a potential site for parasite and disease control. In this review, we discuss immunity to liver‐stage malaria. It is hoped that the knowledge gained from animal models of malaria immunity will translate into a more powerful and effective vaccine to reduce this global health problem.</jats:p> |
| doi_str_mv | 10.1038/cti.2016.60 |
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| imprint | Wiley, 2016 |
| imprint_str_mv | Wiley, 2016 |
| institution | DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4 |
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| spelling | Holz, Lauren E Fernandez‐Ruiz, Daniel Heath, William R 2050-0068 2050-0068 Wiley General Nursing Immunology Immunology and Allergy http://dx.doi.org/10.1038/cti.2016.60 <jats:p>Despite decades of research and recent clinical trials, an efficacious long‐lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the liver acts as a bottleneck to blood‐stage infection, it represents a potential site for parasite and disease control. In this review, we discuss immunity to liver‐stage malaria. It is hoped that the knowledge gained from animal models of malaria immunity will translate into a more powerful and effective vaccine to reduce this global health problem.</jats:p> Protective immunity to liver‐stage malaria Clinical & Translational Immunology |
| spellingShingle | Holz, Lauren E, Fernandez‐Ruiz, Daniel, Heath, William R, Clinical & Translational Immunology, Protective immunity to liver‐stage malaria, General Nursing, Immunology, Immunology and Allergy |
| title | Protective immunity to liver‐stage malaria |
| title_full | Protective immunity to liver‐stage malaria |
| title_fullStr | Protective immunity to liver‐stage malaria |
| title_full_unstemmed | Protective immunity to liver‐stage malaria |
| title_short | Protective immunity to liver‐stage malaria |
| title_sort | protective immunity to liver‐stage malaria |
| title_unstemmed | Protective immunity to liver‐stage malaria |
| topic | General Nursing, Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1038/cti.2016.60 |