Eintrag weiter verarbeiten
Online-Ressource

Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel: Biotechnology Progress
Personen und Körperschaften: Blayer, Simone, Woodley, John M., Lilly, Malcolm D., Dawson, Michael J.
In: Biotechnology Progress, 12, 1996, 6, S. 758-763
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Biotechnology
author_facet Blayer, Simone
Woodley, John M.
Lilly, Malcolm D.
Dawson, Michael J.
Blayer, Simone
Woodley, John M.
Lilly, Malcolm D.
Dawson, Michael J.
author Blayer, Simone
Woodley, John M.
Lilly, Malcolm D.
Dawson, Michael J.
spellingShingle Blayer, Simone
Woodley, John M.
Lilly, Malcolm D.
Dawson, Michael J.
Biotechnology Progress
Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
Biotechnology
author_sort blayer, simone
spelling Blayer, Simone Woodley, John M. Lilly, Malcolm D. Dawson, Michael J. 8756-7938 1520-6033 Wiley Biotechnology http://dx.doi.org/10.1021/bp9600647 <jats:title>Abstract</jats:title><jats:p>The characterization of the chemoenzymatic synthesis of <jats:italic>N</jats:italic>‐acetyl‐<jats:sc>d</jats:sc>‐neuraminic acid using a base‐catalyzed epimerization and Neu5Ac aldolase‐catalyzed condensation is presented. The characterization has been used to exemplify a structured approach to biotransformation process design. In addition, the option of integration of the epimerization with the biotransformation (at alkaline pH) was considered. Process operating windows have been generated as a result of this approach, defining possible operating regions for subsequent scale‐up.</jats:p> Characterization of the Chemoenzymatic Synthesis of <i>N</i>‐Acetyl‐<scp>d</scp>‐neuraminic Acid (Neu5Ac) Biotechnology Progress
doi_str_mv 10.1021/bp9600647
facet_avail Online
finc_class_facet Biologie
Technik
format ElectronicArticle
fullrecord blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAyMS9icDk2MDA2NDc
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAyMS9icDk2MDA2NDc
institution DE-Bn3
DE-Brt1
DE-D161
DE-Gla1
DE-Zi4
DE-15
DE-Pl11
DE-Rs1
DE-105
DE-14
DE-Ch1
DE-L229
DE-D275
imprint Wiley, 1996
imprint_str_mv Wiley, 1996
issn 8756-7938
1520-6033
issn_str_mv 8756-7938
1520-6033
language English
mega_collection Wiley (CrossRef)
match_str blayer1996characterizationofthechemoenzymaticsynthesisofnacetyldneuraminicacidneu5ac
publishDateSort 1996
publisher Wiley
recordtype ai
record_format ai
series Biotechnology Progress
source_id 49
title Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_unstemmed Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_full Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_fullStr Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_full_unstemmed Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_short Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_sort characterization of the chemoenzymatic synthesis of <i>n</i>‐acetyl‐<scp>d</scp>‐neuraminic acid (neu5ac)
topic Biotechnology
url http://dx.doi.org/10.1021/bp9600647
publishDate 1996
physical 758-763
description <jats:title>Abstract</jats:title><jats:p>The characterization of the chemoenzymatic synthesis of <jats:italic>N</jats:italic>‐acetyl‐<jats:sc>d</jats:sc>‐neuraminic acid using a base‐catalyzed epimerization and Neu5Ac aldolase‐catalyzed condensation is presented. The characterization has been used to exemplify a structured approach to biotransformation process design. In addition, the option of integration of the epimerization with the biotransformation (at alkaline pH) was considered. Process operating windows have been generated as a result of this approach, defining possible operating regions for subsequent scale‐up.</jats:p>
container_issue 6
container_start_page 758
container_title Biotechnology Progress
container_volume 12
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
_version_ 1792335798848192512
geogr_code not assigned
last_indexed 2024-03-01T14:50:17.367Z
geogr_code_person not assigned
openURL url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Characterization+of+the+Chemoenzymatic+Synthesis+of+N%E2%80%90Acetyl%E2%80%90d%E2%80%90neuraminic+Acid+%28Neu5Ac%29&rft.date=1996-01-01&genre=article&issn=1520-6033&volume=12&issue=6&spage=758&epage=763&pages=758-763&jtitle=Biotechnology+Progress&atitle=Characterization+of+the+Chemoenzymatic+Synthesis+of+%3Ci%3EN%3C%2Fi%3E%E2%80%90Acetyl%E2%80%90%3Cscp%3Ed%3C%2Fscp%3E%E2%80%90neuraminic+Acid+%28Neu5Ac%29&aulast=Dawson&aufirst=Michael+J.&rft_id=info%3Adoi%2F10.1021%2Fbp9600647&rft.language%5B0%5D=eng
SOLR
_version_ 1792335798848192512
author Blayer, Simone, Woodley, John M., Lilly, Malcolm D., Dawson, Michael J.
author_facet Blayer, Simone, Woodley, John M., Lilly, Malcolm D., Dawson, Michael J., Blayer, Simone, Woodley, John M., Lilly, Malcolm D., Dawson, Michael J.
author_sort blayer, simone
container_issue 6
container_start_page 758
container_title Biotechnology Progress
container_volume 12
description <jats:title>Abstract</jats:title><jats:p>The characterization of the chemoenzymatic synthesis of <jats:italic>N</jats:italic>‐acetyl‐<jats:sc>d</jats:sc>‐neuraminic acid using a base‐catalyzed epimerization and Neu5Ac aldolase‐catalyzed condensation is presented. The characterization has been used to exemplify a structured approach to biotransformation process design. In addition, the option of integration of the epimerization with the biotransformation (at alkaline pH) was considered. Process operating windows have been generated as a result of this approach, defining possible operating regions for subsequent scale‐up.</jats:p>
doi_str_mv 10.1021/bp9600647
facet_avail Online
finc_class_facet Biologie, Technik
format ElectronicArticle
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAyMS9icDk2MDA2NDc
imprint Wiley, 1996
imprint_str_mv Wiley, 1996
institution DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275
issn 8756-7938, 1520-6033
issn_str_mv 8756-7938, 1520-6033
language English
last_indexed 2024-03-01T14:50:17.367Z
match_str blayer1996characterizationofthechemoenzymaticsynthesisofnacetyldneuraminicacidneu5ac
mega_collection Wiley (CrossRef)
physical 758-763
publishDate 1996
publishDateSort 1996
publisher Wiley
record_format ai
recordtype ai
series Biotechnology Progress
source_id 49
spelling Blayer, Simone Woodley, John M. Lilly, Malcolm D. Dawson, Michael J. 8756-7938 1520-6033 Wiley Biotechnology http://dx.doi.org/10.1021/bp9600647 <jats:title>Abstract</jats:title><jats:p>The characterization of the chemoenzymatic synthesis of <jats:italic>N</jats:italic>‐acetyl‐<jats:sc>d</jats:sc>‐neuraminic acid using a base‐catalyzed epimerization and Neu5Ac aldolase‐catalyzed condensation is presented. The characterization has been used to exemplify a structured approach to biotransformation process design. In addition, the option of integration of the epimerization with the biotransformation (at alkaline pH) was considered. Process operating windows have been generated as a result of this approach, defining possible operating regions for subsequent scale‐up.</jats:p> Characterization of the Chemoenzymatic Synthesis of <i>N</i>‐Acetyl‐<scp>d</scp>‐neuraminic Acid (Neu5Ac) Biotechnology Progress
spellingShingle Blayer, Simone, Woodley, John M., Lilly, Malcolm D., Dawson, Michael J., Biotechnology Progress, Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac), Biotechnology
title Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_full Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_fullStr Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_full_unstemmed Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_short Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
title_sort characterization of the chemoenzymatic synthesis of <i>n</i>‐acetyl‐<scp>d</scp>‐neuraminic acid (neu5ac)
title_unstemmed Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac)
topic Biotechnology
url http://dx.doi.org/10.1021/bp9600647