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Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ...
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| Zeitschriftentitel: | Journal of Medicinal Chemistry |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Journal of Medicinal Chemistry, 62, 2019, 2, S. 561-574 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Chemical Society (ACS)
|
| Schlagwörter: |
| author_facet |
Zheng, Yi Obeng, Samuel Wang, Huiqun Jali, Abdulmajeed M. Peddibhotla, Bharath Williams, Dwight A. Zou, Chuanchun Stevens, David L. Dewey, William L. Akbarali, Hamid I. Selley, Dana E. Zhang, Yan Zheng, Yi Obeng, Samuel Wang, Huiqun Jali, Abdulmajeed M. Peddibhotla, Bharath Williams, Dwight A. Zou, Chuanchun Stevens, David L. Dewey, William L. Akbarali, Hamid I. Selley, Dana E. Zhang, Yan |
|---|---|
| author |
Zheng, Yi Obeng, Samuel Wang, Huiqun Jali, Abdulmajeed M. Peddibhotla, Bharath Williams, Dwight A. Zou, Chuanchun Stevens, David L. Dewey, William L. Akbarali, Hamid I. Selley, Dana E. Zhang, Yan |
| spellingShingle |
Zheng, Yi Obeng, Samuel Wang, Huiqun Jali, Abdulmajeed M. Peddibhotla, Bharath Williams, Dwight A. Zou, Chuanchun Stevens, David L. Dewey, William L. Akbarali, Hamid I. Selley, Dana E. Zhang, Yan Journal of Medicinal Chemistry Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands Drug Discovery Molecular Medicine |
| author_sort |
zheng, yi |
| spelling |
Zheng, Yi Obeng, Samuel Wang, Huiqun Jali, Abdulmajeed M. Peddibhotla, Bharath Williams, Dwight A. Zou, Chuanchun Stevens, David L. Dewey, William L. Akbarali, Hamid I. Selley, Dana E. Zhang, Yan 0022-2623 1520-4804 American Chemical Society (ACS) Drug Discovery Molecular Medicine http://dx.doi.org/10.1021/acs.jmedchem.8b01158 Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands Journal of Medicinal Chemistry |
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10.1021/acs.jmedchem.8b01158 |
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American Chemical Society (ACS), 2019 |
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American Chemical Society (ACS) |
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Journal of Medicinal Chemistry |
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| title |
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_unstemmed |
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_full |
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_fullStr |
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_full_unstemmed |
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_short |
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_sort |
design, synthesis, and biological evaluation of the third generation 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (nap) derivatives as μ/κ opioid receptor dual selective ligands |
| topic |
Drug Discovery Molecular Medicine |
| url |
http://dx.doi.org/10.1021/acs.jmedchem.8b01158 |
| publishDate |
2019 |
| physical |
561-574 |
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| author | Zheng, Yi, Obeng, Samuel, Wang, Huiqun, Jali, Abdulmajeed M., Peddibhotla, Bharath, Williams, Dwight A., Zou, Chuanchun, Stevens, David L., Dewey, William L., Akbarali, Hamid I., Selley, Dana E., Zhang, Yan |
| author_facet | Zheng, Yi, Obeng, Samuel, Wang, Huiqun, Jali, Abdulmajeed M., Peddibhotla, Bharath, Williams, Dwight A., Zou, Chuanchun, Stevens, David L., Dewey, William L., Akbarali, Hamid I., Selley, Dana E., Zhang, Yan, Zheng, Yi, Obeng, Samuel, Wang, Huiqun, Jali, Abdulmajeed M., Peddibhotla, Bharath, Williams, Dwight A., Zou, Chuanchun, Stevens, David L., Dewey, William L., Akbarali, Hamid I., Selley, Dana E., Zhang, Yan |
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| spelling | Zheng, Yi Obeng, Samuel Wang, Huiqun Jali, Abdulmajeed M. Peddibhotla, Bharath Williams, Dwight A. Zou, Chuanchun Stevens, David L. Dewey, William L. Akbarali, Hamid I. Selley, Dana E. Zhang, Yan 0022-2623 1520-4804 American Chemical Society (ACS) Drug Discovery Molecular Medicine http://dx.doi.org/10.1021/acs.jmedchem.8b01158 Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands Journal of Medicinal Chemistry |
| spellingShingle | Zheng, Yi, Obeng, Samuel, Wang, Huiqun, Jali, Abdulmajeed M., Peddibhotla, Bharath, Williams, Dwight A., Zou, Chuanchun, Stevens, David L., Dewey, William L., Akbarali, Hamid I., Selley, Dana E., Zhang, Yan, Journal of Medicinal Chemistry, Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands, Drug Discovery, Molecular Medicine |
| title | Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_full | Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_fullStr | Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_full_unstemmed | Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_short | Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| title_sort | design, synthesis, and biological evaluation of the third generation 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (nap) derivatives as μ/κ opioid receptor dual selective ligands |
| title_unstemmed | Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands |
| topic | Drug Discovery, Molecular Medicine |
| url | http://dx.doi.org/10.1021/acs.jmedchem.8b01158 |