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Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study
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| Zeitschriftentitel: | International Journal of Neuropsychopharmacology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | International Journal of Neuropsychopharmacology, 16, 2013, 5, S. 997-1008 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
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| Schlagwörter: |
| author_facet |
Kushnir, Vladyslav Menon, Mahesh Balducci, Xavier L. Selby, Peter Busto, Usoa Zawertailo, Laurie Kushnir, Vladyslav Menon, Mahesh Balducci, Xavier L. Selby, Peter Busto, Usoa Zawertailo, Laurie |
|---|---|
| author |
Kushnir, Vladyslav Menon, Mahesh Balducci, Xavier L. Selby, Peter Busto, Usoa Zawertailo, Laurie |
| spellingShingle |
Kushnir, Vladyslav Menon, Mahesh Balducci, Xavier L. Selby, Peter Busto, Usoa Zawertailo, Laurie International Journal of Neuropsychopharmacology Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study Pharmacology (medical) Psychiatry and Mental health Pharmacology |
| author_sort |
kushnir, vladyslav |
| spelling |
Kushnir, Vladyslav Menon, Mahesh Balducci, Xavier L. Selby, Peter Busto, Usoa Zawertailo, Laurie 1469-5111 1461-1457 Oxford University Press (OUP) Pharmacology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1017/s1461145710000696 <jats:title>Abstract</jats:title> <jats:p>The association between cigarette smoking and depression has been well documented; however, little research has been done to elucidate the neurobiological substrates of this highly prevalent comorbidity. We used multiple linear regression analysis to evaluate the relationship between depression severity as assessed by the Hamilton Depression Rating Scale (HAMD) and blood oxygen level-dependent (BOLD) responses to visual smoking cues in drug-free nicotine-dependent smokers (n=18). Two functional magnetic resonance imaging (fMRI) scans were completed over a single study day, following overnight smoking abstinence (pre-smoking scan) and after cigarette reinstatement (post-smoking scan). During the pre-smoking scan positive correlations between BOLD activity and HAMD scores were observed in areas of the mesocorticolimbic dopaminergic system [inferior frontal gyrus, middle frontal gyrus (MFG), hippocampus (HC), anterior cingulate gyrus] and areas of the visuospatial attention circuit (medial occipital lobe, middle cingulate cortex, superior frontal gyrus, angular gyrus). During the post-smoking scan positive correlations were observed in areas of the brain implicated in drug expectancy (MFG), memory (HC), attentional motivation (posterior cingulate cortex), and visual processing and attention (precuneus). These preliminary findings demonstrate that smokers with higher depression severity attribute greater incentive salience to smoking-related cues and this is especially pronounced during periods of acute abstinence. Such enhanced salience of smoking cues, even after smoking a cigarette, may play a critical role both in the maintenance of smoking in depression and in greater levels of nicotine dependence seen in this patient population.</jats:p> Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study International Journal of Neuropsychopharmacology |
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Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_unstemmed |
Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_full |
Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_fullStr |
Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_full_unstemmed |
Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_short |
Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_sort |
enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fmri study |
| topic |
Pharmacology (medical) Psychiatry and Mental health Pharmacology |
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http://dx.doi.org/10.1017/s1461145710000696 |
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2013 |
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997-1008 |
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<jats:title>Abstract</jats:title>
<jats:p>The association between cigarette smoking and depression has been well documented; however, little research has been done to elucidate the neurobiological substrates of this highly prevalent comorbidity. We used multiple linear regression analysis to evaluate the relationship between depression severity as assessed by the Hamilton Depression Rating Scale (HAMD) and blood oxygen level-dependent (BOLD) responses to visual smoking cues in drug-free nicotine-dependent smokers (n=18). Two functional magnetic resonance imaging (fMRI) scans were completed over a single study day, following overnight smoking abstinence (pre-smoking scan) and after cigarette reinstatement (post-smoking scan). During the pre-smoking scan positive correlations between BOLD activity and HAMD scores were observed in areas of the mesocorticolimbic dopaminergic system [inferior frontal gyrus, middle frontal gyrus (MFG), hippocampus (HC), anterior cingulate gyrus] and areas of the visuospatial attention circuit (medial occipital lobe, middle cingulate cortex, superior frontal gyrus, angular gyrus). During the post-smoking scan positive correlations were observed in areas of the brain implicated in drug expectancy (MFG), memory (HC), attentional motivation (posterior cingulate cortex), and visual processing and attention (precuneus). These preliminary findings demonstrate that smokers with higher depression severity attribute greater incentive salience to smoking-related cues and this is especially pronounced during periods of acute abstinence. Such enhanced salience of smoking cues, even after smoking a cigarette, may play a critical role both in the maintenance of smoking in depression and in greater levels of nicotine dependence seen in this patient population.</jats:p> |
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| author_facet | Kushnir, Vladyslav, Menon, Mahesh, Balducci, Xavier L., Selby, Peter, Busto, Usoa, Zawertailo, Laurie, Kushnir, Vladyslav, Menon, Mahesh, Balducci, Xavier L., Selby, Peter, Busto, Usoa, Zawertailo, Laurie |
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| description | <jats:title>Abstract</jats:title> <jats:p>The association between cigarette smoking and depression has been well documented; however, little research has been done to elucidate the neurobiological substrates of this highly prevalent comorbidity. We used multiple linear regression analysis to evaluate the relationship between depression severity as assessed by the Hamilton Depression Rating Scale (HAMD) and blood oxygen level-dependent (BOLD) responses to visual smoking cues in drug-free nicotine-dependent smokers (n=18). Two functional magnetic resonance imaging (fMRI) scans were completed over a single study day, following overnight smoking abstinence (pre-smoking scan) and after cigarette reinstatement (post-smoking scan). During the pre-smoking scan positive correlations between BOLD activity and HAMD scores were observed in areas of the mesocorticolimbic dopaminergic system [inferior frontal gyrus, middle frontal gyrus (MFG), hippocampus (HC), anterior cingulate gyrus] and areas of the visuospatial attention circuit (medial occipital lobe, middle cingulate cortex, superior frontal gyrus, angular gyrus). During the post-smoking scan positive correlations were observed in areas of the brain implicated in drug expectancy (MFG), memory (HC), attentional motivation (posterior cingulate cortex), and visual processing and attention (precuneus). These preliminary findings demonstrate that smokers with higher depression severity attribute greater incentive salience to smoking-related cues and this is especially pronounced during periods of acute abstinence. Such enhanced salience of smoking cues, even after smoking a cigarette, may play a critical role both in the maintenance of smoking in depression and in greater levels of nicotine dependence seen in this patient population.</jats:p> |
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| spelling | Kushnir, Vladyslav Menon, Mahesh Balducci, Xavier L. Selby, Peter Busto, Usoa Zawertailo, Laurie 1469-5111 1461-1457 Oxford University Press (OUP) Pharmacology (medical) Psychiatry and Mental health Pharmacology http://dx.doi.org/10.1017/s1461145710000696 <jats:title>Abstract</jats:title> <jats:p>The association between cigarette smoking and depression has been well documented; however, little research has been done to elucidate the neurobiological substrates of this highly prevalent comorbidity. We used multiple linear regression analysis to evaluate the relationship between depression severity as assessed by the Hamilton Depression Rating Scale (HAMD) and blood oxygen level-dependent (BOLD) responses to visual smoking cues in drug-free nicotine-dependent smokers (n=18). Two functional magnetic resonance imaging (fMRI) scans were completed over a single study day, following overnight smoking abstinence (pre-smoking scan) and after cigarette reinstatement (post-smoking scan). During the pre-smoking scan positive correlations between BOLD activity and HAMD scores were observed in areas of the mesocorticolimbic dopaminergic system [inferior frontal gyrus, middle frontal gyrus (MFG), hippocampus (HC), anterior cingulate gyrus] and areas of the visuospatial attention circuit (medial occipital lobe, middle cingulate cortex, superior frontal gyrus, angular gyrus). During the post-smoking scan positive correlations were observed in areas of the brain implicated in drug expectancy (MFG), memory (HC), attentional motivation (posterior cingulate cortex), and visual processing and attention (precuneus). These preliminary findings demonstrate that smokers with higher depression severity attribute greater incentive salience to smoking-related cues and this is especially pronounced during periods of acute abstinence. Such enhanced salience of smoking cues, even after smoking a cigarette, may play a critical role both in the maintenance of smoking in depression and in greater levels of nicotine dependence seen in this patient population.</jats:p> Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study International Journal of Neuropsychopharmacology |
| spellingShingle | Kushnir, Vladyslav, Menon, Mahesh, Balducci, Xavier L., Selby, Peter, Busto, Usoa, Zawertailo, Laurie, International Journal of Neuropsychopharmacology, Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study, Pharmacology (medical), Psychiatry and Mental health, Pharmacology |
| title | Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_full | Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_fullStr | Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_full_unstemmed | Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_short | Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| title_sort | enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fmri study |
| title_unstemmed | Enhanced smoking cue salience associated with depression severity in nicotine-dependent individuals: a preliminary fMRI study |
| topic | Pharmacology (medical), Psychiatry and Mental health, Pharmacology |
| url | http://dx.doi.org/10.1017/s1461145710000696 |