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Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study
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| Zeitschriftentitel: | Public Health Nutrition |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| In: | Public Health Nutrition, 18, 2015, 7, S. 1324-1331 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
|
| Schlagwörter: |
| author_facet |
Moore, Amy Hochner, Hagit Sitlani, Colleen M Williams, Michelle A Hoofnagle, Andrew N de Boer, Ian H Kestenbaum, Bryan Siscovick, David S Friedlander, Yechiel Enquobahrie, Daniel A Moore, Amy Hochner, Hagit Sitlani, Colleen M Williams, Michelle A Hoofnagle, Andrew N de Boer, Ian H Kestenbaum, Bryan Siscovick, David S Friedlander, Yechiel Enquobahrie, Daniel A |
|---|---|
| author |
Moore, Amy Hochner, Hagit Sitlani, Colleen M Williams, Michelle A Hoofnagle, Andrew N de Boer, Ian H Kestenbaum, Bryan Siscovick, David S Friedlander, Yechiel Enquobahrie, Daniel A |
| spellingShingle |
Moore, Amy Hochner, Hagit Sitlani, Colleen M Williams, Michelle A Hoofnagle, Andrew N de Boer, Ian H Kestenbaum, Bryan Siscovick, David S Friedlander, Yechiel Enquobahrie, Daniel A Public Health Nutrition Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) |
| author_sort |
moore, amy |
| spelling |
Moore, Amy Hochner, Hagit Sitlani, Colleen M Williams, Michelle A Hoofnagle, Andrew N de Boer, Ian H Kestenbaum, Bryan Siscovick, David S Friedlander, Yechiel Enquobahrie, Daniel A 1368-9800 1475-2727 Cambridge University Press (CUP) Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s1368980014001475 <jats:title>Abstract</jats:title><jats:sec id="S1368980014001475_abs1" sec-type="general"><jats:title>Objective</jats:title><jats:p>To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs2" sec-type="general"><jats:title>Design</jats:title><jats:p>Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC–tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs3" sec-type="general"><jats:title>Setting</jats:title><jats:p>Individuals born in Jerusalem during 1974–1976.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs4" sec-type="subjects"><jats:title>Subjects</jats:title><jats:p>Participants of the Jerusalem Perinatal Study (<jats:italic>n</jats:italic> 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs5" sec-type="results"><jats:title>Results</jats:title><jats:p>Mean total 25(OH)D concentration among participants was 21·7 (<jats:sc>sd</jats:sc> 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, <jats:italic>β</jats:italic>=−0·011, <jats:italic>P</jats:italic>=0·004) after adjustment for BMI. However, these associations were not present among females (<jats:italic>P</jats:italic> for sex interaction=0·005).</jats:p></jats:sec><jats:sec id="S1368980014001475_abs6" sec-type="conclusions"><jats:title>Conclusions</jats:title><jats:p>We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.</jats:p></jats:sec> Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study Public Health Nutrition |
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10.1017/s1368980014001475 |
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Cambridge University Press (CUP), 2015 |
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Cambridge University Press (CUP), 2015 |
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Public Health Nutrition |
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| title |
Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_unstemmed |
Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_full |
Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_fullStr |
Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_full_unstemmed |
Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_short |
Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_sort |
plasma vitamin d is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the jerusalem perinatal study |
| topic |
Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) |
| url |
http://dx.doi.org/10.1017/s1368980014001475 |
| publishDate |
2015 |
| physical |
1324-1331 |
| description |
<jats:title>Abstract</jats:title><jats:sec id="S1368980014001475_abs1" sec-type="general"><jats:title>Objective</jats:title><jats:p>To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs2" sec-type="general"><jats:title>Design</jats:title><jats:p>Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC–tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs3" sec-type="general"><jats:title>Setting</jats:title><jats:p>Individuals born in Jerusalem during 1974–1976.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs4" sec-type="subjects"><jats:title>Subjects</jats:title><jats:p>Participants of the Jerusalem Perinatal Study (<jats:italic>n</jats:italic> 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs5" sec-type="results"><jats:title>Results</jats:title><jats:p>Mean total 25(OH)D concentration among participants was 21·7 (<jats:sc>sd</jats:sc> 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, <jats:italic>β</jats:italic>=−0·011, <jats:italic>P</jats:italic>=0·004) after adjustment for BMI. However, these associations were not present among females (<jats:italic>P</jats:italic> for sex interaction=0·005).</jats:p></jats:sec><jats:sec id="S1368980014001475_abs6" sec-type="conclusions"><jats:title>Conclusions</jats:title><jats:p>We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.</jats:p></jats:sec> |
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| author | Moore, Amy, Hochner, Hagit, Sitlani, Colleen M, Williams, Michelle A, Hoofnagle, Andrew N, de Boer, Ian H, Kestenbaum, Bryan, Siscovick, David S, Friedlander, Yechiel, Enquobahrie, Daniel A |
| author_facet | Moore, Amy, Hochner, Hagit, Sitlani, Colleen M, Williams, Michelle A, Hoofnagle, Andrew N, de Boer, Ian H, Kestenbaum, Bryan, Siscovick, David S, Friedlander, Yechiel, Enquobahrie, Daniel A, Moore, Amy, Hochner, Hagit, Sitlani, Colleen M, Williams, Michelle A, Hoofnagle, Andrew N, de Boer, Ian H, Kestenbaum, Bryan, Siscovick, David S, Friedlander, Yechiel, Enquobahrie, Daniel A |
| author_sort | moore, amy |
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| description | <jats:title>Abstract</jats:title><jats:sec id="S1368980014001475_abs1" sec-type="general"><jats:title>Objective</jats:title><jats:p>To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs2" sec-type="general"><jats:title>Design</jats:title><jats:p>Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC–tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs3" sec-type="general"><jats:title>Setting</jats:title><jats:p>Individuals born in Jerusalem during 1974–1976.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs4" sec-type="subjects"><jats:title>Subjects</jats:title><jats:p>Participants of the Jerusalem Perinatal Study (<jats:italic>n</jats:italic> 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs5" sec-type="results"><jats:title>Results</jats:title><jats:p>Mean total 25(OH)D concentration among participants was 21·7 (<jats:sc>sd</jats:sc> 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, <jats:italic>β</jats:italic>=−0·011, <jats:italic>P</jats:italic>=0·004) after adjustment for BMI. However, these associations were not present among females (<jats:italic>P</jats:italic> for sex interaction=0·005).</jats:p></jats:sec><jats:sec id="S1368980014001475_abs6" sec-type="conclusions"><jats:title>Conclusions</jats:title><jats:p>We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.</jats:p></jats:sec> |
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| spelling | Moore, Amy Hochner, Hagit Sitlani, Colleen M Williams, Michelle A Hoofnagle, Andrew N de Boer, Ian H Kestenbaum, Bryan Siscovick, David S Friedlander, Yechiel Enquobahrie, Daniel A 1368-9800 1475-2727 Cambridge University Press (CUP) Public Health, Environmental and Occupational Health Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s1368980014001475 <jats:title>Abstract</jats:title><jats:sec id="S1368980014001475_abs1" sec-type="general"><jats:title>Objective</jats:title><jats:p>To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs2" sec-type="general"><jats:title>Design</jats:title><jats:p>Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC–tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs3" sec-type="general"><jats:title>Setting</jats:title><jats:p>Individuals born in Jerusalem during 1974–1976.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs4" sec-type="subjects"><jats:title>Subjects</jats:title><jats:p>Participants of the Jerusalem Perinatal Study (<jats:italic>n</jats:italic> 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity.</jats:p></jats:sec><jats:sec id="S1368980014001475_abs5" sec-type="results"><jats:title>Results</jats:title><jats:p>Mean total 25(OH)D concentration among participants was 21·7 (<jats:sc>sd</jats:sc> 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, <jats:italic>β</jats:italic>=−0·011, <jats:italic>P</jats:italic>=0·004) after adjustment for BMI. However, these associations were not present among females (<jats:italic>P</jats:italic> for sex interaction=0·005).</jats:p></jats:sec><jats:sec id="S1368980014001475_abs6" sec-type="conclusions"><jats:title>Conclusions</jats:title><jats:p>We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.</jats:p></jats:sec> Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study Public Health Nutrition |
| spellingShingle | Moore, Amy, Hochner, Hagit, Sitlani, Colleen M, Williams, Michelle A, Hoofnagle, Andrew N, de Boer, Ian H, Kestenbaum, Bryan, Siscovick, David S, Friedlander, Yechiel, Enquobahrie, Daniel A, Public Health Nutrition, Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study, Public Health, Environmental and Occupational Health, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_full | Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_fullStr | Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_full_unstemmed | Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_short | Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| title_sort | plasma vitamin d is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the jerusalem perinatal study |
| title_unstemmed | Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study |
| topic | Public Health, Environmental and Occupational Health, Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1017/s1368980014001475 |