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Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli
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| Zeitschriftentitel: | Epidemiology and Infection |
|---|---|
| Personen und Körperschaften: | , |
| In: | Epidemiology and Infection, 108, 1992, 2, S. 315-322 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
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| Schlagwörter: |
| author_facet |
Brüssow, H. Sidoti, J. Brüssow, H. Sidoti, J. |
|---|---|
| author |
Brüssow, H. Sidoti, J. |
| spellingShingle |
Brüssow, H. Sidoti, J. Epidemiology and Infection Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli Infectious Diseases Epidemiology |
| author_sort |
brüssow, h. |
| spelling |
Brüssow, H. Sidoti, J. 0950-2688 1469-4409 Cambridge University Press (CUP) Infectious Diseases Epidemiology http://dx.doi.org/10.1017/s0950268800049785 <jats:title>SUMMARY</jats:title><jats:p>Fifteen and five of 20 volunteers challenged with the enterotoxigenic<jats:italic>Escherichia coli</jats:italic>strain O 78·H11 showed a fourfold titre increase of serum ELISA antibody to the homologous O 78 and the heterologous O 8 lipopolysaccharide antigen, respectively. Sixty-three of 191 sera from 1- to 48-month-old German children showed serum antibody reactive with O 78 antigen, all but two of these O 78-positive sera also showed reactivity with at least one further O antigen. Only 14 of the O 78 reactive sera also showed antibody to heat-labile enterotoxin. In addition, soluble O 8 antigen could inhibit the binding of serum antibody to absorbed O 78 in 68% of the German children. Antibody reactive with O 78 antigen is thus not a reliable serological marker for enterotoxigenic<jats:italic>E. coli</jats:italic>infection in German children.</jats:p> Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenic<i>Escherichia coli</i> Epidemiology and Infection |
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Cambridge University Press (CUP), 1992 |
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Cambridge University Press (CUP), 1992 |
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0950-2688 1469-4409 |
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Epidemiology and Infection |
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| title |
Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_unstemmed |
Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_full |
Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_fullStr |
Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_full_unstemmed |
Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_short |
Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_sort |
reactivity of human serum antibody with lipopolysaccharide o 78 antigen from enterotoxigenic<i>escherichia coli</i> |
| topic |
Infectious Diseases Epidemiology |
| url |
http://dx.doi.org/10.1017/s0950268800049785 |
| publishDate |
1992 |
| physical |
315-322 |
| description |
<jats:title>SUMMARY</jats:title><jats:p>Fifteen and five of 20 volunteers challenged with the enterotoxigenic<jats:italic>Escherichia coli</jats:italic>strain O 78·H11 showed a fourfold titre increase of serum ELISA antibody to the homologous O 78 and the heterologous O 8 lipopolysaccharide antigen, respectively. Sixty-three of 191 sera from 1- to 48-month-old German children showed serum antibody reactive with O 78 antigen, all but two of these O 78-positive sera also showed reactivity with at least one further O antigen. Only 14 of the O 78 reactive sera also showed antibody to heat-labile enterotoxin. In addition, soluble O 8 antigen could inhibit the binding of serum antibody to absorbed O 78 in 68% of the German children. Antibody reactive with O 78 antigen is thus not a reliable serological marker for enterotoxigenic<jats:italic>E. coli</jats:italic>infection in German children.</jats:p> |
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| author | Brüssow, H., Sidoti, J. |
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| author_sort | brüssow, h. |
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| description | <jats:title>SUMMARY</jats:title><jats:p>Fifteen and five of 20 volunteers challenged with the enterotoxigenic<jats:italic>Escherichia coli</jats:italic>strain O 78·H11 showed a fourfold titre increase of serum ELISA antibody to the homologous O 78 and the heterologous O 8 lipopolysaccharide antigen, respectively. Sixty-three of 191 sera from 1- to 48-month-old German children showed serum antibody reactive with O 78 antigen, all but two of these O 78-positive sera also showed reactivity with at least one further O antigen. Only 14 of the O 78 reactive sera also showed antibody to heat-labile enterotoxin. In addition, soluble O 8 antigen could inhibit the binding of serum antibody to absorbed O 78 in 68% of the German children. Antibody reactive with O 78 antigen is thus not a reliable serological marker for enterotoxigenic<jats:italic>E. coli</jats:italic>infection in German children.</jats:p> |
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| imprint | Cambridge University Press (CUP), 1992 |
| imprint_str_mv | Cambridge University Press (CUP), 1992 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 315-322 |
| publishDate | 1992 |
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| series | Epidemiology and Infection |
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| spelling | Brüssow, H. Sidoti, J. 0950-2688 1469-4409 Cambridge University Press (CUP) Infectious Diseases Epidemiology http://dx.doi.org/10.1017/s0950268800049785 <jats:title>SUMMARY</jats:title><jats:p>Fifteen and five of 20 volunteers challenged with the enterotoxigenic<jats:italic>Escherichia coli</jats:italic>strain O 78·H11 showed a fourfold titre increase of serum ELISA antibody to the homologous O 78 and the heterologous O 8 lipopolysaccharide antigen, respectively. Sixty-three of 191 sera from 1- to 48-month-old German children showed serum antibody reactive with O 78 antigen, all but two of these O 78-positive sera also showed reactivity with at least one further O antigen. Only 14 of the O 78 reactive sera also showed antibody to heat-labile enterotoxin. In addition, soluble O 8 antigen could inhibit the binding of serum antibody to absorbed O 78 in 68% of the German children. Antibody reactive with O 78 antigen is thus not a reliable serological marker for enterotoxigenic<jats:italic>E. coli</jats:italic>infection in German children.</jats:p> Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenic<i>Escherichia coli</i> Epidemiology and Infection |
| spellingShingle | Brüssow, H., Sidoti, J., Epidemiology and Infection, Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli, Infectious Diseases, Epidemiology |
| title | Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_full | Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_fullStr | Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_full_unstemmed | Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_short | Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| title_sort | reactivity of human serum antibody with lipopolysaccharide o 78 antigen from enterotoxigenic<i>escherichia coli</i> |
| title_unstemmed | Reactivity of human serum antibody with lipopolysaccharide O 78 antigen from enterotoxigenicEscherichia coli |
| topic | Infectious Diseases, Epidemiology |
| url | http://dx.doi.org/10.1017/s0950268800049785 |