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Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway?
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| Zeitschriftentitel: | Proceedings of the Nutrition Society |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Proceedings of the Nutrition Society, 74, 2015, 3, S. 282-291 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
|
| Schlagwörter: |
| author_facet |
Malcomson, Fiona C. Willis, Naomi D. Mathers, John C. Malcomson, Fiona C. Willis, Naomi D. Mathers, John C. |
|---|---|
| author |
Malcomson, Fiona C. Willis, Naomi D. Mathers, John C. |
| spellingShingle |
Malcomson, Fiona C. Willis, Naomi D. Mathers, John C. Proceedings of the Nutrition Society Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? Nutrition and Dietetics Medicine (miscellaneous) |
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malcomson, fiona c. |
| spelling |
Malcomson, Fiona C. Willis, Naomi D. Mathers, John C. 0029-6651 1475-2719 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s002966511500004x <jats:p>Epidemiological and experimental evidence suggests that non-digestible carbohydrates (NDC) including resistant starch are protective against colorectal cancer. These anti-neoplastic effects are presumed to result from the production of the SCFA, butyrate, by colonic fermentation, which binds to the G-protein-coupled receptor GPR43 to regulate inflammation and other cancer-related processes. The WNT pathway is central to the maintenance of homeostasis within the large bowel through regulation of processes such as cell proliferation and migration and is frequently aberrantly hyperactivated in colorectal cancers. Abnormal WNT signalling can lead to irregular crypt cell proliferation that favours a hyperproliferative state. Butyrate has been shown to modulate the WNT pathway positively, affecting functional outcomes such as apoptosis and proliferation. Butyrate's ability to regulate gene expression results from epigenetic mechanisms, including its role as a histone deacetylase inhibitor and through modulating DNA methylation and the expression of microRNA. We conclude that genetic and epigenetic modulation of the WNT signalling pathway may be an important mechanism through which butyrate from fermentation of resistant starch and other NDC exert their chemoprotective effects.</jats:p> Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? Proceedings of the Nutrition Society |
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| title |
Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
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Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
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Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
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Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
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Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
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Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
| title_sort |
is resistant starch protective against colorectal cancer via modulation of the wnt signalling pathway? |
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Nutrition and Dietetics Medicine (miscellaneous) |
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http://dx.doi.org/10.1017/s002966511500004x |
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2015 |
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282-291 |
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<jats:p>Epidemiological and experimental evidence suggests that non-digestible carbohydrates (NDC) including resistant starch are protective against colorectal cancer. These anti-neoplastic effects are presumed to result from the production of the SCFA, butyrate, by colonic fermentation, which binds to the G-protein-coupled receptor GPR43 to regulate inflammation and other cancer-related processes. The WNT pathway is central to the maintenance of homeostasis within the large bowel through regulation of processes such as cell proliferation and migration and is frequently aberrantly hyperactivated in colorectal cancers. Abnormal WNT signalling can lead to irregular crypt cell proliferation that favours a hyperproliferative state. Butyrate has been shown to modulate the WNT pathway positively, affecting functional outcomes such as apoptosis and proliferation. Butyrate's ability to regulate gene expression results from epigenetic mechanisms, including its role as a histone deacetylase inhibitor and through modulating DNA methylation and the expression of microRNA. We conclude that genetic and epigenetic modulation of the WNT signalling pathway may be an important mechanism through which butyrate from fermentation of resistant starch and other NDC exert their chemoprotective effects.</jats:p> |
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| author | Malcomson, Fiona C., Willis, Naomi D., Mathers, John C. |
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| description | <jats:p>Epidemiological and experimental evidence suggests that non-digestible carbohydrates (NDC) including resistant starch are protective against colorectal cancer. These anti-neoplastic effects are presumed to result from the production of the SCFA, butyrate, by colonic fermentation, which binds to the G-protein-coupled receptor GPR43 to regulate inflammation and other cancer-related processes. The WNT pathway is central to the maintenance of homeostasis within the large bowel through regulation of processes such as cell proliferation and migration and is frequently aberrantly hyperactivated in colorectal cancers. Abnormal WNT signalling can lead to irregular crypt cell proliferation that favours a hyperproliferative state. Butyrate has been shown to modulate the WNT pathway positively, affecting functional outcomes such as apoptosis and proliferation. Butyrate's ability to regulate gene expression results from epigenetic mechanisms, including its role as a histone deacetylase inhibitor and through modulating DNA methylation and the expression of microRNA. We conclude that genetic and epigenetic modulation of the WNT signalling pathway may be an important mechanism through which butyrate from fermentation of resistant starch and other NDC exert their chemoprotective effects.</jats:p> |
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| spelling | Malcomson, Fiona C. Willis, Naomi D. Mathers, John C. 0029-6651 1475-2719 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s002966511500004x <jats:p>Epidemiological and experimental evidence suggests that non-digestible carbohydrates (NDC) including resistant starch are protective against colorectal cancer. These anti-neoplastic effects are presumed to result from the production of the SCFA, butyrate, by colonic fermentation, which binds to the G-protein-coupled receptor GPR43 to regulate inflammation and other cancer-related processes. The WNT pathway is central to the maintenance of homeostasis within the large bowel through regulation of processes such as cell proliferation and migration and is frequently aberrantly hyperactivated in colorectal cancers. Abnormal WNT signalling can lead to irregular crypt cell proliferation that favours a hyperproliferative state. Butyrate has been shown to modulate the WNT pathway positively, affecting functional outcomes such as apoptosis and proliferation. Butyrate's ability to regulate gene expression results from epigenetic mechanisms, including its role as a histone deacetylase inhibitor and through modulating DNA methylation and the expression of microRNA. We conclude that genetic and epigenetic modulation of the WNT signalling pathway may be an important mechanism through which butyrate from fermentation of resistant starch and other NDC exert their chemoprotective effects.</jats:p> Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? Proceedings of the Nutrition Society |
| spellingShingle | Malcomson, Fiona C., Willis, Naomi D., Mathers, John C., Proceedings of the Nutrition Society, Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway?, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
| title_full | Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
| title_fullStr | Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
| title_full_unstemmed | Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
| title_short | Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
| title_sort | is resistant starch protective against colorectal cancer via modulation of the wnt signalling pathway? |
| title_unstemmed | Is resistant starch protective against colorectal cancer via modulation of the WNT signalling pathway? |
| topic | Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1017/s002966511500004x |