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Allosuppressors in yeast
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| Zeitschriftentitel: | Genetical Research |
|---|---|
| Personen und Körperschaften: | |
| In: | Genetical Research, 30, 1977, 2, S. 187-205 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Hindawi Limited
|
| Schlagwörter: |
| author_facet |
Cox, B. S. Cox, B. S. |
|---|---|
| author |
Cox, B. S. |
| spellingShingle |
Cox, B. S. Genetical Research Allosuppressors in yeast Genetics General Medicine |
| author_sort |
cox, b. s. |
| spelling |
Cox, B. S. 0016-6723 1469-5073 Hindawi Limited Genetics General Medicine http://dx.doi.org/10.1017/s0016672300017584 <jats:title>SUMMARY</jats:title><jats:p>Five loci have been identified in<jats:italic>Saccharomyces cerevisiae</jats:italic>whose function reduces suppressor activity in strains carrying ochre super-suppressor mutations. Recessive mutations which allow an increased level of suppression occur at these loci. In such mutants, termed allosuppressors, the serine-inserting suppressor<jats:italic>SUPQ5</jats:italic>suppresses ochre mutations in a [<jats:italic>psi</jats:italic><jats:sup>−</jats:sup>] background and Class I tyrosine-inserting suppressors are lethal or have a reduced viability. Mutations at two allosuppressor loci,<jats:italic>sal</jats:italic>3 and<jats:italic>sal</jats:italic>4, have a lethal interaction with one another and with the extrachromosomal determinant [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>]. This interaction is expressed in the absence of any suppressor mutation. All the mutant alleles of one allosuppressor locus<jats:italic>sal</jats:italic>3 are cold sensitive. One allosuppressor mutation,<jats:italic>sal</jats:italic>4.2, is temperature-sensitive for growth, as well as for other aspects of its phenotypic expression; namely the expression of<jats:italic>SUPQ5</jats:italic>and the lethal interactions with Class I super-suppressors, with [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] and with<jats:italic>sal</jats:italic>3. At low temperature (24 °C),<jats:italic>sal</jats:italic>3-<jats:italic>sal</jats:italic>4.2 double mutants weakly suppress the ochre mutation<jats:italic>ade</jats:italic>2.1, but do not suppress<jats:italic>his</jats:italic>5.2 or<jats:italic>lys</jats:italic>1.1. It is argued that the site of function of the products of these loci is ribosomal and that they are involved in chain termination at UAA codons. It is inferred that the [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] factor or its product affects protein synthesis by interaction with the ribosome.</jats:p> Allosuppressors in yeast Genetical Research |
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10.1017/s0016672300017584 |
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Online Free |
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Biologie |
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Hindawi Limited, 1977 |
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Hindawi Limited, 1977 |
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0016-6723 1469-5073 |
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0016-6723 1469-5073 |
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English |
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Hindawi Limited (CrossRef) |
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1977 |
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Hindawi Limited |
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Genetical Research |
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49 |
| title |
Allosuppressors in yeast |
| title_unstemmed |
Allosuppressors in yeast |
| title_full |
Allosuppressors in yeast |
| title_fullStr |
Allosuppressors in yeast |
| title_full_unstemmed |
Allosuppressors in yeast |
| title_short |
Allosuppressors in yeast |
| title_sort |
allosuppressors in yeast |
| topic |
Genetics General Medicine |
| url |
http://dx.doi.org/10.1017/s0016672300017584 |
| publishDate |
1977 |
| physical |
187-205 |
| description |
<jats:title>SUMMARY</jats:title><jats:p>Five loci have been identified in<jats:italic>Saccharomyces cerevisiae</jats:italic>whose function reduces suppressor activity in strains carrying ochre super-suppressor mutations. Recessive mutations which allow an increased level of suppression occur at these loci. In such mutants, termed allosuppressors, the serine-inserting suppressor<jats:italic>SUPQ5</jats:italic>suppresses ochre mutations in a [<jats:italic>psi</jats:italic><jats:sup>−</jats:sup>] background and Class I tyrosine-inserting suppressors are lethal or have a reduced viability. Mutations at two allosuppressor loci,<jats:italic>sal</jats:italic>3 and<jats:italic>sal</jats:italic>4, have a lethal interaction with one another and with the extrachromosomal determinant [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>]. This interaction is expressed in the absence of any suppressor mutation. All the mutant alleles of one allosuppressor locus<jats:italic>sal</jats:italic>3 are cold sensitive. One allosuppressor mutation,<jats:italic>sal</jats:italic>4.2, is temperature-sensitive for growth, as well as for other aspects of its phenotypic expression; namely the expression of<jats:italic>SUPQ5</jats:italic>and the lethal interactions with Class I super-suppressors, with [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] and with<jats:italic>sal</jats:italic>3. At low temperature (24 °C),<jats:italic>sal</jats:italic>3-<jats:italic>sal</jats:italic>4.2 double mutants weakly suppress the ochre mutation<jats:italic>ade</jats:italic>2.1, but do not suppress<jats:italic>his</jats:italic>5.2 or<jats:italic>lys</jats:italic>1.1. It is argued that the site of function of the products of these loci is ribosomal and that they are involved in chain termination at UAA codons. It is inferred that the [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] factor or its product affects protein synthesis by interaction with the ribosome.</jats:p> |
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| author | Cox, B. S. |
| author_facet | Cox, B. S., Cox, B. S. |
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| description | <jats:title>SUMMARY</jats:title><jats:p>Five loci have been identified in<jats:italic>Saccharomyces cerevisiae</jats:italic>whose function reduces suppressor activity in strains carrying ochre super-suppressor mutations. Recessive mutations which allow an increased level of suppression occur at these loci. In such mutants, termed allosuppressors, the serine-inserting suppressor<jats:italic>SUPQ5</jats:italic>suppresses ochre mutations in a [<jats:italic>psi</jats:italic><jats:sup>−</jats:sup>] background and Class I tyrosine-inserting suppressors are lethal or have a reduced viability. Mutations at two allosuppressor loci,<jats:italic>sal</jats:italic>3 and<jats:italic>sal</jats:italic>4, have a lethal interaction with one another and with the extrachromosomal determinant [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>]. This interaction is expressed in the absence of any suppressor mutation. All the mutant alleles of one allosuppressor locus<jats:italic>sal</jats:italic>3 are cold sensitive. One allosuppressor mutation,<jats:italic>sal</jats:italic>4.2, is temperature-sensitive for growth, as well as for other aspects of its phenotypic expression; namely the expression of<jats:italic>SUPQ5</jats:italic>and the lethal interactions with Class I super-suppressors, with [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] and with<jats:italic>sal</jats:italic>3. At low temperature (24 °C),<jats:italic>sal</jats:italic>3-<jats:italic>sal</jats:italic>4.2 double mutants weakly suppress the ochre mutation<jats:italic>ade</jats:italic>2.1, but do not suppress<jats:italic>his</jats:italic>5.2 or<jats:italic>lys</jats:italic>1.1. It is argued that the site of function of the products of these loci is ribosomal and that they are involved in chain termination at UAA codons. It is inferred that the [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] factor or its product affects protein synthesis by interaction with the ribosome.</jats:p> |
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| imprint | Hindawi Limited, 1977 |
| imprint_str_mv | Hindawi Limited, 1977 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14 |
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| language | English |
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| physical | 187-205 |
| publishDate | 1977 |
| publishDateSort | 1977 |
| publisher | Hindawi Limited |
| record_format | ai |
| recordtype | ai |
| series | Genetical Research |
| source_id | 49 |
| spelling | Cox, B. S. 0016-6723 1469-5073 Hindawi Limited Genetics General Medicine http://dx.doi.org/10.1017/s0016672300017584 <jats:title>SUMMARY</jats:title><jats:p>Five loci have been identified in<jats:italic>Saccharomyces cerevisiae</jats:italic>whose function reduces suppressor activity in strains carrying ochre super-suppressor mutations. Recessive mutations which allow an increased level of suppression occur at these loci. In such mutants, termed allosuppressors, the serine-inserting suppressor<jats:italic>SUPQ5</jats:italic>suppresses ochre mutations in a [<jats:italic>psi</jats:italic><jats:sup>−</jats:sup>] background and Class I tyrosine-inserting suppressors are lethal or have a reduced viability. Mutations at two allosuppressor loci,<jats:italic>sal</jats:italic>3 and<jats:italic>sal</jats:italic>4, have a lethal interaction with one another and with the extrachromosomal determinant [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>]. This interaction is expressed in the absence of any suppressor mutation. All the mutant alleles of one allosuppressor locus<jats:italic>sal</jats:italic>3 are cold sensitive. One allosuppressor mutation,<jats:italic>sal</jats:italic>4.2, is temperature-sensitive for growth, as well as for other aspects of its phenotypic expression; namely the expression of<jats:italic>SUPQ5</jats:italic>and the lethal interactions with Class I super-suppressors, with [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] and with<jats:italic>sal</jats:italic>3. At low temperature (24 °C),<jats:italic>sal</jats:italic>3-<jats:italic>sal</jats:italic>4.2 double mutants weakly suppress the ochre mutation<jats:italic>ade</jats:italic>2.1, but do not suppress<jats:italic>his</jats:italic>5.2 or<jats:italic>lys</jats:italic>1.1. It is argued that the site of function of the products of these loci is ribosomal and that they are involved in chain termination at UAA codons. It is inferred that the [<jats:italic>psi</jats:italic><jats:sup>+</jats:sup>] factor or its product affects protein synthesis by interaction with the ribosome.</jats:p> Allosuppressors in yeast Genetical Research |
| spellingShingle | Cox, B. S., Genetical Research, Allosuppressors in yeast, Genetics, General Medicine |
| title | Allosuppressors in yeast |
| title_full | Allosuppressors in yeast |
| title_fullStr | Allosuppressors in yeast |
| title_full_unstemmed | Allosuppressors in yeast |
| title_short | Allosuppressors in yeast |
| title_sort | allosuppressors in yeast |
| title_unstemmed | Allosuppressors in yeast |
| topic | Genetics, General Medicine |
| url | http://dx.doi.org/10.1017/s0016672300017584 |