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Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition
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| Zeitschriftentitel: | British Journal of Nutrition |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | British Journal of Nutrition, 120, 2018, 1, S. 23-32 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
|
| Schlagwörter: |
| author_facet |
Fisk, Helena L. Irvine, Michael Miles, Elizabeth A. Lietz, Georg Mathers, John C. Packard, Chris J. Armah, Christopher K. Kofler, Bettina M. Curtis, Peter J. Minihane, Anne M. Calder, Philip C. Fisk, Helena L. Irvine, Michael Miles, Elizabeth A. Lietz, Georg Mathers, John C. Packard, Chris J. Armah, Christopher K. Kofler, Bettina M. Curtis, Peter J. Minihane, Anne M. Calder, Philip C. |
|---|---|
| author |
Fisk, Helena L. Irvine, Michael Miles, Elizabeth A. Lietz, Georg Mathers, John C. Packard, Chris J. Armah, Christopher K. Kofler, Bettina M. Curtis, Peter J. Minihane, Anne M. Calder, Philip C. |
| spellingShingle |
Fisk, Helena L. Irvine, Michael Miles, Elizabeth A. Lietz, Georg Mathers, John C. Packard, Chris J. Armah, Christopher K. Kofler, Bettina M. Curtis, Peter J. Minihane, Anne M. Calder, Philip C. British Journal of Nutrition Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition Nutrition and Dietetics Medicine (miscellaneous) |
| author_sort |
fisk, helena l. |
| spelling |
Fisk, Helena L. Irvine, Michael Miles, Elizabeth A. Lietz, Georg Mathers, John C. Packard, Chris J. Armah, Christopher K. Kofler, Bettina M. Curtis, Peter J. Minihane, Anne M. Calder, Philip C. 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s000711451800106x <jats:title>Abstract</jats:title><jats:p><jats:italic>n</jats:italic>-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to<jats:italic>APOE</jats:italic>genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with EPA in PC, CE and TAG, DPA in TAG, and DHA in all fractions (<jats:italic>P</jats:italic>≤0·008). There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (<jats:italic>P</jats:italic>≤0·034). DPA was higher in TAG in males than females (<jats:italic>P</jats:italic><0·001). There was a positive association between BMI and DPA and DHA in TAG (<jats:italic>P</jats:italic><0·006 and 0·02, respectively).<jats:italic>APOE</jats:italic>genotype×sex interactions were observed: the<jats:italic>APOE</jats:italic>4 allele associated with higher EPA in males (<jats:italic>P</jats:italic>=0·002), and there was also evidence for higher DPA and DHA (<jats:italic>P</jats:italic>≤0·032). In conclusion, EPA, DPA and DHA in plasma lipids are associated with oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype. Such insights may be used to better understand the link between plasma fatty acid profiles and dietary exposure and may influence intake recommendations across population subgroups.</jats:p> Association of oily fish intake, sex, age, BMI and<i>APOE</i>genotype with plasma long-chain<i>n</i>-3 fatty acid composition British Journal of Nutrition |
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| title |
Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_unstemmed |
Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_full |
Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_fullStr |
Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_full_unstemmed |
Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_short |
Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_sort |
association of oily fish intake, sex, age, bmi and<i>apoe</i>genotype with plasma long-chain<i>n</i>-3 fatty acid composition |
| topic |
Nutrition and Dietetics Medicine (miscellaneous) |
| url |
http://dx.doi.org/10.1017/s000711451800106x |
| publishDate |
2018 |
| physical |
23-32 |
| description |
<jats:title>Abstract</jats:title><jats:p><jats:italic>n</jats:italic>-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to<jats:italic>APOE</jats:italic>genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with EPA in PC, CE and TAG, DPA in TAG, and DHA in all fractions (<jats:italic>P</jats:italic>≤0·008). There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (<jats:italic>P</jats:italic>≤0·034). DPA was higher in TAG in males than females (<jats:italic>P</jats:italic><0·001). There was a positive association between BMI and DPA and DHA in TAG (<jats:italic>P</jats:italic><0·006 and 0·02, respectively).<jats:italic>APOE</jats:italic>genotype×sex interactions were observed: the<jats:italic>APOE</jats:italic>4 allele associated with higher EPA in males (<jats:italic>P</jats:italic>=0·002), and there was also evidence for higher DPA and DHA (<jats:italic>P</jats:italic>≤0·032). In conclusion, EPA, DPA and DHA in plasma lipids are associated with oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype. Such insights may be used to better understand the link between plasma fatty acid profiles and dietary exposure and may influence intake recommendations across population subgroups.</jats:p> |
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| author | Fisk, Helena L., Irvine, Michael, Miles, Elizabeth A., Lietz, Georg, Mathers, John C., Packard, Chris J., Armah, Christopher K., Kofler, Bettina M., Curtis, Peter J., Minihane, Anne M., Calder, Philip C. |
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| description | <jats:title>Abstract</jats:title><jats:p><jats:italic>n</jats:italic>-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to<jats:italic>APOE</jats:italic>genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with EPA in PC, CE and TAG, DPA in TAG, and DHA in all fractions (<jats:italic>P</jats:italic>≤0·008). There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (<jats:italic>P</jats:italic>≤0·034). DPA was higher in TAG in males than females (<jats:italic>P</jats:italic><0·001). There was a positive association between BMI and DPA and DHA in TAG (<jats:italic>P</jats:italic><0·006 and 0·02, respectively).<jats:italic>APOE</jats:italic>genotype×sex interactions were observed: the<jats:italic>APOE</jats:italic>4 allele associated with higher EPA in males (<jats:italic>P</jats:italic>=0·002), and there was also evidence for higher DPA and DHA (<jats:italic>P</jats:italic>≤0·032). In conclusion, EPA, DPA and DHA in plasma lipids are associated with oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype. Such insights may be used to better understand the link between plasma fatty acid profiles and dietary exposure and may influence intake recommendations across population subgroups.</jats:p> |
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| spelling | Fisk, Helena L. Irvine, Michael Miles, Elizabeth A. Lietz, Georg Mathers, John C. Packard, Chris J. Armah, Christopher K. Kofler, Bettina M. Curtis, Peter J. Minihane, Anne M. Calder, Philip C. 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s000711451800106x <jats:title>Abstract</jats:title><jats:p><jats:italic>n</jats:italic>-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to<jats:italic>APOE</jats:italic>genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with EPA in PC, CE and TAG, DPA in TAG, and DHA in all fractions (<jats:italic>P</jats:italic>≤0·008). There was a positive association between age and EPA in PC, CE and TAG, DPA in NEFA and CE, and DHA in PC and CE (<jats:italic>P</jats:italic>≤0·034). DPA was higher in TAG in males than females (<jats:italic>P</jats:italic><0·001). There was a positive association between BMI and DPA and DHA in TAG (<jats:italic>P</jats:italic><0·006 and 0·02, respectively).<jats:italic>APOE</jats:italic>genotype×sex interactions were observed: the<jats:italic>APOE</jats:italic>4 allele associated with higher EPA in males (<jats:italic>P</jats:italic>=0·002), and there was also evidence for higher DPA and DHA (<jats:italic>P</jats:italic>≤0·032). In conclusion, EPA, DPA and DHA in plasma lipids are associated with oily fish intake, sex, age, BMI and<jats:italic>APOE</jats:italic>genotype. Such insights may be used to better understand the link between plasma fatty acid profiles and dietary exposure and may influence intake recommendations across population subgroups.</jats:p> Association of oily fish intake, sex, age, BMI and<i>APOE</i>genotype with plasma long-chain<i>n</i>-3 fatty acid composition British Journal of Nutrition |
| spellingShingle | Fisk, Helena L., Irvine, Michael, Miles, Elizabeth A., Lietz, Georg, Mathers, John C., Packard, Chris J., Armah, Christopher K., Kofler, Bettina M., Curtis, Peter J., Minihane, Anne M., Calder, Philip C., British Journal of Nutrition, Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_full | Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_fullStr | Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_full_unstemmed | Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_short | Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| title_sort | association of oily fish intake, sex, age, bmi and<i>apoe</i>genotype with plasma long-chain<i>n</i>-3 fatty acid composition |
| title_unstemmed | Association of oily fish intake, sex, age, BMI andAPOEgenotype with plasma long-chainn-3 fatty acid composition |
| topic | Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1017/s000711451800106x |