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Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project
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| Zeitschriftentitel: | British Journal of Nutrition |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | British Journal of Nutrition, 115, 2016, 2, S. 202-211 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
|
| Schlagwörter: |
| author_facet |
Hoeller, Ulrich Baur, Manuela Roos, Franz F. Brennan, Lorraine Daniel, Hannelore Fallaize, Rosalind Forster, Hannah Gibney, Eileen R. Gibney, Mike Godlewska, Magdalena Hartwig, Kai Kolossa, Silvia Lambrinou, Christina P. Livingstone, Katherine M. Lovegrove, Julie A. Macready, Anna L. Manios, Yannis Marsaux, Cyril F. M. Martinez, J. Alfredo Celis-Morales, Carlos Moschonis, George Navas-Carretero, Santiago O’Donovan, Clare B. San-Cristobal, Rodrigo Saris, Wim H. M. Surwiłło, Agnieszka Traczyk, Iwona Tsirigoti, Lydia Walsh, Marianne C. Woolhead, Clara Mathers, John C. Weber, Peter Hoeller, Ulrich Baur, Manuela Roos, Franz F. Brennan, Lorraine Daniel, Hannelore Fallaize, Rosalind Forster, Hannah Gibney, Eileen R. Gibney, Mike Godlewska, Magdalena Hartwig, Kai Kolossa, Silvia Lambrinou, Christina P. Livingstone, Katherine M. Lovegrove, Julie A. Macready, Anna L. Manios, Yannis Marsaux, Cyril F. M. Martinez, J. Alfredo Celis-Morales, Carlos Moschonis, George Navas-Carretero, Santiago O’Donovan, Clare B. San-Cristobal, Rodrigo Saris, Wim H. M. Surwiłło, Agnieszka Traczyk, Iwona Tsirigoti, Lydia Walsh, Marianne C. Woolhead, Clara Mathers, John C. Weber, Peter |
|---|---|
| author |
Hoeller, Ulrich Baur, Manuela Roos, Franz F. Brennan, Lorraine Daniel, Hannelore Fallaize, Rosalind Forster, Hannah Gibney, Eileen R. Gibney, Mike Godlewska, Magdalena Hartwig, Kai Kolossa, Silvia Lambrinou, Christina P. Livingstone, Katherine M. Lovegrove, Julie A. Macready, Anna L. Manios, Yannis Marsaux, Cyril F. M. Martinez, J. Alfredo Celis-Morales, Carlos Moschonis, George Navas-Carretero, Santiago O’Donovan, Clare B. San-Cristobal, Rodrigo Saris, Wim H. M. Surwiłło, Agnieszka Traczyk, Iwona Tsirigoti, Lydia Walsh, Marianne C. Woolhead, Clara Mathers, John C. Weber, Peter |
| spellingShingle |
Hoeller, Ulrich Baur, Manuela Roos, Franz F. Brennan, Lorraine Daniel, Hannelore Fallaize, Rosalind Forster, Hannah Gibney, Eileen R. Gibney, Mike Godlewska, Magdalena Hartwig, Kai Kolossa, Silvia Lambrinou, Christina P. Livingstone, Katherine M. Lovegrove, Julie A. Macready, Anna L. Manios, Yannis Marsaux, Cyril F. M. Martinez, J. Alfredo Celis-Morales, Carlos Moschonis, George Navas-Carretero, Santiago O’Donovan, Clare B. San-Cristobal, Rodrigo Saris, Wim H. M. Surwiłło, Agnieszka Traczyk, Iwona Tsirigoti, Lydia Walsh, Marianne C. Woolhead, Clara Mathers, John C. Weber, Peter British Journal of Nutrition Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project Nutrition and Dietetics Medicine (miscellaneous) |
| author_sort |
hoeller, ulrich |
| spelling |
Hoeller, Ulrich Baur, Manuela Roos, Franz F. Brennan, Lorraine Daniel, Hannelore Fallaize, Rosalind Forster, Hannah Gibney, Eileen R. Gibney, Mike Godlewska, Magdalena Hartwig, Kai Kolossa, Silvia Lambrinou, Christina P. Livingstone, Katherine M. Lovegrove, Julie A. Macready, Anna L. Manios, Yannis Marsaux, Cyril F. M. Martinez, J. Alfredo Celis-Morales, Carlos Moschonis, George Navas-Carretero, Santiago O’Donovan, Clare B. San-Cristobal, Rodrigo Saris, Wim H. M. Surwiłło, Agnieszka Traczyk, Iwona Tsirigoti, Lydia Walsh, Marianne C. Woolhead, Clara Mathers, John C. Weber, Peter 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s0007114515004298 <jats:title>Abstract</jats:title><jats:p>An efficient and robust method to measure vitamin D (25-hydroxy vitamin D<jats:sub>3</jats:sub>(25(OH)D<jats:sub>3</jats:sub>) and 25-hydroxy vitamin D<jats:sub>2</jats:sub>in dried blood spots (DBS) has been developed and applied in the pan-European multi-centre, internet-based, personalised nutrition intervention study Food4Me. The method includes calibration with blood containing endogenous 25(OH)D<jats:sub>3</jats:sub>, spotted as DBS and corrected for haematocrit content. The methodology was validated following international standards. The performance characteristics did not reach those of the current gold standard liquid chromatography-MS/MS in plasma for all parameters, but were found to be very suitable for status-level determination under field conditions. DBS sample quality was very high, and 3778 measurements of 25(OH)D<jats:sub>3</jats:sub>were obtained from 1465 participants. The study centre and the season within the study centre were very good predictors of 25(OH)D<jats:sub>3</jats:sub>levels (<jats:italic>P</jats:italic><0·001 for each case). Seasonal effects were modelled by fitting a sine function with a minimum 25(OH)D<jats:sub>3</jats:sub>level on 20 January and a maximum on 21 July. The seasonal amplitude varied from centre to centre. The largest difference between winter and summer levels was found in Germany and the smallest in Poland. The model was cross-validated to determine the consistency of the predictions and the performance of the DBS method. The Pearson’s correlation between the measured values and the predicted values was<jats:italic>r</jats:italic>0·65, and the<jats:sc>sd</jats:sc>of their differences was 21·2 nmol/l. This includes the analytical variation and the biological variation within subjects. Overall, DBS obtained by unsupervised sampling of the participants at home was a viable methodology for obtaining vitamin D status information in a large nutritional study.</jats:p> Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project British Journal of Nutrition |
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| title |
Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_unstemmed |
Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_full |
Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_fullStr |
Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_full_unstemmed |
Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_short |
Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_sort |
application of dried blood spots to determine vitamin d status in a large nutritional study with unsupervised sampling: the food4me project |
| topic |
Nutrition and Dietetics Medicine (miscellaneous) |
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http://dx.doi.org/10.1017/s0007114515004298 |
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2016 |
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202-211 |
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<jats:title>Abstract</jats:title><jats:p>An efficient and robust method to measure vitamin D (25-hydroxy vitamin D<jats:sub>3</jats:sub>(25(OH)D<jats:sub>3</jats:sub>) and 25-hydroxy vitamin D<jats:sub>2</jats:sub>in dried blood spots (DBS) has been developed and applied in the pan-European multi-centre, internet-based, personalised nutrition intervention study Food4Me. The method includes calibration with blood containing endogenous 25(OH)D<jats:sub>3</jats:sub>, spotted as DBS and corrected for haematocrit content. The methodology was validated following international standards. The performance characteristics did not reach those of the current gold standard liquid chromatography-MS/MS in plasma for all parameters, but were found to be very suitable for status-level determination under field conditions. DBS sample quality was very high, and 3778 measurements of 25(OH)D<jats:sub>3</jats:sub>were obtained from 1465 participants. The study centre and the season within the study centre were very good predictors of 25(OH)D<jats:sub>3</jats:sub>levels (<jats:italic>P</jats:italic><0·001 for each case). Seasonal effects were modelled by fitting a sine function with a minimum 25(OH)D<jats:sub>3</jats:sub>level on 20 January and a maximum on 21 July. The seasonal amplitude varied from centre to centre. The largest difference between winter and summer levels was found in Germany and the smallest in Poland. The model was cross-validated to determine the consistency of the predictions and the performance of the DBS method. The Pearson’s correlation between the measured values and the predicted values was<jats:italic>r</jats:italic>0·65, and the<jats:sc>sd</jats:sc>of their differences was 21·2 nmol/l. This includes the analytical variation and the biological variation within subjects. Overall, DBS obtained by unsupervised sampling of the participants at home was a viable methodology for obtaining vitamin D status information in a large nutritional study.</jats:p> |
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| author | Hoeller, Ulrich, Baur, Manuela, Roos, Franz F., Brennan, Lorraine, Daniel, Hannelore, Fallaize, Rosalind, Forster, Hannah, Gibney, Eileen R., Gibney, Mike, Godlewska, Magdalena, Hartwig, Kai, Kolossa, Silvia, Lambrinou, Christina P., Livingstone, Katherine M., Lovegrove, Julie A., Macready, Anna L., Manios, Yannis, Marsaux, Cyril F. M., Martinez, J. Alfredo, Celis-Morales, Carlos, Moschonis, George, Navas-Carretero, Santiago, O’Donovan, Clare B., San-Cristobal, Rodrigo, Saris, Wim H. M., Surwiłło, Agnieszka, Traczyk, Iwona, Tsirigoti, Lydia, Walsh, Marianne C., Woolhead, Clara, Mathers, John C., Weber, Peter |
| author_facet | Hoeller, Ulrich, Baur, Manuela, Roos, Franz F., Brennan, Lorraine, Daniel, Hannelore, Fallaize, Rosalind, Forster, Hannah, Gibney, Eileen R., Gibney, Mike, Godlewska, Magdalena, Hartwig, Kai, Kolossa, Silvia, Lambrinou, Christina P., Livingstone, Katherine M., Lovegrove, Julie A., Macready, Anna L., Manios, Yannis, Marsaux, Cyril F. M., Martinez, J. Alfredo, Celis-Morales, Carlos, Moschonis, George, Navas-Carretero, Santiago, O’Donovan, Clare B., San-Cristobal, Rodrigo, Saris, Wim H. M., Surwiłło, Agnieszka, Traczyk, Iwona, Tsirigoti, Lydia, Walsh, Marianne C., Woolhead, Clara, Mathers, John C., Weber, Peter, Hoeller, Ulrich, Baur, Manuela, Roos, Franz F., Brennan, Lorraine, Daniel, Hannelore, Fallaize, Rosalind, Forster, Hannah, Gibney, Eileen R., Gibney, Mike, Godlewska, Magdalena, Hartwig, Kai, Kolossa, Silvia, Lambrinou, Christina P., Livingstone, Katherine M., Lovegrove, Julie A., Macready, Anna L., Manios, Yannis, Marsaux, Cyril F. M., Martinez, J. Alfredo, Celis-Morales, Carlos, Moschonis, George, Navas-Carretero, Santiago, O’Donovan, Clare B., San-Cristobal, Rodrigo, Saris, Wim H. M., Surwiłło, Agnieszka, Traczyk, Iwona, Tsirigoti, Lydia, Walsh, Marianne C., Woolhead, Clara, Mathers, John C., Weber, Peter |
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| description | <jats:title>Abstract</jats:title><jats:p>An efficient and robust method to measure vitamin D (25-hydroxy vitamin D<jats:sub>3</jats:sub>(25(OH)D<jats:sub>3</jats:sub>) and 25-hydroxy vitamin D<jats:sub>2</jats:sub>in dried blood spots (DBS) has been developed and applied in the pan-European multi-centre, internet-based, personalised nutrition intervention study Food4Me. The method includes calibration with blood containing endogenous 25(OH)D<jats:sub>3</jats:sub>, spotted as DBS and corrected for haematocrit content. The methodology was validated following international standards. The performance characteristics did not reach those of the current gold standard liquid chromatography-MS/MS in plasma for all parameters, but were found to be very suitable for status-level determination under field conditions. DBS sample quality was very high, and 3778 measurements of 25(OH)D<jats:sub>3</jats:sub>were obtained from 1465 participants. The study centre and the season within the study centre were very good predictors of 25(OH)D<jats:sub>3</jats:sub>levels (<jats:italic>P</jats:italic><0·001 for each case). Seasonal effects were modelled by fitting a sine function with a minimum 25(OH)D<jats:sub>3</jats:sub>level on 20 January and a maximum on 21 July. The seasonal amplitude varied from centre to centre. The largest difference between winter and summer levels was found in Germany and the smallest in Poland. The model was cross-validated to determine the consistency of the predictions and the performance of the DBS method. The Pearson’s correlation between the measured values and the predicted values was<jats:italic>r</jats:italic>0·65, and the<jats:sc>sd</jats:sc>of their differences was 21·2 nmol/l. This includes the analytical variation and the biological variation within subjects. Overall, DBS obtained by unsupervised sampling of the participants at home was a viable methodology for obtaining vitamin D status information in a large nutritional study.</jats:p> |
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| spelling | Hoeller, Ulrich Baur, Manuela Roos, Franz F. Brennan, Lorraine Daniel, Hannelore Fallaize, Rosalind Forster, Hannah Gibney, Eileen R. Gibney, Mike Godlewska, Magdalena Hartwig, Kai Kolossa, Silvia Lambrinou, Christina P. Livingstone, Katherine M. Lovegrove, Julie A. Macready, Anna L. Manios, Yannis Marsaux, Cyril F. M. Martinez, J. Alfredo Celis-Morales, Carlos Moschonis, George Navas-Carretero, Santiago O’Donovan, Clare B. San-Cristobal, Rodrigo Saris, Wim H. M. Surwiłło, Agnieszka Traczyk, Iwona Tsirigoti, Lydia Walsh, Marianne C. Woolhead, Clara Mathers, John C. Weber, Peter 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s0007114515004298 <jats:title>Abstract</jats:title><jats:p>An efficient and robust method to measure vitamin D (25-hydroxy vitamin D<jats:sub>3</jats:sub>(25(OH)D<jats:sub>3</jats:sub>) and 25-hydroxy vitamin D<jats:sub>2</jats:sub>in dried blood spots (DBS) has been developed and applied in the pan-European multi-centre, internet-based, personalised nutrition intervention study Food4Me. The method includes calibration with blood containing endogenous 25(OH)D<jats:sub>3</jats:sub>, spotted as DBS and corrected for haematocrit content. The methodology was validated following international standards. The performance characteristics did not reach those of the current gold standard liquid chromatography-MS/MS in plasma for all parameters, but were found to be very suitable for status-level determination under field conditions. DBS sample quality was very high, and 3778 measurements of 25(OH)D<jats:sub>3</jats:sub>were obtained from 1465 participants. The study centre and the season within the study centre were very good predictors of 25(OH)D<jats:sub>3</jats:sub>levels (<jats:italic>P</jats:italic><0·001 for each case). Seasonal effects were modelled by fitting a sine function with a minimum 25(OH)D<jats:sub>3</jats:sub>level on 20 January and a maximum on 21 July. The seasonal amplitude varied from centre to centre. The largest difference between winter and summer levels was found in Germany and the smallest in Poland. The model was cross-validated to determine the consistency of the predictions and the performance of the DBS method. The Pearson’s correlation between the measured values and the predicted values was<jats:italic>r</jats:italic>0·65, and the<jats:sc>sd</jats:sc>of their differences was 21·2 nmol/l. This includes the analytical variation and the biological variation within subjects. Overall, DBS obtained by unsupervised sampling of the participants at home was a viable methodology for obtaining vitamin D status information in a large nutritional study.</jats:p> Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project British Journal of Nutrition |
| spellingShingle | Hoeller, Ulrich, Baur, Manuela, Roos, Franz F., Brennan, Lorraine, Daniel, Hannelore, Fallaize, Rosalind, Forster, Hannah, Gibney, Eileen R., Gibney, Mike, Godlewska, Magdalena, Hartwig, Kai, Kolossa, Silvia, Lambrinou, Christina P., Livingstone, Katherine M., Lovegrove, Julie A., Macready, Anna L., Manios, Yannis, Marsaux, Cyril F. M., Martinez, J. Alfredo, Celis-Morales, Carlos, Moschonis, George, Navas-Carretero, Santiago, O’Donovan, Clare B., San-Cristobal, Rodrigo, Saris, Wim H. M., Surwiłło, Agnieszka, Traczyk, Iwona, Tsirigoti, Lydia, Walsh, Marianne C., Woolhead, Clara, Mathers, John C., Weber, Peter, British Journal of Nutrition, Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_full | Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_fullStr | Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_full_unstemmed | Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_short | Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| title_sort | application of dried blood spots to determine vitamin d status in a large nutritional study with unsupervised sampling: the food4me project |
| title_unstemmed | Application of dried blood spots to determine vitamin D status in a large nutritional study with unsupervised sampling: the Food4Me project |
| topic | Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1017/s0007114515004298 |