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Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women
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| Zeitschriftentitel: | British Journal of Nutrition |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| In: | British Journal of Nutrition, 109, 2013, 12, S. 2269-2275 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
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| Schlagwörter: |
| author_facet |
Aarestrup, Julie Kyrø, Cecilie Knudsen, Knud E. B. Weiderpass, Elisabete Christensen, Jane Kristensen, Mette Würtz, Anne M. L. Johnsen, Nina F. Overvad, Kim Tjønneland, Anne Olsen, Anja Aarestrup, Julie Kyrø, Cecilie Knudsen, Knud E. B. Weiderpass, Elisabete Christensen, Jane Kristensen, Mette Würtz, Anne M. L. Johnsen, Nina F. Overvad, Kim Tjønneland, Anne Olsen, Anja |
|---|---|
| author |
Aarestrup, Julie Kyrø, Cecilie Knudsen, Knud E. B. Weiderpass, Elisabete Christensen, Jane Kristensen, Mette Würtz, Anne M. L. Johnsen, Nina F. Overvad, Kim Tjønneland, Anne Olsen, Anja |
| spellingShingle |
Aarestrup, Julie Kyrø, Cecilie Knudsen, Knud E. B. Weiderpass, Elisabete Christensen, Jane Kristensen, Mette Würtz, Anne M. L. Johnsen, Nina F. Overvad, Kim Tjønneland, Anne Olsen, Anja British Journal of Nutrition Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women Nutrition and Dietetics Medicine (miscellaneous) |
| author_sort |
aarestrup, julie |
| spelling |
Aarestrup, Julie Kyrø, Cecilie Knudsen, Knud E. B. Weiderpass, Elisabete Christensen, Jane Kristensen, Mette Würtz, Anne M. L. Johnsen, Nina F. Overvad, Kim Tjønneland, Anne Olsen, Anja 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s0007114512004424 <jats:p>The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case–cohort study in the ‘Diet, Cancer and Health’ cohort. The cohort study included 29 875 women aged 50–64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.</jats:p> Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women British Journal of Nutrition |
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| title |
Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_unstemmed |
Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_full |
Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_fullStr |
Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_full_unstemmed |
Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_short |
Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_sort |
plasma enterolactone and incidence of endometrial cancer in a case–cohort study of danish women |
| topic |
Nutrition and Dietetics Medicine (miscellaneous) |
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http://dx.doi.org/10.1017/s0007114512004424 |
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2013 |
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2269-2275 |
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<jats:p>The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case–cohort study in the ‘Diet, Cancer and Health’ cohort. The cohort study included 29 875 women aged 50–64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.</jats:p> |
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| author | Aarestrup, Julie, Kyrø, Cecilie, Knudsen, Knud E. B., Weiderpass, Elisabete, Christensen, Jane, Kristensen, Mette, Würtz, Anne M. L., Johnsen, Nina F., Overvad, Kim, Tjønneland, Anne, Olsen, Anja |
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| description | <jats:p>The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case–cohort study in the ‘Diet, Cancer and Health’ cohort. The cohort study included 29 875 women aged 50–64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.</jats:p> |
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| spelling | Aarestrup, Julie Kyrø, Cecilie Knudsen, Knud E. B. Weiderpass, Elisabete Christensen, Jane Kristensen, Mette Würtz, Anne M. L. Johnsen, Nina F. Overvad, Kim Tjønneland, Anne Olsen, Anja 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s0007114512004424 <jats:p>The phyto-oestrogen enterolactone has been hypothesised to protect against hormone-dependent cancers, probably through its anti-oestrogenic potential. We investigated whether a higher level of plasma enterolactone was associated with a lower incidence of endometrial cancer in a case–cohort study in the ‘Diet, Cancer and Health’ cohort. The cohort study included 29 875 women aged 50–64 years enrolled between 1993 and 1997. Information on diet and lifestyle was provided by self-administrated questionnaires and blood was drawn from each participant. Time-resolved fluoroimmunoassay was used for biochemical determination of plasma enterolactone. A total of 173 cases and 149 randomly selected cohort members were included. We estimated incidence rate ratio (IRR) and 95 % CI by a Cox proportional hazards model. A 20 nmol/l higher plasma concentration of enterolactone was associated with a non-significant lower risk of endometrial cancer (IRR 0·93, 95 % CI 0·84, 1·04). When excluding women with low enterolactone concentrations (quartile 1) due to potential recent antibiotic use, the association became slightly stronger, but remained non-significant (IRR 0·90, 95 % CI 0·79, 1·02). Menopausal status, hormone replacement therapy or BMI did not modify the association. In conclusion, we found some support for a possible inverse association between plasma enterolactone concentration and endometrial cancer incidence.</jats:p> Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women British Journal of Nutrition |
| spellingShingle | Aarestrup, Julie, Kyrø, Cecilie, Knudsen, Knud E. B., Weiderpass, Elisabete, Christensen, Jane, Kristensen, Mette, Würtz, Anne M. L., Johnsen, Nina F., Overvad, Kim, Tjønneland, Anne, Olsen, Anja, British Journal of Nutrition, Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_full | Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_fullStr | Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_full_unstemmed | Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_short | Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| title_sort | plasma enterolactone and incidence of endometrial cancer in a case–cohort study of danish women |
| title_unstemmed | Plasma enterolactone and incidence of endometrial cancer in a case–cohort study of Danish women |
| topic | Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1017/s0007114512004424 |