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Absence of intestinal microbiota does not protect mice from diet-induced obesity
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| Zeitschriftentitel: | British Journal of Nutrition |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | British Journal of Nutrition, 104, 2010, 6, S. 919-929 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Cambridge University Press (CUP)
|
| Schlagwörter: |
| author_facet |
Fleissner, Christine K. Huebel, Nora Abd El-Bary, Mohamed Mostafa Loh, Gunnar Klaus, Susanne Blaut, Michael Fleissner, Christine K. Huebel, Nora Abd El-Bary, Mohamed Mostafa Loh, Gunnar Klaus, Susanne Blaut, Michael |
|---|---|
| author |
Fleissner, Christine K. Huebel, Nora Abd El-Bary, Mohamed Mostafa Loh, Gunnar Klaus, Susanne Blaut, Michael |
| spellingShingle |
Fleissner, Christine K. Huebel, Nora Abd El-Bary, Mohamed Mostafa Loh, Gunnar Klaus, Susanne Blaut, Michael British Journal of Nutrition Absence of intestinal microbiota does not protect mice from diet-induced obesity Nutrition and Dietetics Medicine (miscellaneous) |
| author_sort |
fleissner, christine k. |
| spelling |
Fleissner, Christine K. Huebel, Nora Abd El-Bary, Mohamed Mostafa Loh, Gunnar Klaus, Susanne Blaut, Michael 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s0007114510001303 <jats:p>The gut microbiota has been implicated in host nutrient absorption and energy homeostasis. We studied the influence of different diets on body composition in germ-free (GF) and conventional (CV) mice. GF and CV male adult C3H mice were fed<jats:italic>ad libitum</jats:italic>a semi-synthetic low-fat diet (LFD; carbohydrate–protein–fat ratio: 41:42:17; 19·8 kJ/g), a high-fat diet (HFD; 41:16:43; 21·4 kJ/g) or a commercial Western diet (WD; 41:19:41; 21·5 kJ/g). There was no difference in body weight gain between GF and CV mice on the LFD. On the HFD, GF mice gained more body weight and body fat than CV mice, and had lower energy expenditure. GF mice on the WD gained significantly less body fat than GF mice on the HFD. GF mice on both HFD and WD showed increased intestinal mRNA expression of fasting-induced adipose factor/angiopoietin-like protein 4 (<jats:italic>Fiaf/Angptl4</jats:italic>), but they showed no major changes in circulating Fiaf/Angptl4 compared with CV mice. The faecal microbiota composition of the CV mice differed between diets: the proportion of Firmicutes increased on both HFD and WD at the expense of the Bacteroidetes. This increase in the Firmicutes was mainly due to the proliferation of one family within this phylum: the Erysipelotrichaceae. We conclude that the absence of gut microbiota does not provide a general protection from diet-induced obesity, that intestinal production of Fiaf/Angptl4 does not play a causal role in gut microbiota-mediated effects on fat storage and that diet composition affects gut microbial composition to larger extent than previously thought.</jats:p> Absence of intestinal microbiota does not protect mice from diet-induced obesity British Journal of Nutrition |
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| title |
Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_unstemmed |
Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_full |
Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_fullStr |
Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_full_unstemmed |
Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_short |
Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_sort |
absence of intestinal microbiota does not protect mice from diet-induced obesity |
| topic |
Nutrition and Dietetics Medicine (miscellaneous) |
| url |
http://dx.doi.org/10.1017/s0007114510001303 |
| publishDate |
2010 |
| physical |
919-929 |
| description |
<jats:p>The gut microbiota has been implicated in host nutrient absorption and energy homeostasis. We studied the influence of different diets on body composition in germ-free (GF) and conventional (CV) mice. GF and CV male adult C3H mice were fed<jats:italic>ad libitum</jats:italic>a semi-synthetic low-fat diet (LFD; carbohydrate–protein–fat ratio: 41:42:17; 19·8 kJ/g), a high-fat diet (HFD; 41:16:43; 21·4 kJ/g) or a commercial Western diet (WD; 41:19:41; 21·5 kJ/g). There was no difference in body weight gain between GF and CV mice on the LFD. On the HFD, GF mice gained more body weight and body fat than CV mice, and had lower energy expenditure. GF mice on the WD gained significantly less body fat than GF mice on the HFD. GF mice on both HFD and WD showed increased intestinal mRNA expression of fasting-induced adipose factor/angiopoietin-like protein 4 (<jats:italic>Fiaf/Angptl4</jats:italic>), but they showed no major changes in circulating Fiaf/Angptl4 compared with CV mice. The faecal microbiota composition of the CV mice differed between diets: the proportion of Firmicutes increased on both HFD and WD at the expense of the Bacteroidetes. This increase in the Firmicutes was mainly due to the proliferation of one family within this phylum: the Erysipelotrichaceae. We conclude that the absence of gut microbiota does not provide a general protection from diet-induced obesity, that intestinal production of Fiaf/Angptl4 does not play a causal role in gut microbiota-mediated effects on fat storage and that diet composition affects gut microbial composition to larger extent than previously thought.</jats:p> |
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| author | Fleissner, Christine K., Huebel, Nora, Abd El-Bary, Mohamed Mostafa, Loh, Gunnar, Klaus, Susanne, Blaut, Michael |
| author_facet | Fleissner, Christine K., Huebel, Nora, Abd El-Bary, Mohamed Mostafa, Loh, Gunnar, Klaus, Susanne, Blaut, Michael, Fleissner, Christine K., Huebel, Nora, Abd El-Bary, Mohamed Mostafa, Loh, Gunnar, Klaus, Susanne, Blaut, Michael |
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| description | <jats:p>The gut microbiota has been implicated in host nutrient absorption and energy homeostasis. We studied the influence of different diets on body composition in germ-free (GF) and conventional (CV) mice. GF and CV male adult C3H mice were fed<jats:italic>ad libitum</jats:italic>a semi-synthetic low-fat diet (LFD; carbohydrate–protein–fat ratio: 41:42:17; 19·8 kJ/g), a high-fat diet (HFD; 41:16:43; 21·4 kJ/g) or a commercial Western diet (WD; 41:19:41; 21·5 kJ/g). There was no difference in body weight gain between GF and CV mice on the LFD. On the HFD, GF mice gained more body weight and body fat than CV mice, and had lower energy expenditure. GF mice on the WD gained significantly less body fat than GF mice on the HFD. GF mice on both HFD and WD showed increased intestinal mRNA expression of fasting-induced adipose factor/angiopoietin-like protein 4 (<jats:italic>Fiaf/Angptl4</jats:italic>), but they showed no major changes in circulating Fiaf/Angptl4 compared with CV mice. The faecal microbiota composition of the CV mice differed between diets: the proportion of Firmicutes increased on both HFD and WD at the expense of the Bacteroidetes. This increase in the Firmicutes was mainly due to the proliferation of one family within this phylum: the Erysipelotrichaceae. We conclude that the absence of gut microbiota does not provide a general protection from diet-induced obesity, that intestinal production of Fiaf/Angptl4 does not play a causal role in gut microbiota-mediated effects on fat storage and that diet composition affects gut microbial composition to larger extent than previously thought.</jats:p> |
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| imprint_str_mv | Cambridge University Press (CUP), 2010 |
| institution | DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15 |
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| spelling | Fleissner, Christine K. Huebel, Nora Abd El-Bary, Mohamed Mostafa Loh, Gunnar Klaus, Susanne Blaut, Michael 0007-1145 1475-2662 Cambridge University Press (CUP) Nutrition and Dietetics Medicine (miscellaneous) http://dx.doi.org/10.1017/s0007114510001303 <jats:p>The gut microbiota has been implicated in host nutrient absorption and energy homeostasis. We studied the influence of different diets on body composition in germ-free (GF) and conventional (CV) mice. GF and CV male adult C3H mice were fed<jats:italic>ad libitum</jats:italic>a semi-synthetic low-fat diet (LFD; carbohydrate–protein–fat ratio: 41:42:17; 19·8 kJ/g), a high-fat diet (HFD; 41:16:43; 21·4 kJ/g) or a commercial Western diet (WD; 41:19:41; 21·5 kJ/g). There was no difference in body weight gain between GF and CV mice on the LFD. On the HFD, GF mice gained more body weight and body fat than CV mice, and had lower energy expenditure. GF mice on the WD gained significantly less body fat than GF mice on the HFD. GF mice on both HFD and WD showed increased intestinal mRNA expression of fasting-induced adipose factor/angiopoietin-like protein 4 (<jats:italic>Fiaf/Angptl4</jats:italic>), but they showed no major changes in circulating Fiaf/Angptl4 compared with CV mice. The faecal microbiota composition of the CV mice differed between diets: the proportion of Firmicutes increased on both HFD and WD at the expense of the Bacteroidetes. This increase in the Firmicutes was mainly due to the proliferation of one family within this phylum: the Erysipelotrichaceae. We conclude that the absence of gut microbiota does not provide a general protection from diet-induced obesity, that intestinal production of Fiaf/Angptl4 does not play a causal role in gut microbiota-mediated effects on fat storage and that diet composition affects gut microbial composition to larger extent than previously thought.</jats:p> Absence of intestinal microbiota does not protect mice from diet-induced obesity British Journal of Nutrition |
| spellingShingle | Fleissner, Christine K., Huebel, Nora, Abd El-Bary, Mohamed Mostafa, Loh, Gunnar, Klaus, Susanne, Blaut, Michael, British Journal of Nutrition, Absence of intestinal microbiota does not protect mice from diet-induced obesity, Nutrition and Dietetics, Medicine (miscellaneous) |
| title | Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_full | Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_fullStr | Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_full_unstemmed | Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_short | Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_sort | absence of intestinal microbiota does not protect mice from diet-induced obesity |
| title_unstemmed | Absence of intestinal microbiota does not protect mice from diet-induced obesity |
| topic | Nutrition and Dietetics, Medicine (miscellaneous) |
| url | http://dx.doi.org/10.1017/s0007114510001303 |