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Characteristic molecular vibrations of adenosine receptor ligands
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | FEBS Letters, 589, 2015, 4, S. 548-552 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Chee, Hyun Keun Yang, Jin-San Joung, Je-Gun Zhang, Byoung-Tak Oh, S. June Chee, Hyun Keun Yang, Jin-San Joung, Je-Gun Zhang, Byoung-Tak Oh, S. June |
|---|---|
| author |
Chee, Hyun Keun Yang, Jin-San Joung, Je-Gun Zhang, Byoung-Tak Oh, S. June |
| spellingShingle |
Chee, Hyun Keun Yang, Jin-San Joung, Je-Gun Zhang, Byoung-Tak Oh, S. June FEBS Letters Characteristic molecular vibrations of adenosine receptor ligands Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
chee, hyun keun |
| spelling |
Chee, Hyun Keun Yang, Jin-San Joung, Je-Gun Zhang, Byoung-Tak Oh, S. June 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/j.febslet.2015.01.024 <jats:p>Although the regulation of membrane receptor activation is known to be crucial for molecular signal transduction, the molecular mechanism underlying receptor activation is not fully elucidated. Here we study the physicochemical nature of membrane receptor behavior by investigating the characteristic molecular vibrations of receptor ligands using computational chemistry and informatics methods. By using information gain, <jats:italic>t</jats:italic>‐tests, and support vector machines, we have identified highly informative features of adenosine receptor (AdoR) ligand and corresponding functional amino acid residues such as Asn (6.55) of AdoR that has informative significance and is indispensable for ligand recognition of AdoRs. These findings may provide new perspectives and insights into the fundamental mechanism of class A G protein‐coupled receptor activation.</jats:p> Characteristic molecular vibrations of adenosine receptor ligands FEBS Letters |
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Wiley, 2015 |
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| title |
Characteristic molecular vibrations of adenosine receptor ligands |
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Characteristic molecular vibrations of adenosine receptor ligands |
| title_full |
Characteristic molecular vibrations of adenosine receptor ligands |
| title_fullStr |
Characteristic molecular vibrations of adenosine receptor ligands |
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Characteristic molecular vibrations of adenosine receptor ligands |
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Characteristic molecular vibrations of adenosine receptor ligands |
| title_sort |
characteristic molecular vibrations of adenosine receptor ligands |
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Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
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http://dx.doi.org/10.1016/j.febslet.2015.01.024 |
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2015 |
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548-552 |
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<jats:p>Although the regulation of membrane receptor activation is known to be crucial for molecular signal transduction, the molecular mechanism underlying receptor activation is not fully elucidated. Here we study the physicochemical nature of membrane receptor behavior by investigating the characteristic molecular vibrations of receptor ligands using computational chemistry and informatics methods. By using information gain, <jats:italic>t</jats:italic>‐tests, and support vector machines, we have identified highly informative features of adenosine receptor (AdoR) ligand and corresponding functional amino acid residues such as Asn (6.55) of AdoR that has informative significance and is indispensable for ligand recognition of AdoRs. These findings may provide new perspectives and insights into the fundamental mechanism of class A G protein‐coupled receptor activation.</jats:p> |
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| author | Chee, Hyun Keun, Yang, Jin-San, Joung, Je-Gun, Zhang, Byoung-Tak, Oh, S. June |
| author_facet | Chee, Hyun Keun, Yang, Jin-San, Joung, Je-Gun, Zhang, Byoung-Tak, Oh, S. June, Chee, Hyun Keun, Yang, Jin-San, Joung, Je-Gun, Zhang, Byoung-Tak, Oh, S. June |
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| container_title | FEBS Letters |
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| description | <jats:p>Although the regulation of membrane receptor activation is known to be crucial for molecular signal transduction, the molecular mechanism underlying receptor activation is not fully elucidated. Here we study the physicochemical nature of membrane receptor behavior by investigating the characteristic molecular vibrations of receptor ligands using computational chemistry and informatics methods. By using information gain, <jats:italic>t</jats:italic>‐tests, and support vector machines, we have identified highly informative features of adenosine receptor (AdoR) ligand and corresponding functional amino acid residues such as Asn (6.55) of AdoR that has informative significance and is indispensable for ligand recognition of AdoRs. These findings may provide new perspectives and insights into the fundamental mechanism of class A G protein‐coupled receptor activation.</jats:p> |
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| physical | 548-552 |
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| source_id | 49 |
| spelling | Chee, Hyun Keun Yang, Jin-San Joung, Je-Gun Zhang, Byoung-Tak Oh, S. June 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/j.febslet.2015.01.024 <jats:p>Although the regulation of membrane receptor activation is known to be crucial for molecular signal transduction, the molecular mechanism underlying receptor activation is not fully elucidated. Here we study the physicochemical nature of membrane receptor behavior by investigating the characteristic molecular vibrations of receptor ligands using computational chemistry and informatics methods. By using information gain, <jats:italic>t</jats:italic>‐tests, and support vector machines, we have identified highly informative features of adenosine receptor (AdoR) ligand and corresponding functional amino acid residues such as Asn (6.55) of AdoR that has informative significance and is indispensable for ligand recognition of AdoRs. These findings may provide new perspectives and insights into the fundamental mechanism of class A G protein‐coupled receptor activation.</jats:p> Characteristic molecular vibrations of adenosine receptor ligands FEBS Letters |
| spellingShingle | Chee, Hyun Keun, Yang, Jin-San, Joung, Je-Gun, Zhang, Byoung-Tak, Oh, S. June, FEBS Letters, Characteristic molecular vibrations of adenosine receptor ligands, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Characteristic molecular vibrations of adenosine receptor ligands |
| title_full | Characteristic molecular vibrations of adenosine receptor ligands |
| title_fullStr | Characteristic molecular vibrations of adenosine receptor ligands |
| title_full_unstemmed | Characteristic molecular vibrations of adenosine receptor ligands |
| title_short | Characteristic molecular vibrations of adenosine receptor ligands |
| title_sort | characteristic molecular vibrations of adenosine receptor ligands |
| title_unstemmed | Characteristic molecular vibrations of adenosine receptor ligands |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/j.febslet.2015.01.024 |