Eintrag weiter verarbeiten
Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells
Gespeichert in:
| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | FEBS Letters, 361, 1995, 1, S. 118-122 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Karikó, Katalin Rosenbaum, Helga Kuo, Alice Zurier, Robert B. Barnathan, Elliot S. Karikó, Katalin Rosenbaum, Helga Kuo, Alice Zurier, Robert B. Barnathan, Elliot S. |
|---|---|
| author |
Karikó, Katalin Rosenbaum, Helga Kuo, Alice Zurier, Robert B. Barnathan, Elliot S. |
| spellingShingle |
Karikó, Katalin Rosenbaum, Helga Kuo, Alice Zurier, Robert B. Barnathan, Elliot S. FEBS Letters Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
karikó, katalin |
| spelling |
Karikó, Katalin Rosenbaum, Helga Kuo, Alice Zurier, Robert B. Barnathan, Elliot S. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(95)00170-e <jats:p>To determine whether unsaturated fatty acids induce changes in the mRNA level of plasminogen activator inhibitor type‐1 (PAI‐1), Northern analyses were performed on human umbilical vein endothelial cells (HUVEC) and vascular smooth muscle cells that were treated with two common fatty acids. Supplementation of cultured HUVEC with docosahexanoic acid (DHA) or with dihomogamma linolenic acid (DGLA), resulted in a concentration dependent, specific increase of the PAI‐1 transcript levels, which was detectable within 2 h. DHA and DGLA treatment of smooth muscle cells did not result in changes in the PAI‐1 mRNA levels. Homology search of the upstream regulatory region of the PAI‐1 gene sequences identified a consensus nucleotide sequence for a fatty acid‐responsive element. Our results indicate that unsaturated fatty acids selectively increase PAI‐1 mRNA levels in endothelial cells, the primary source of circulating PAI‐1 in vivo.</jats:p> Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells FEBS Letters |
| doi_str_mv |
10.1016/0014-5793(95)00170-e |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Chemie und Pharmazie Physik |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi8wMDE0LTU3OTMoOTUpMDAxNzAtZQ |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi8wMDE0LTU3OTMoOTUpMDAxNzAtZQ |
| institution |
DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-Zwi2 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
Wiley, 1995 |
| imprint_str_mv |
Wiley, 1995 |
| issn |
1873-3468 0014-5793 |
| issn_str_mv |
1873-3468 0014-5793 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
kariko1995stimulatoryeffectofunsaturatedfattyacidsonthelevelofplasminogenactivatorinhibitor1mrnainculturedhumanendothelialcells |
| publishDateSort |
1995 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
FEBS Letters |
| source_id |
49 |
| title |
Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_unstemmed |
Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_full |
Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_fullStr |
Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_full_unstemmed |
Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_short |
Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_sort |
stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mrna in cultured human endothelial cells |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1016/0014-5793(95)00170-e |
| publishDate |
1995 |
| physical |
118-122 |
| description |
<jats:p>To determine whether unsaturated fatty acids induce changes in the mRNA level of plasminogen activator inhibitor type‐1 (PAI‐1), Northern analyses were performed on human umbilical vein endothelial cells (HUVEC) and vascular smooth muscle cells that were treated with two common fatty acids. Supplementation of cultured HUVEC with docosahexanoic acid (DHA) or with dihomogamma linolenic acid (DGLA), resulted in a concentration dependent, specific increase of the PAI‐1 transcript levels, which was detectable within 2 h. DHA and DGLA treatment of smooth muscle cells did not result in changes in the PAI‐1 mRNA levels. Homology search of the upstream regulatory region of the PAI‐1 gene sequences identified a consensus nucleotide sequence for a fatty acid‐responsive element. Our results indicate that unsaturated fatty acids selectively increase PAI‐1 mRNA levels in endothelial cells, the primary source of circulating PAI‐1 in vivo.</jats:p> |
| container_issue |
1 |
| container_start_page |
118 |
| container_title |
FEBS Letters |
| container_volume |
361 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792334299693842433 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T14:26:27.774Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Stimulatory+effect+of+unsaturated+fatty+acids+on+the+level+of+plasminogen+activator+inhibitor%E2%80%901+mRNA+in+cultured+human+endothelial+cells&rft.date=1995-03-13&genre=article&issn=1873-3468&volume=361&issue=1&spage=118&epage=122&pages=118-122&jtitle=FEBS+Letters&atitle=Stimulatory+effect+of+unsaturated+fatty+acids+on+the+level+of+plasminogen+activator+inhibitor%E2%80%901+mRNA+in+cultured+human+endothelial+cells&aulast=Barnathan&aufirst=Elliot+S.&rft_id=info%3Adoi%2F10.1016%2F0014-5793%2895%2900170-e&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792334299693842433 |
| author | Karikó, Katalin, Rosenbaum, Helga, Kuo, Alice, Zurier, Robert B., Barnathan, Elliot S. |
| author_facet | Karikó, Katalin, Rosenbaum, Helga, Kuo, Alice, Zurier, Robert B., Barnathan, Elliot S., Karikó, Katalin, Rosenbaum, Helga, Kuo, Alice, Zurier, Robert B., Barnathan, Elliot S. |
| author_sort | karikó, katalin |
| container_issue | 1 |
| container_start_page | 118 |
| container_title | FEBS Letters |
| container_volume | 361 |
| description | <jats:p>To determine whether unsaturated fatty acids induce changes in the mRNA level of plasminogen activator inhibitor type‐1 (PAI‐1), Northern analyses were performed on human umbilical vein endothelial cells (HUVEC) and vascular smooth muscle cells that were treated with two common fatty acids. Supplementation of cultured HUVEC with docosahexanoic acid (DHA) or with dihomogamma linolenic acid (DGLA), resulted in a concentration dependent, specific increase of the PAI‐1 transcript levels, which was detectable within 2 h. DHA and DGLA treatment of smooth muscle cells did not result in changes in the PAI‐1 mRNA levels. Homology search of the upstream regulatory region of the PAI‐1 gene sequences identified a consensus nucleotide sequence for a fatty acid‐responsive element. Our results indicate that unsaturated fatty acids selectively increase PAI‐1 mRNA levels in endothelial cells, the primary source of circulating PAI‐1 in vivo.</jats:p> |
| doi_str_mv | 10.1016/0014-5793(95)00170-e |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Chemie und Pharmazie, Physik |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi8wMDE0LTU3OTMoOTUpMDAxNzAtZQ |
| imprint | Wiley, 1995 |
| imprint_str_mv | Wiley, 1995 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 1873-3468, 0014-5793 |
| issn_str_mv | 1873-3468, 0014-5793 |
| language | English |
| last_indexed | 2024-03-01T14:26:27.774Z |
| match_str | kariko1995stimulatoryeffectofunsaturatedfattyacidsonthelevelofplasminogenactivatorinhibitor1mrnainculturedhumanendothelialcells |
| mega_collection | Wiley (CrossRef) |
| physical | 118-122 |
| publishDate | 1995 |
| publishDateSort | 1995 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Karikó, Katalin Rosenbaum, Helga Kuo, Alice Zurier, Robert B. Barnathan, Elliot S. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(95)00170-e <jats:p>To determine whether unsaturated fatty acids induce changes in the mRNA level of plasminogen activator inhibitor type‐1 (PAI‐1), Northern analyses were performed on human umbilical vein endothelial cells (HUVEC) and vascular smooth muscle cells that were treated with two common fatty acids. Supplementation of cultured HUVEC with docosahexanoic acid (DHA) or with dihomogamma linolenic acid (DGLA), resulted in a concentration dependent, specific increase of the PAI‐1 transcript levels, which was detectable within 2 h. DHA and DGLA treatment of smooth muscle cells did not result in changes in the PAI‐1 mRNA levels. Homology search of the upstream regulatory region of the PAI‐1 gene sequences identified a consensus nucleotide sequence for a fatty acid‐responsive element. Our results indicate that unsaturated fatty acids selectively increase PAI‐1 mRNA levels in endothelial cells, the primary source of circulating PAI‐1 in vivo.</jats:p> Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells FEBS Letters |
| spellingShingle | Karikó, Katalin, Rosenbaum, Helga, Kuo, Alice, Zurier, Robert B., Barnathan, Elliot S., FEBS Letters, Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_full | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_fullStr | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_full_unstemmed | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_short | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| title_sort | stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mrna in cultured human endothelial cells |
| title_unstemmed | Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/0014-5793(95)00170-e |