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The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , |
| In: | FEBS Letters, 323, 1993, 3, S. 191-197 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Jaffrézou, Jean-Pierre Laurent, Guy Jaffrézou, Jean-Pierre Laurent, Guy |
|---|---|
| author |
Jaffrézou, Jean-Pierre Laurent, Guy |
| spellingShingle |
Jaffrézou, Jean-Pierre Laurent, Guy FEBS Letters The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
jaffrézou, jean-pierre |
| spelling |
Jaffrézou, Jean-Pierre Laurent, Guy 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(93)81337-y <jats:p>Pharmacological agents which possess a chemosensitizing activity (i.e. the ability to modulate the multidrug resistance phenotype) can equally enhance ligand‐toxin conjugate cytotoxicity. By confronting results obtained in both fields of research it appears that quite a number of agents, which are structurally unrelated, possess this bilateral effect. We have therefore attempted to provide a brief review of the literature and to discuss a hypothesis by which a common mechanism such as modifications in intracellular vesicle sorting and/or lipid metabolism may be implicated. We believe that these observations may provide clues for future research.</jats:p> The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity FEBS Letters |
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Wiley, 1993 |
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Wiley, 1993 |
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1993 |
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FEBS Letters |
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49 |
| title |
The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_unstemmed |
The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_full |
The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_fullStr |
The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_full_unstemmed |
The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_short |
The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_sort |
the intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1016/0014-5793(93)81337-y |
| publishDate |
1993 |
| physical |
191-197 |
| description |
<jats:p>Pharmacological agents which possess a chemosensitizing activity (i.e. the ability to modulate the multidrug resistance phenotype) can equally enhance ligand‐toxin conjugate cytotoxicity. By confronting results obtained in both fields of research it appears that quite a number of agents, which are structurally unrelated, possess this bilateral effect. We have therefore attempted to provide a brief review of the literature and to discuss a hypothesis by which a common mechanism such as modifications in intracellular vesicle sorting and/or lipid metabolism may be implicated. We believe that these observations may provide clues for future research.</jats:p> |
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| author | Jaffrézou, Jean-Pierre, Laurent, Guy |
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| description | <jats:p>Pharmacological agents which possess a chemosensitizing activity (i.e. the ability to modulate the multidrug resistance phenotype) can equally enhance ligand‐toxin conjugate cytotoxicity. By confronting results obtained in both fields of research it appears that quite a number of agents, which are structurally unrelated, possess this bilateral effect. We have therefore attempted to provide a brief review of the literature and to discuss a hypothesis by which a common mechanism such as modifications in intracellular vesicle sorting and/or lipid metabolism may be implicated. We believe that these observations may provide clues for future research.</jats:p> |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi8wMDE0LTU3OTMoOTMpODEzMzcteQ |
| imprint | Wiley, 1993 |
| imprint_str_mv | Wiley, 1993 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| physical | 191-197 |
| publishDate | 1993 |
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| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Jaffrézou, Jean-Pierre Laurent, Guy 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(93)81337-y <jats:p>Pharmacological agents which possess a chemosensitizing activity (i.e. the ability to modulate the multidrug resistance phenotype) can equally enhance ligand‐toxin conjugate cytotoxicity. By confronting results obtained in both fields of research it appears that quite a number of agents, which are structurally unrelated, possess this bilateral effect. We have therefore attempted to provide a brief review of the literature and to discuss a hypothesis by which a common mechanism such as modifications in intracellular vesicle sorting and/or lipid metabolism may be implicated. We believe that these observations may provide clues for future research.</jats:p> The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity FEBS Letters |
| spellingShingle | Jaffrézou, Jean-Pierre, Laurent, Guy, FEBS Letters, The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_full | The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_fullStr | The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_full_unstemmed | The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_short | The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_sort | the intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| title_unstemmed | The intriguing link between modulation of both multidrug resistance and ligand‐toxin conjugate cytotoxicity |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/0014-5793(93)81337-y |