Eintrag weiter verarbeiten
Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5)
Gespeichert in:
| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | FEBS Letters, 262, 1990, 2, S. 259-262 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Kirsch, Joachim Littauer, Uriel Z. Schmitt, Bertram Prior, Peter Thomas, Leo Betz, Heinrich Kirsch, Joachim Littauer, Uriel Z. Schmitt, Bertram Prior, Peter Thomas, Leo Betz, Heinrich |
|---|---|
| author |
Kirsch, Joachim Littauer, Uriel Z. Schmitt, Bertram Prior, Peter Thomas, Leo Betz, Heinrich |
| spellingShingle |
Kirsch, Joachim Littauer, Uriel Z. Schmitt, Bertram Prior, Peter Thomas, Leo Betz, Heinrich FEBS Letters Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
kirsch, joachim |
| spelling |
Kirsch, Joachim Littauer, Uriel Z. Schmitt, Bertram Prior, Peter Thomas, Leo Betz, Heinrich 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(90)80205-w <jats:p>From cloned DNA, neuraxin has been identified as a tubulin binding protein of predicted molecular weight of 94 kDa. The deduced sequence of the rat protein exhibits high homology to the C‐terminal region of mouse microtubule‐associated protein 5 (MAP5). Here, we show that different neuraxin antibodies recognize MAP5, but fail to detect a protein of 94 kDa, in subcellular and microtubular fractions of the rat central nervous system. Furthermore, tubulin binding by neuraxin was found to be dependent on taxol. These data are consistent with neuraxin corresponding to a C‐terminal fragment of MAP5 that contains a low‐affinity tubulin binding site.</jats:p> Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) FEBS Letters |
| doi_str_mv |
10.1016/0014-5793(90)80205-w |
| facet_avail |
Online Free |
| finc_class_facet |
Chemie und Pharmazie Physik Biologie |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi8wMDE0LTU3OTMoOTApODAyMDUtdw |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi8wMDE0LTU3OTMoOTApODAyMDUtdw |
| institution |
DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 |
| imprint |
Wiley, 1990 |
| imprint_str_mv |
Wiley, 1990 |
| issn |
0014-5793 1873-3468 |
| issn_str_mv |
0014-5793 1873-3468 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
kirsch1990neuraxincorrespondstoacterminalfragmentofmicrotubuleassociatedprotein5map5 |
| publishDateSort |
1990 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
FEBS Letters |
| source_id |
49 |
| title |
Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_unstemmed |
Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_full |
Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_fullStr |
Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_full_unstemmed |
Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_short |
Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_sort |
neuraxin corresponds to a c‐terminal fragment of microtubule‐associated protein 5 (map5) |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1016/0014-5793(90)80205-w |
| publishDate |
1990 |
| physical |
259-262 |
| description |
<jats:p>From cloned DNA, neuraxin has been identified as a tubulin binding protein of predicted molecular weight of 94 kDa. The deduced sequence of the rat protein exhibits high homology to the C‐terminal region of mouse microtubule‐associated protein 5 (MAP5). Here, we show that different neuraxin antibodies recognize MAP5, but fail to detect a protein of 94 kDa, in subcellular and microtubular fractions of the rat central nervous system. Furthermore, tubulin binding by neuraxin was found to be dependent on taxol. These data are consistent with neuraxin corresponding to a C‐terminal fragment of MAP5 that contains a low‐affinity tubulin binding site.</jats:p> |
| container_issue |
2 |
| container_start_page |
259 |
| container_title |
FEBS Letters |
| container_volume |
262 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336845174996992 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:06:55.216Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Neuraxin+corresponds+to+a+C%E2%80%90terminal+fragment+of+microtubule%E2%80%90associated+protein+5+%28MAP5%29&rft.date=1990-03-26&genre=article&issn=1873-3468&volume=262&issue=2&spage=259&epage=262&pages=259-262&jtitle=FEBS+Letters&atitle=Neuraxin+corresponds+to+a+C%E2%80%90terminal+fragment+of+microtubule%E2%80%90associated+protein+5+%28MAP5%29&aulast=Betz&aufirst=Heinrich&rft_id=info%3Adoi%2F10.1016%2F0014-5793%2890%2980205-w&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336845174996992 |
| author | Kirsch, Joachim, Littauer, Uriel Z., Schmitt, Bertram, Prior, Peter, Thomas, Leo, Betz, Heinrich |
| author_facet | Kirsch, Joachim, Littauer, Uriel Z., Schmitt, Bertram, Prior, Peter, Thomas, Leo, Betz, Heinrich, Kirsch, Joachim, Littauer, Uriel Z., Schmitt, Bertram, Prior, Peter, Thomas, Leo, Betz, Heinrich |
| author_sort | kirsch, joachim |
| container_issue | 2 |
| container_start_page | 259 |
| container_title | FEBS Letters |
| container_volume | 262 |
| description | <jats:p>From cloned DNA, neuraxin has been identified as a tubulin binding protein of predicted molecular weight of 94 kDa. The deduced sequence of the rat protein exhibits high homology to the C‐terminal region of mouse microtubule‐associated protein 5 (MAP5). Here, we show that different neuraxin antibodies recognize MAP5, but fail to detect a protein of 94 kDa, in subcellular and microtubular fractions of the rat central nervous system. Furthermore, tubulin binding by neuraxin was found to be dependent on taxol. These data are consistent with neuraxin corresponding to a C‐terminal fragment of MAP5 that contains a low‐affinity tubulin binding site.</jats:p> |
| doi_str_mv | 10.1016/0014-5793(90)80205-w |
| facet_avail | Online, Free |
| finc_class_facet | Chemie und Pharmazie, Physik, Biologie |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi8wMDE0LTU3OTMoOTApODAyMDUtdw |
| imprint | Wiley, 1990 |
| imprint_str_mv | Wiley, 1990 |
| institution | DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
| issn | 0014-5793, 1873-3468 |
| issn_str_mv | 0014-5793, 1873-3468 |
| language | English |
| last_indexed | 2024-03-01T15:06:55.216Z |
| match_str | kirsch1990neuraxincorrespondstoacterminalfragmentofmicrotubuleassociatedprotein5map5 |
| mega_collection | Wiley (CrossRef) |
| physical | 259-262 |
| publishDate | 1990 |
| publishDateSort | 1990 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Kirsch, Joachim Littauer, Uriel Z. Schmitt, Bertram Prior, Peter Thomas, Leo Betz, Heinrich 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(90)80205-w <jats:p>From cloned DNA, neuraxin has been identified as a tubulin binding protein of predicted molecular weight of 94 kDa. The deduced sequence of the rat protein exhibits high homology to the C‐terminal region of mouse microtubule‐associated protein 5 (MAP5). Here, we show that different neuraxin antibodies recognize MAP5, but fail to detect a protein of 94 kDa, in subcellular and microtubular fractions of the rat central nervous system. Furthermore, tubulin binding by neuraxin was found to be dependent on taxol. These data are consistent with neuraxin corresponding to a C‐terminal fragment of MAP5 that contains a low‐affinity tubulin binding site.</jats:p> Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) FEBS Letters |
| spellingShingle | Kirsch, Joachim, Littauer, Uriel Z., Schmitt, Bertram, Prior, Peter, Thomas, Leo, Betz, Heinrich, FEBS Letters, Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5), Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_full | Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_fullStr | Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_full_unstemmed | Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_short | Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| title_sort | neuraxin corresponds to a c‐terminal fragment of microtubule‐associated protein 5 (map5) |
| title_unstemmed | Neuraxin corresponds to a C‐terminal fragment of microtubule‐associated protein 5 (MAP5) |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/0014-5793(90)80205-w |