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Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , |
| In: | FEBS Letters, 234, 1988, 2, S. 321-325 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Patel, Harish M. Wild, Arthur E. Patel, Harish M. Wild, Arthur E. |
|---|---|
| author |
Patel, Harish M. Wild, Arthur E. |
| spellingShingle |
Patel, Harish M. Wild, Arthur E. FEBS Letters Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
patel, harish m. |
| spelling |
Patel, Harish M. Wild, Arthur E. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(88)80108-x <jats:p>Drug carriers such as liposomes are not readily transported across cellular barriers that constitute epithelia. However, certain epithelia (rabbit yolk sac endoderm and enterocytes of suckling rat gut proximal small intestine) are well known to transcytose maternal IgG by Fc receptor‐mediated endocytic events. We have shown that coating liposomes with appropriate IgG enhances their transport across these epithelia, as measured both by radioactivity indicative of liposomal membrane or entrapped <jats:sup>125</jats:sup>I‐PVP and [<jats:sup>3</jats:sup>H]inulin, and by the hypoglycemic effect of entrapped insulin. It is suggested that these transported liposomes follow a pathway of transcytosis in clathrin‐coated vesicles, thus escaping lysosomal degradation.</jats:p> Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers FEBS Letters |
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10.1016/0014-5793(88)80108-x |
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Wiley, 1988 |
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Wiley, 1988 |
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0014-5793 1873-3468 |
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0014-5793 1873-3468 |
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1988 |
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Wiley |
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FEBS Letters |
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49 |
| title |
Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_unstemmed |
Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_full |
Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_fullStr |
Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_full_unstemmed |
Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_short |
Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_sort |
fc receptor‐mediated transcytosis of igg‐coated liposomes across epithelial barriers |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1016/0014-5793(88)80108-x |
| publishDate |
1988 |
| physical |
321-325 |
| description |
<jats:p>Drug carriers such as liposomes are not readily transported across cellular barriers that constitute epithelia. However, certain epithelia (rabbit yolk sac endoderm and enterocytes of suckling rat gut proximal small intestine) are well known to transcytose maternal IgG by Fc receptor‐mediated endocytic events. We have shown that coating liposomes with appropriate IgG enhances their transport across these epithelia, as measured both by radioactivity indicative of liposomal membrane or entrapped <jats:sup>125</jats:sup>I‐PVP and [<jats:sup>3</jats:sup>H]inulin, and by the hypoglycemic effect of entrapped insulin. It is suggested that these transported liposomes follow a pathway of transcytosis in clathrin‐coated vesicles, thus escaping lysosomal degradation.</jats:p> |
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| author | Patel, Harish M., Wild, Arthur E. |
| author_facet | Patel, Harish M., Wild, Arthur E., Patel, Harish M., Wild, Arthur E. |
| author_sort | patel, harish m. |
| container_issue | 2 |
| container_start_page | 321 |
| container_title | FEBS Letters |
| container_volume | 234 |
| description | <jats:p>Drug carriers such as liposomes are not readily transported across cellular barriers that constitute epithelia. However, certain epithelia (rabbit yolk sac endoderm and enterocytes of suckling rat gut proximal small intestine) are well known to transcytose maternal IgG by Fc receptor‐mediated endocytic events. We have shown that coating liposomes with appropriate IgG enhances their transport across these epithelia, as measured both by radioactivity indicative of liposomal membrane or entrapped <jats:sup>125</jats:sup>I‐PVP and [<jats:sup>3</jats:sup>H]inulin, and by the hypoglycemic effect of entrapped insulin. It is suggested that these transported liposomes follow a pathway of transcytosis in clathrin‐coated vesicles, thus escaping lysosomal degradation.</jats:p> |
| doi_str_mv | 10.1016/0014-5793(88)80108-x |
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| imprint | Wiley, 1988 |
| imprint_str_mv | Wiley, 1988 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
| issn | 0014-5793, 1873-3468 |
| issn_str_mv | 0014-5793, 1873-3468 |
| language | English |
| last_indexed | 2024-03-01T14:25:32.896Z |
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| mega_collection | Wiley (CrossRef) |
| physical | 321-325 |
| publishDate | 1988 |
| publishDateSort | 1988 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Patel, Harish M. Wild, Arthur E. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(88)80108-x <jats:p>Drug carriers such as liposomes are not readily transported across cellular barriers that constitute epithelia. However, certain epithelia (rabbit yolk sac endoderm and enterocytes of suckling rat gut proximal small intestine) are well known to transcytose maternal IgG by Fc receptor‐mediated endocytic events. We have shown that coating liposomes with appropriate IgG enhances their transport across these epithelia, as measured both by radioactivity indicative of liposomal membrane or entrapped <jats:sup>125</jats:sup>I‐PVP and [<jats:sup>3</jats:sup>H]inulin, and by the hypoglycemic effect of entrapped insulin. It is suggested that these transported liposomes follow a pathway of transcytosis in clathrin‐coated vesicles, thus escaping lysosomal degradation.</jats:p> Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers FEBS Letters |
| spellingShingle | Patel, Harish M., Wild, Arthur E., FEBS Letters, Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_full | Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_fullStr | Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_full_unstemmed | Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_short | Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| title_sort | fc receptor‐mediated transcytosis of igg‐coated liposomes across epithelial barriers |
| title_unstemmed | Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/0014-5793(88)80108-x |