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Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | FEBS Letters, 228, 1988, 1, S. 118-122 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Gotti, C. Frigerio, F. Bolognesi, M. Longhi, R. Racchetti, G. Clementi, F. Gotti, C. Frigerio, F. Bolognesi, M. Longhi, R. Racchetti, G. Clementi, F. |
|---|---|
| author |
Gotti, C. Frigerio, F. Bolognesi, M. Longhi, R. Racchetti, G. Clementi, F. |
| spellingShingle |
Gotti, C. Frigerio, F. Bolognesi, M. Longhi, R. Racchetti, G. Clementi, F. FEBS Letters Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
gotti, c. |
| spelling |
Gotti, C. Frigerio, F. Bolognesi, M. Longhi, R. Racchetti, G. Clementi, F. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(88)80598-2 <jats:p>A peptide corresponding to amino acid sequence 188–201 of the α‐subunit of <jats:italic>Torpedo</jats:italic> AChR binds α‐Bgtx. The S‐S bridge between Cys 192 and 193 is essential for the binding as Tyr in position 189. The same sequence 188–201 corresponding to human AChR, which instead of Tyr has a Thr in position 189, binds α‐Bgtx with a much lower efficiency. Monoclonal antibodies raised against <jats:italic>Torpedo</jats:italic> peptide 188–201 recognize <jats:italic>Torpedo</jats:italic> AChR and antibodies against <jats:italic>Torpedo</jats:italic> AChR recognize peptide 188–201 indicating that the synthetic peptide and the corresponding sequence in the native molecule share some immunological epitopes. With computer graphics and energy refinement a molecular model of this peptide has been elaborated.</jats:p> Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents FEBS Letters |
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10.1016/0014-5793(88)80598-2 |
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Wiley, 1988 |
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Wiley, 1988 |
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| title |
Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_unstemmed |
Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_full |
Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_fullStr |
Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_full_unstemmed |
Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_short |
Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_sort |
nicotinic acetylcholine receptor: a structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1016/0014-5793(88)80598-2 |
| publishDate |
1988 |
| physical |
118-122 |
| description |
<jats:p>A peptide corresponding to amino acid sequence 188–201 of the α‐subunit of <jats:italic>Torpedo</jats:italic> AChR binds α‐Bgtx. The S‐S bridge between Cys 192 and 193 is essential for the binding as Tyr in position 189. The same sequence 188–201 corresponding to human AChR, which instead of Tyr has a Thr in position 189, binds α‐Bgtx with a much lower efficiency. Monoclonal antibodies raised against <jats:italic>Torpedo</jats:italic> peptide 188–201 recognize <jats:italic>Torpedo</jats:italic> AChR and antibodies against <jats:italic>Torpedo</jats:italic> AChR recognize peptide 188–201 indicating that the synthetic peptide and the corresponding sequence in the native molecule share some immunological epitopes. With computer graphics and energy refinement a molecular model of this peptide has been elaborated.</jats:p> |
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| author | Gotti, C., Frigerio, F., Bolognesi, M., Longhi, R., Racchetti, G., Clementi, F. |
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| description | <jats:p>A peptide corresponding to amino acid sequence 188–201 of the α‐subunit of <jats:italic>Torpedo</jats:italic> AChR binds α‐Bgtx. The S‐S bridge between Cys 192 and 193 is essential for the binding as Tyr in position 189. The same sequence 188–201 corresponding to human AChR, which instead of Tyr has a Thr in position 189, binds α‐Bgtx with a much lower efficiency. Monoclonal antibodies raised against <jats:italic>Torpedo</jats:italic> peptide 188–201 recognize <jats:italic>Torpedo</jats:italic> AChR and antibodies against <jats:italic>Torpedo</jats:italic> AChR recognize peptide 188–201 indicating that the synthetic peptide and the corresponding sequence in the native molecule share some immunological epitopes. With computer graphics and energy refinement a molecular model of this peptide has been elaborated.</jats:p> |
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| imprint | Wiley, 1988 |
| imprint_str_mv | Wiley, 1988 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 118-122 |
| publishDate | 1988 |
| publishDateSort | 1988 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Gotti, C. Frigerio, F. Bolognesi, M. Longhi, R. Racchetti, G. Clementi, F. 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(88)80598-2 <jats:p>A peptide corresponding to amino acid sequence 188–201 of the α‐subunit of <jats:italic>Torpedo</jats:italic> AChR binds α‐Bgtx. The S‐S bridge between Cys 192 and 193 is essential for the binding as Tyr in position 189. The same sequence 188–201 corresponding to human AChR, which instead of Tyr has a Thr in position 189, binds α‐Bgtx with a much lower efficiency. Monoclonal antibodies raised against <jats:italic>Torpedo</jats:italic> peptide 188–201 recognize <jats:italic>Torpedo</jats:italic> AChR and antibodies against <jats:italic>Torpedo</jats:italic> AChR recognize peptide 188–201 indicating that the synthetic peptide and the corresponding sequence in the native molecule share some immunological epitopes. With computer graphics and energy refinement a molecular model of this peptide has been elaborated.</jats:p> Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents FEBS Letters |
| spellingShingle | Gotti, C., Frigerio, F., Bolognesi, M., Longhi, R., Racchetti, G., Clementi, F., FEBS Letters, Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_full | Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_fullStr | Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_full_unstemmed | Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_short | Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_sort | nicotinic acetylcholine receptor: a structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| title_unstemmed | Nicotinic acetylcholine receptor: A structural model for α‐subunit peptide 188–201, the putative binding site for cholinergic agents |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/0014-5793(88)80598-2 |