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Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions
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| Zeitschriftentitel: | FEBS Letters |
|---|---|
| Personen und Körperschaften: | , |
| In: | FEBS Letters, 183, 1985, 2, S. 260-264 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Favaron, Marco Bernardi, Paolo Favaron, Marco Bernardi, Paolo |
|---|---|
| author |
Favaron, Marco Bernardi, Paolo |
| spellingShingle |
Favaron, Marco Bernardi, Paolo FEBS Letters Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| author_sort |
favaron, marco |
| spelling |
Favaron, Marco Bernardi, Paolo 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(85)80789-4 <jats:p>This paper analyzes the kinetics of the Ca<jats:sup>2+</jats:sup> uniporter of mitochondria from rat heart, kidney and liver operating in a range of Ca<jats:sup>2+</jats:sup> concentrations near the steady‐state value (1–4μM). Heart mitochondria exhibit the lowest activity, and physiological Mg<jats:sup>2+</jats:sup> concentrations inhibit the mitochondrial Ca<jats:sup>2+</jats:sup> uniporter by approx. 50% in heart and kidney, and by 20% in liver. At physiological Ca<jats:sup>2+</jats:sup> and Mg<jats:sup>2+</jats:sup> concentrations the external free Ca<jats:sup>2+</jats:sup> maintained by respiring mitochondria in vitro is higher in heart and kidney with respect to liver mitochondria. This behaviour could represent an adaptation of different mitochondria to their specific intracellular environment.</jats:p> Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions FEBS Letters |
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10.1016/0014-5793(85)80789-4 |
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Online Free |
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Wiley, 1985 |
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Wiley, 1985 |
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0014-5793 1873-3468 |
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0014-5793 1873-3468 |
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1985 |
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Wiley |
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FEBS Letters |
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49 |
| title |
Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_unstemmed |
Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_full |
Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_fullStr |
Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_full_unstemmed |
Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_short |
Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_sort |
tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| topic |
Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics |
| url |
http://dx.doi.org/10.1016/0014-5793(85)80789-4 |
| publishDate |
1985 |
| physical |
260-264 |
| description |
<jats:p>This paper analyzes the kinetics of the Ca<jats:sup>2+</jats:sup> uniporter of mitochondria from rat heart, kidney and liver operating in a range of Ca<jats:sup>2+</jats:sup> concentrations near the steady‐state value (1–4μM). Heart mitochondria exhibit the lowest activity, and physiological Mg<jats:sup>2+</jats:sup> concentrations inhibit the mitochondrial Ca<jats:sup>2+</jats:sup> uniporter by approx. 50% in heart and kidney, and by 20% in liver. At physiological Ca<jats:sup>2+</jats:sup> and Mg<jats:sup>2+</jats:sup> concentrations the external free Ca<jats:sup>2+</jats:sup> maintained by respiring mitochondria in vitro is higher in heart and kidney with respect to liver mitochondria. This behaviour could represent an adaptation of different mitochondria to their specific intracellular environment.</jats:p> |
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| author_sort | favaron, marco |
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| container_title | FEBS Letters |
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| description | <jats:p>This paper analyzes the kinetics of the Ca<jats:sup>2+</jats:sup> uniporter of mitochondria from rat heart, kidney and liver operating in a range of Ca<jats:sup>2+</jats:sup> concentrations near the steady‐state value (1–4μM). Heart mitochondria exhibit the lowest activity, and physiological Mg<jats:sup>2+</jats:sup> concentrations inhibit the mitochondrial Ca<jats:sup>2+</jats:sup> uniporter by approx. 50% in heart and kidney, and by 20% in liver. At physiological Ca<jats:sup>2+</jats:sup> and Mg<jats:sup>2+</jats:sup> concentrations the external free Ca<jats:sup>2+</jats:sup> maintained by respiring mitochondria in vitro is higher in heart and kidney with respect to liver mitochondria. This behaviour could represent an adaptation of different mitochondria to their specific intracellular environment.</jats:p> |
| doi_str_mv | 10.1016/0014-5793(85)80789-4 |
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| imprint | Wiley, 1985 |
| imprint_str_mv | Wiley, 1985 |
| institution | DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105 |
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| language | English |
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| physical | 260-264 |
| publishDate | 1985 |
| publishDateSort | 1985 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | FEBS Letters |
| source_id | 49 |
| spelling | Favaron, Marco Bernardi, Paolo 0014-5793 1873-3468 Wiley Cell Biology Genetics Molecular Biology Biochemistry Structural Biology Biophysics http://dx.doi.org/10.1016/0014-5793(85)80789-4 <jats:p>This paper analyzes the kinetics of the Ca<jats:sup>2+</jats:sup> uniporter of mitochondria from rat heart, kidney and liver operating in a range of Ca<jats:sup>2+</jats:sup> concentrations near the steady‐state value (1–4μM). Heart mitochondria exhibit the lowest activity, and physiological Mg<jats:sup>2+</jats:sup> concentrations inhibit the mitochondrial Ca<jats:sup>2+</jats:sup> uniporter by approx. 50% in heart and kidney, and by 20% in liver. At physiological Ca<jats:sup>2+</jats:sup> and Mg<jats:sup>2+</jats:sup> concentrations the external free Ca<jats:sup>2+</jats:sup> maintained by respiring mitochondria in vitro is higher in heart and kidney with respect to liver mitochondria. This behaviour could represent an adaptation of different mitochondria to their specific intracellular environment.</jats:p> Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions FEBS Letters |
| spellingShingle | Favaron, Marco, Bernardi, Paolo, FEBS Letters, Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions, Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| title | Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_full | Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_fullStr | Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_full_unstemmed | Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_short | Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_sort | tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| title_unstemmed | Tissue‐specific modulation of the mitochondrial calcium uniporter by magnesium ions |
| topic | Cell Biology, Genetics, Molecular Biology, Biochemistry, Structural Biology, Biophysics |
| url | http://dx.doi.org/10.1016/0014-5793(85)80789-4 |