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Bioactive phenolic derivatives from Acaena splendens methanol extract
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| Zeitschriftentitel: | Phytotherapy Research |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Phytotherapy Research, 16, 2002, 6, S. 562-566 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Backhouse, N. Delporte, C. Negrete, R. Feliciano, S. A. San López‐Pérez, J. L. Backhouse, N. Delporte, C. Negrete, R. Feliciano, S. A. San López‐Pérez, J. L. |
|---|---|
| author |
Backhouse, N. Delporte, C. Negrete, R. Feliciano, S. A. San López‐Pérez, J. L. |
| spellingShingle |
Backhouse, N. Delporte, C. Negrete, R. Feliciano, S. A. San López‐Pérez, J. L. Phytotherapy Research Bioactive phenolic derivatives from Acaena splendens methanol extract Pharmacology |
| author_sort |
backhouse, n. |
| spelling |
Backhouse, N. Delporte, C. Negrete, R. Feliciano, S. A. San López‐Pérez, J. L. 0951-418X 1099-1573 Wiley Pharmacology http://dx.doi.org/10.1002/ptr.997 <jats:title>Abstract</jats:title><jats:p><jats:italic>Acaena splendens</jats:italic> H. <jats:italic>et</jats:italic> A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the <jats:italic>in vivo</jats:italic> reduction of bacterial pyrogen‐induced fever in rabbits and carrageenan‐induced paw oedema in guinea pigs is presented. The methanol extract named ME‐1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassay‐guided fractionation by column chromatography afforded the active fraction, which contained (‐,‐)‐epicatechin, tiliroside, 7‐O‐acetyl‐3‐O‐β‐<jats:sc>D</jats:sc>‐glucosyl‐kaempferol and 7‐β‐<jats:sc>D</jats:sc>‐glucosyloxy‐5‐hydroxy‐chromone. Copyright © 2002 John Wiley & Sons, Ltd.</jats:p> Bioactive phenolic derivatives from<i> Acaena splendens</i> methanol extract Phytotherapy Research |
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10.1002/ptr.997 |
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Chemie und Pharmazie |
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Phytotherapy Research |
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| title |
Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_unstemmed |
Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_full |
Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_fullStr |
Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_full_unstemmed |
Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_short |
Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_sort |
bioactive phenolic derivatives from<i> acaena splendens</i> methanol extract |
| topic |
Pharmacology |
| url |
http://dx.doi.org/10.1002/ptr.997 |
| publishDate |
2002 |
| physical |
562-566 |
| description |
<jats:title>Abstract</jats:title><jats:p><jats:italic>Acaena splendens</jats:italic> H. <jats:italic>et</jats:italic> A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the <jats:italic>in vivo</jats:italic> reduction of bacterial pyrogen‐induced fever in rabbits and carrageenan‐induced paw oedema in guinea pigs is presented. The methanol extract named ME‐1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassay‐guided fractionation by column chromatography afforded the active fraction, which contained (‐,‐)‐epicatechin, tiliroside, 7‐O‐acetyl‐3‐O‐β‐<jats:sc>D</jats:sc>‐glucosyl‐kaempferol and 7‐β‐<jats:sc>D</jats:sc>‐glucosyloxy‐5‐hydroxy‐chromone. Copyright © 2002 John Wiley & Sons, Ltd.</jats:p> |
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| author | Backhouse, N., Delporte, C., Negrete, R., Feliciano, S. A. San, López‐Pérez, J. L. |
| author_facet | Backhouse, N., Delporte, C., Negrete, R., Feliciano, S. A. San, López‐Pérez, J. L., Backhouse, N., Delporte, C., Negrete, R., Feliciano, S. A. San, López‐Pérez, J. L. |
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| description | <jats:title>Abstract</jats:title><jats:p><jats:italic>Acaena splendens</jats:italic> H. <jats:italic>et</jats:italic> A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the <jats:italic>in vivo</jats:italic> reduction of bacterial pyrogen‐induced fever in rabbits and carrageenan‐induced paw oedema in guinea pigs is presented. The methanol extract named ME‐1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassay‐guided fractionation by column chromatography afforded the active fraction, which contained (‐,‐)‐epicatechin, tiliroside, 7‐O‐acetyl‐3‐O‐β‐<jats:sc>D</jats:sc>‐glucosyl‐kaempferol and 7‐β‐<jats:sc>D</jats:sc>‐glucosyloxy‐5‐hydroxy‐chromone. Copyright © 2002 John Wiley & Sons, Ltd.</jats:p> |
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| imprint | Wiley, 2002 |
| imprint_str_mv | Wiley, 2002 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Backhouse, N. Delporte, C. Negrete, R. Feliciano, S. A. San López‐Pérez, J. L. 0951-418X 1099-1573 Wiley Pharmacology http://dx.doi.org/10.1002/ptr.997 <jats:title>Abstract</jats:title><jats:p><jats:italic>Acaena splendens</jats:italic> H. <jats:italic>et</jats:italic> A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the <jats:italic>in vivo</jats:italic> reduction of bacterial pyrogen‐induced fever in rabbits and carrageenan‐induced paw oedema in guinea pigs is presented. The methanol extract named ME‐1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassay‐guided fractionation by column chromatography afforded the active fraction, which contained (‐,‐)‐epicatechin, tiliroside, 7‐O‐acetyl‐3‐O‐β‐<jats:sc>D</jats:sc>‐glucosyl‐kaempferol and 7‐β‐<jats:sc>D</jats:sc>‐glucosyloxy‐5‐hydroxy‐chromone. Copyright © 2002 John Wiley & Sons, Ltd.</jats:p> Bioactive phenolic derivatives from<i> Acaena splendens</i> methanol extract Phytotherapy Research |
| spellingShingle | Backhouse, N., Delporte, C., Negrete, R., Feliciano, S. A. San, López‐Pérez, J. L., Phytotherapy Research, Bioactive phenolic derivatives from Acaena splendens methanol extract, Pharmacology |
| title | Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_full | Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_fullStr | Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_full_unstemmed | Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_short | Bioactive phenolic derivatives from Acaena splendens methanol extract |
| title_sort | bioactive phenolic derivatives from<i> acaena splendens</i> methanol extract |
| title_unstemmed | Bioactive phenolic derivatives from Acaena splendens methanol extract |
| topic | Pharmacology |
| url | http://dx.doi.org/10.1002/ptr.997 |