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Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase...
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| Zeitschriftentitel: | Phytotherapy Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Phytotherapy Research, 34, 2020, 5, S. 1154-1165 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Xu, Shichen Pan, Jie Cheng, Xian Zheng, Jiangxia Wang, Xiaowen Guan, Haixia Yu, Huixin Bao, Jiandong Zhang, Li Xu, Shichen Pan, Jie Cheng, Xian Zheng, Jiangxia Wang, Xiaowen Guan, Haixia Yu, Huixin Bao, Jiandong Zhang, Li |
|---|---|
| author |
Xu, Shichen Pan, Jie Cheng, Xian Zheng, Jiangxia Wang, Xiaowen Guan, Haixia Yu, Huixin Bao, Jiandong Zhang, Li |
| spellingShingle |
Xu, Shichen Pan, Jie Cheng, Xian Zheng, Jiangxia Wang, Xiaowen Guan, Haixia Yu, Huixin Bao, Jiandong Zhang, Li Phytotherapy Research Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase Pharmacology |
| author_sort |
xu, shichen |
| spelling |
Xu, Shichen Pan, Jie Cheng, Xian Zheng, Jiangxia Wang, Xiaowen Guan, Haixia Yu, Huixin Bao, Jiandong Zhang, Li 0951-418X 1099-1573 Wiley Pharmacology http://dx.doi.org/10.1002/ptr.6586 <jats:p>Diallyl trisulfide (DATS), derived from garlic, is a well‐known hydrogen sulfide (H<jats:sub>2</jats:sub>S) donor. H<jats:sub>2</jats:sub>S has recently emerged as a novel gasotransmitter involved in the regulation of cancer progression. The present study demonstrated that DATS along with other two H<jats:sub>2</jats:sub>S donors, NaHS and GYY4137, significantly inhibited papillary thyroid carcinoma KTC‐1 cells growth. DATS treatment triggered a rapid H<jats:sub>2</jats:sub>S generation within 5 min in KTC‐1 cells. Iodoacetamide, a potent thiol blocker reagent, partially rescued the cell membrane damage and ultimate cell death induced by DATS, indicating H<jats:sub>2</jats:sub>S contributed to the apoptosis‐inducing efficacy of DATS on thyroid cancer cells. Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma‐lyase (CTH), one of H<jats:sub>2</jats:sub>S‐producing enzymes, which was responsible for endogenous H<jats:sub>2</jats:sub>S generation. After DATS treatment, H<jats:sub>2</jats:sub>S quickly permeated cell membranes and activated NF‐κΒ/p65 signaling pathway in KTC‐1 cells. Nuclear translocated NF‐κB bound to the promoter of <jats:italic>CTH</jats:italic> to enhance its transcription. These evidences proved that exogenous H<jats:sub>2</jats:sub>S elevated CTH expression. CTH, in turn, catalytically generated a much higher level of endogenous H<jats:sub>2</jats:sub>S. This positive feedback sustained excess H<jats:sub>2</jats:sub>S production, which resulted in PTC cells growth inhibition. These findings may shed light on the development of novel H<jats:sub>2</jats:sub>S‐based antitumor agents.</jats:p> Diallyl trisulfide, a H<sub>2</sub>S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H<sub>2</sub>S and cystathionine‐gamma‐lyase Phytotherapy Research |
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Wiley, 2020 |
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| title |
Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_unstemmed |
Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_full |
Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_fullStr |
Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_full_unstemmed |
Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_short |
Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_sort |
diallyl trisulfide, a h<sub>2</sub>s donor, inhibits cell growth of human papillary thyroid carcinoma ktc‐1 cells through a positive feedback loop between h<sub>2</sub>s and cystathionine‐gamma‐lyase |
| topic |
Pharmacology |
| url |
http://dx.doi.org/10.1002/ptr.6586 |
| publishDate |
2020 |
| physical |
1154-1165 |
| description |
<jats:p>Diallyl trisulfide (DATS), derived from garlic, is a well‐known hydrogen sulfide (H<jats:sub>2</jats:sub>S) donor. H<jats:sub>2</jats:sub>S has recently emerged as a novel gasotransmitter involved in the regulation of cancer progression. The present study demonstrated that DATS along with other two H<jats:sub>2</jats:sub>S donors, NaHS and GYY4137, significantly inhibited papillary thyroid carcinoma KTC‐1 cells growth. DATS treatment triggered a rapid H<jats:sub>2</jats:sub>S generation within 5 min in KTC‐1 cells. Iodoacetamide, a potent thiol blocker reagent, partially rescued the cell membrane damage and ultimate cell death induced by DATS, indicating H<jats:sub>2</jats:sub>S contributed to the apoptosis‐inducing efficacy of DATS on thyroid cancer cells. Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma‐lyase (CTH), one of H<jats:sub>2</jats:sub>S‐producing enzymes, which was responsible for endogenous H<jats:sub>2</jats:sub>S generation. After DATS treatment, H<jats:sub>2</jats:sub>S quickly permeated cell membranes and activated NF‐κΒ/p65 signaling pathway in KTC‐1 cells. Nuclear translocated NF‐κB bound to the promoter of <jats:italic>CTH</jats:italic> to enhance its transcription. These evidences proved that exogenous H<jats:sub>2</jats:sub>S elevated CTH expression. CTH, in turn, catalytically generated a much higher level of endogenous H<jats:sub>2</jats:sub>S. This positive feedback sustained excess H<jats:sub>2</jats:sub>S production, which resulted in PTC cells growth inhibition. These findings may shed light on the development of novel H<jats:sub>2</jats:sub>S‐based antitumor agents.</jats:p> |
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| author | Xu, Shichen, Pan, Jie, Cheng, Xian, Zheng, Jiangxia, Wang, Xiaowen, Guan, Haixia, Yu, Huixin, Bao, Jiandong, Zhang, Li |
| author_facet | Xu, Shichen, Pan, Jie, Cheng, Xian, Zheng, Jiangxia, Wang, Xiaowen, Guan, Haixia, Yu, Huixin, Bao, Jiandong, Zhang, Li, Xu, Shichen, Pan, Jie, Cheng, Xian, Zheng, Jiangxia, Wang, Xiaowen, Guan, Haixia, Yu, Huixin, Bao, Jiandong, Zhang, Li |
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| description | <jats:p>Diallyl trisulfide (DATS), derived from garlic, is a well‐known hydrogen sulfide (H<jats:sub>2</jats:sub>S) donor. H<jats:sub>2</jats:sub>S has recently emerged as a novel gasotransmitter involved in the regulation of cancer progression. The present study demonstrated that DATS along with other two H<jats:sub>2</jats:sub>S donors, NaHS and GYY4137, significantly inhibited papillary thyroid carcinoma KTC‐1 cells growth. DATS treatment triggered a rapid H<jats:sub>2</jats:sub>S generation within 5 min in KTC‐1 cells. Iodoacetamide, a potent thiol blocker reagent, partially rescued the cell membrane damage and ultimate cell death induced by DATS, indicating H<jats:sub>2</jats:sub>S contributed to the apoptosis‐inducing efficacy of DATS on thyroid cancer cells. Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma‐lyase (CTH), one of H<jats:sub>2</jats:sub>S‐producing enzymes, which was responsible for endogenous H<jats:sub>2</jats:sub>S generation. After DATS treatment, H<jats:sub>2</jats:sub>S quickly permeated cell membranes and activated NF‐κΒ/p65 signaling pathway in KTC‐1 cells. Nuclear translocated NF‐κB bound to the promoter of <jats:italic>CTH</jats:italic> to enhance its transcription. These evidences proved that exogenous H<jats:sub>2</jats:sub>S elevated CTH expression. CTH, in turn, catalytically generated a much higher level of endogenous H<jats:sub>2</jats:sub>S. This positive feedback sustained excess H<jats:sub>2</jats:sub>S production, which resulted in PTC cells growth inhibition. These findings may shed light on the development of novel H<jats:sub>2</jats:sub>S‐based antitumor agents.</jats:p> |
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| imprint | Wiley, 2020 |
| imprint_str_mv | Wiley, 2020 |
| institution | DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275 |
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| spelling | Xu, Shichen Pan, Jie Cheng, Xian Zheng, Jiangxia Wang, Xiaowen Guan, Haixia Yu, Huixin Bao, Jiandong Zhang, Li 0951-418X 1099-1573 Wiley Pharmacology http://dx.doi.org/10.1002/ptr.6586 <jats:p>Diallyl trisulfide (DATS), derived from garlic, is a well‐known hydrogen sulfide (H<jats:sub>2</jats:sub>S) donor. H<jats:sub>2</jats:sub>S has recently emerged as a novel gasotransmitter involved in the regulation of cancer progression. The present study demonstrated that DATS along with other two H<jats:sub>2</jats:sub>S donors, NaHS and GYY4137, significantly inhibited papillary thyroid carcinoma KTC‐1 cells growth. DATS treatment triggered a rapid H<jats:sub>2</jats:sub>S generation within 5 min in KTC‐1 cells. Iodoacetamide, a potent thiol blocker reagent, partially rescued the cell membrane damage and ultimate cell death induced by DATS, indicating H<jats:sub>2</jats:sub>S contributed to the apoptosis‐inducing efficacy of DATS on thyroid cancer cells. Specifically, DATS treatment significantly upregulated the expression and enzymatic activity of cystathionine gamma‐lyase (CTH), one of H<jats:sub>2</jats:sub>S‐producing enzymes, which was responsible for endogenous H<jats:sub>2</jats:sub>S generation. After DATS treatment, H<jats:sub>2</jats:sub>S quickly permeated cell membranes and activated NF‐κΒ/p65 signaling pathway in KTC‐1 cells. Nuclear translocated NF‐κB bound to the promoter of <jats:italic>CTH</jats:italic> to enhance its transcription. These evidences proved that exogenous H<jats:sub>2</jats:sub>S elevated CTH expression. CTH, in turn, catalytically generated a much higher level of endogenous H<jats:sub>2</jats:sub>S. This positive feedback sustained excess H<jats:sub>2</jats:sub>S production, which resulted in PTC cells growth inhibition. These findings may shed light on the development of novel H<jats:sub>2</jats:sub>S‐based antitumor agents.</jats:p> Diallyl trisulfide, a H<sub>2</sub>S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H<sub>2</sub>S and cystathionine‐gamma‐lyase Phytotherapy Research |
| spellingShingle | Xu, Shichen, Pan, Jie, Cheng, Xian, Zheng, Jiangxia, Wang, Xiaowen, Guan, Haixia, Yu, Huixin, Bao, Jiandong, Zhang, Li, Phytotherapy Research, Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase, Pharmacology |
| title | Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_full | Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_fullStr | Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_full_unstemmed | Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_short | Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| title_sort | diallyl trisulfide, a h<sub>2</sub>s donor, inhibits cell growth of human papillary thyroid carcinoma ktc‐1 cells through a positive feedback loop between h<sub>2</sub>s and cystathionine‐gamma‐lyase |
| title_unstemmed | Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC‐1 cells through a positive feedback loop between H2S and cystathionine‐gamma‐lyase |
| topic | Pharmacology |
| url | http://dx.doi.org/10.1002/ptr.6586 |