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Clickable amphiphilic triblock copolymers
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| Zeitschriftentitel: | Journal of Polymer Science Part A: Polymer Chemistry |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Polymer Science Part A: Polymer Chemistry, 50, 2012, 12, S. 2319-2329 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Isaacman, Michael J. Barron, Kathryn A. Theogarajan, Luke S. Isaacman, Michael J. Barron, Kathryn A. Theogarajan, Luke S. |
|---|---|
| author |
Isaacman, Michael J. Barron, Kathryn A. Theogarajan, Luke S. |
| spellingShingle |
Isaacman, Michael J. Barron, Kathryn A. Theogarajan, Luke S. Journal of Polymer Science Part A: Polymer Chemistry Clickable amphiphilic triblock copolymers Materials Chemistry Organic Chemistry Polymers and Plastics |
| author_sort |
isaacman, michael j. |
| spelling |
Isaacman, Michael J. Barron, Kathryn A. Theogarajan, Luke S. 0887-624X 1099-0518 Wiley Materials Chemistry Organic Chemistry Polymers and Plastics http://dx.doi.org/10.1002/pola.25989 <jats:title>Abstract</jats:title><jats:p>Amphiphilic polymers have recently garnered much attention due to their potential use in drug delivery and other biomedical applications. A modular synthesis of these polymers is extremely desirable, because it offers precise individual block characterization and increased yields. We present here for the first time a modular synthesis of poly(oxazoline)–poly(siloxane)–poly(oxazoline) block copolymers that have been clicked together using the copper‐catalyzed azide–alkyne cycloaddition reaction. Various click methodologies for the synthesis of these polymers have been carefully evaluated and optimized. The approach using copper nanoparticles was found to be the most optimal among the methods evaluated. Furthermore, these results were extended to allow for a reactive SiH group‐based siloxane middle block to be successfully clicked. This enables the design of more complex amphiphilic block copolymers that have additional functionality, such as stimuli responsiveness, to be synthesized via a simple hydrosilylation reaction. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012</jats:p> Clickable amphiphilic triblock copolymers Journal of Polymer Science Part A: Polymer Chemistry |
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Journal of Polymer Science Part A: Polymer Chemistry |
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| title |
Clickable amphiphilic triblock copolymers |
| title_unstemmed |
Clickable amphiphilic triblock copolymers |
| title_full |
Clickable amphiphilic triblock copolymers |
| title_fullStr |
Clickable amphiphilic triblock copolymers |
| title_full_unstemmed |
Clickable amphiphilic triblock copolymers |
| title_short |
Clickable amphiphilic triblock copolymers |
| title_sort |
clickable amphiphilic triblock copolymers |
| topic |
Materials Chemistry Organic Chemistry Polymers and Plastics |
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http://dx.doi.org/10.1002/pola.25989 |
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2012 |
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2319-2329 |
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<jats:title>Abstract</jats:title><jats:p>Amphiphilic polymers have recently garnered much attention due to their potential use in drug delivery and other biomedical applications. A modular synthesis of these polymers is extremely desirable, because it offers precise individual block characterization and increased yields. We present here for the first time a modular synthesis of poly(oxazoline)–poly(siloxane)–poly(oxazoline) block copolymers that have been clicked together using the copper‐catalyzed azide–alkyne cycloaddition reaction. Various click methodologies for the synthesis of these polymers have been carefully evaluated and optimized. The approach using copper nanoparticles was found to be the most optimal among the methods evaluated. Furthermore, these results were extended to allow for a reactive SiH group‐based siloxane middle block to be successfully clicked. This enables the design of more complex amphiphilic block copolymers that have additional functionality, such as stimuli responsiveness, to be synthesized via a simple hydrosilylation reaction. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012</jats:p> |
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| author | Isaacman, Michael J., Barron, Kathryn A., Theogarajan, Luke S. |
| author_facet | Isaacman, Michael J., Barron, Kathryn A., Theogarajan, Luke S., Isaacman, Michael J., Barron, Kathryn A., Theogarajan, Luke S. |
| author_sort | isaacman, michael j. |
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| container_title | Journal of Polymer Science Part A: Polymer Chemistry |
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| description | <jats:title>Abstract</jats:title><jats:p>Amphiphilic polymers have recently garnered much attention due to their potential use in drug delivery and other biomedical applications. A modular synthesis of these polymers is extremely desirable, because it offers precise individual block characterization and increased yields. We present here for the first time a modular synthesis of poly(oxazoline)–poly(siloxane)–poly(oxazoline) block copolymers that have been clicked together using the copper‐catalyzed azide–alkyne cycloaddition reaction. Various click methodologies for the synthesis of these polymers have been carefully evaluated and optimized. The approach using copper nanoparticles was found to be the most optimal among the methods evaluated. Furthermore, these results were extended to allow for a reactive SiH group‐based siloxane middle block to be successfully clicked. This enables the design of more complex amphiphilic block copolymers that have additional functionality, such as stimuli responsiveness, to be synthesized via a simple hydrosilylation reaction. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012</jats:p> |
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| series | Journal of Polymer Science Part A: Polymer Chemistry |
| source_id | 49 |
| spelling | Isaacman, Michael J. Barron, Kathryn A. Theogarajan, Luke S. 0887-624X 1099-0518 Wiley Materials Chemistry Organic Chemistry Polymers and Plastics http://dx.doi.org/10.1002/pola.25989 <jats:title>Abstract</jats:title><jats:p>Amphiphilic polymers have recently garnered much attention due to their potential use in drug delivery and other biomedical applications. A modular synthesis of these polymers is extremely desirable, because it offers precise individual block characterization and increased yields. We present here for the first time a modular synthesis of poly(oxazoline)–poly(siloxane)–poly(oxazoline) block copolymers that have been clicked together using the copper‐catalyzed azide–alkyne cycloaddition reaction. Various click methodologies for the synthesis of these polymers have been carefully evaluated and optimized. The approach using copper nanoparticles was found to be the most optimal among the methods evaluated. Furthermore, these results were extended to allow for a reactive SiH group‐based siloxane middle block to be successfully clicked. This enables the design of more complex amphiphilic block copolymers that have additional functionality, such as stimuli responsiveness, to be synthesized via a simple hydrosilylation reaction. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012</jats:p> Clickable amphiphilic triblock copolymers Journal of Polymer Science Part A: Polymer Chemistry |
| spellingShingle | Isaacman, Michael J., Barron, Kathryn A., Theogarajan, Luke S., Journal of Polymer Science Part A: Polymer Chemistry, Clickable amphiphilic triblock copolymers, Materials Chemistry, Organic Chemistry, Polymers and Plastics |
| title | Clickable amphiphilic triblock copolymers |
| title_full | Clickable amphiphilic triblock copolymers |
| title_fullStr | Clickable amphiphilic triblock copolymers |
| title_full_unstemmed | Clickable amphiphilic triblock copolymers |
| title_short | Clickable amphiphilic triblock copolymers |
| title_sort | clickable amphiphilic triblock copolymers |
| title_unstemmed | Clickable amphiphilic triblock copolymers |
| topic | Materials Chemistry, Organic Chemistry, Polymers and Plastics |
| url | http://dx.doi.org/10.1002/pola.25989 |