Eintrag weiter verarbeiten
Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate)
Gespeichert in:
| Zeitschriftentitel: | Journal of Polymer Science: Polymer Chemistry Edition |
|---|---|
| Personen und Körperschaften: | , , |
| In: | Journal of Polymer Science: Polymer Chemistry Edition, 16, 1978, 8, S. 2001-2017 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Sakamoto, Munenori Kuroyanagi, Yoshimitsu Sakamoto, Ryuichi Sakamoto, Munenori Kuroyanagi, Yoshimitsu Sakamoto, Ryuichi |
|---|---|
| author |
Sakamoto, Munenori Kuroyanagi, Yoshimitsu Sakamoto, Ryuichi |
| spellingShingle |
Sakamoto, Munenori Kuroyanagi, Yoshimitsu Sakamoto, Ryuichi Journal of Polymer Science: Polymer Chemistry Edition Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) General Medicine |
| author_sort |
sakamoto, munenori |
| spelling |
Sakamoto, Munenori Kuroyanagi, Yoshimitsu Sakamoto, Ryuichi 0360-6376 1542-9369 Wiley General Medicine http://dx.doi.org/10.1002/pol.1978.170160817 <jats:title>Abstract</jats:title><jats:p>A number of multi‐<jats:italic>N</jats:italic><jats:sup>ϵ</jats:sup>‐poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamyl)copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s with branches having various degrees of polymerization and with various intervals of the grafting sites in the core molecule were prepared in <jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>‐dimethylformamide containing dimethyl sulfoxide by the reaction of <jats:italic>N</jats:italic>‐carboxy anhydride of γ‐benzyl <jats:sc>L</jats:sc>‐glutamate with random copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s of different composition with various anhydride‐initiator ratios. The relationship between the intrinsic viscosity measured in a coil solvent, dichloroacetic acid (DCA), and the number‐average molecular weight determined by osmometry was found to be expressed by the Mark–Houwink–Sakurada equation for the multichain copoly(α‐amino acid)s which were made from the same polymeric initiator. The observed α values of the multichain copoly(α‐amino acid)s in the equation were lower than that of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate). The solvent induced helix–coil transition of the multichain copolymer was investigated in the chloroform‒DCA system by the ORD technique. Two kinds of transition regions were clearly distinguished: The α‐helices of the core molecules underwent the transition at lower DCA concentration and those of the branch chains at higher DCA concentration. The reduced viscosity of the multichain copoly‐(α‐amino acid) increased slightly between the two transition regions, in contrast to the large decrease in the reduced viscosity of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate) during the helix–coil transition.</jats:p> Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐<i>N</i><sup>ϵ</sup>‐poly(γ‐benzyl‐<scp>L</scp>‐glutamyl)copoly(<scp>L</scp>‐lysine γ‐methyl‐<scp>L</scp>‐glutamate) Journal of Polymer Science: Polymer Chemistry Edition |
| doi_str_mv |
10.1002/pol.1978.170160817 |
| facet_avail |
Online |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9wb2wuMTk3OC4xNzAxNjA4MTc |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9wb2wuMTk3OC4xNzAxNjA4MTc |
| institution |
DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 |
| imprint |
Wiley, 1978 |
| imprint_str_mv |
Wiley, 1978 |
| issn |
0360-6376 1542-9369 |
| issn_str_mv |
0360-6376 1542-9369 |
| language |
English |
| mega_collection |
Wiley (CrossRef) |
| match_str |
sakamoto1978multichaincopolyaaminoacidiipreparationandpropertiesofmultinpolygbenzyllglutamylcopolyllysinegmethyllglutamate |
| publishDateSort |
1978 |
| publisher |
Wiley |
| recordtype |
ai |
| record_format |
ai |
| series |
Journal of Polymer Science: Polymer Chemistry Edition |
| source_id |
49 |
| title |
Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_unstemmed |
Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_full |
Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_fullStr |
Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_full_unstemmed |
Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_short |
Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_sort |
multichain copoly(α‐amino acid). ii. preparation and properties of multi‐<i>n</i><sup>ϵ</sup>‐poly(γ‐benzyl‐<scp>l</scp>‐glutamyl)copoly(<scp>l</scp>‐lysine γ‐methyl‐<scp>l</scp>‐glutamate) |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1002/pol.1978.170160817 |
| publishDate |
1978 |
| physical |
2001-2017 |
| description |
<jats:title>Abstract</jats:title><jats:p>A number of multi‐<jats:italic>N</jats:italic><jats:sup>ϵ</jats:sup>‐poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamyl)copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s with branches having various degrees of polymerization and with various intervals of the grafting sites in the core molecule were prepared in <jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>‐dimethylformamide containing dimethyl sulfoxide by the reaction of <jats:italic>N</jats:italic>‐carboxy anhydride of γ‐benzyl <jats:sc>L</jats:sc>‐glutamate with random copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s of different composition with various anhydride‐initiator ratios. The relationship between the intrinsic viscosity measured in a coil solvent, dichloroacetic acid (DCA), and the number‐average molecular weight determined by osmometry was found to be expressed by the Mark–Houwink–Sakurada equation for the multichain copoly(α‐amino acid)s which were made from the same polymeric initiator. The observed α values of the multichain copoly(α‐amino acid)s in the equation were lower than that of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate). The solvent induced helix–coil transition of the multichain copolymer was investigated in the chloroform‒DCA system by the ORD technique. Two kinds of transition regions were clearly distinguished: The α‐helices of the core molecules underwent the transition at lower DCA concentration and those of the branch chains at higher DCA concentration. The reduced viscosity of the multichain copoly‐(α‐amino acid) increased slightly between the two transition regions, in contrast to the large decrease in the reduced viscosity of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate) during the helix–coil transition.</jats:p> |
| container_issue |
8 |
| container_start_page |
2001 |
| container_title |
Journal of Polymer Science: Polymer Chemistry Edition |
| container_volume |
16 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792336427587993606 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T15:00:15.694Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Multichain+copoly%28%CE%B1%E2%80%90amino+acid%29.+II.+Preparation+and+properties+of+multi%E2%80%90N%CF%B5%E2%80%90poly%28%CE%B3%E2%80%90benzyl%E2%80%90L%E2%80%90glutamyl%29copoly%28L%E2%80%90lysine+%CE%B3%E2%80%90methyl%E2%80%90L%E2%80%90glutamate%29&rft.date=1978-08-01&genre=article&issn=1542-9369&volume=16&issue=8&spage=2001&epage=2017&pages=2001-2017&jtitle=Journal+of+Polymer+Science%3A+Polymer+Chemistry+Edition&atitle=Multichain+copoly%28%CE%B1%E2%80%90amino+acid%29.+II.+Preparation+and+properties+of+multi%E2%80%90%3Ci%3EN%3C%2Fi%3E%3Csup%3E%CF%B5%3C%2Fsup%3E%E2%80%90poly%28%CE%B3%E2%80%90benzyl%E2%80%90%3Cscp%3EL%3C%2Fscp%3E%E2%80%90glutamyl%29copoly%28%3Cscp%3EL%3C%2Fscp%3E%E2%80%90lysine+%CE%B3%E2%80%90methyl%E2%80%90%3Cscp%3EL%3C%2Fscp%3E%E2%80%90glutamate%29&aulast=Sakamoto&aufirst=Ryuichi&rft_id=info%3Adoi%2F10.1002%2Fpol.1978.170160817&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792336427587993606 |
| author | Sakamoto, Munenori, Kuroyanagi, Yoshimitsu, Sakamoto, Ryuichi |
| author_facet | Sakamoto, Munenori, Kuroyanagi, Yoshimitsu, Sakamoto, Ryuichi, Sakamoto, Munenori, Kuroyanagi, Yoshimitsu, Sakamoto, Ryuichi |
| author_sort | sakamoto, munenori |
| container_issue | 8 |
| container_start_page | 2001 |
| container_title | Journal of Polymer Science: Polymer Chemistry Edition |
| container_volume | 16 |
| description | <jats:title>Abstract</jats:title><jats:p>A number of multi‐<jats:italic>N</jats:italic><jats:sup>ϵ</jats:sup>‐poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamyl)copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s with branches having various degrees of polymerization and with various intervals of the grafting sites in the core molecule were prepared in <jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>‐dimethylformamide containing dimethyl sulfoxide by the reaction of <jats:italic>N</jats:italic>‐carboxy anhydride of γ‐benzyl <jats:sc>L</jats:sc>‐glutamate with random copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s of different composition with various anhydride‐initiator ratios. The relationship between the intrinsic viscosity measured in a coil solvent, dichloroacetic acid (DCA), and the number‐average molecular weight determined by osmometry was found to be expressed by the Mark–Houwink–Sakurada equation for the multichain copoly(α‐amino acid)s which were made from the same polymeric initiator. The observed α values of the multichain copoly(α‐amino acid)s in the equation were lower than that of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate). The solvent induced helix–coil transition of the multichain copolymer was investigated in the chloroform‒DCA system by the ORD technique. Two kinds of transition regions were clearly distinguished: The α‐helices of the core molecules underwent the transition at lower DCA concentration and those of the branch chains at higher DCA concentration. The reduced viscosity of the multichain copoly‐(α‐amino acid) increased slightly between the two transition regions, in contrast to the large decrease in the reduced viscosity of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate) during the helix–coil transition.</jats:p> |
| doi_str_mv | 10.1002/pol.1978.170160817 |
| facet_avail | Online |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9wb2wuMTk3OC4xNzAxNjA4MTc |
| imprint | Wiley, 1978 |
| imprint_str_mv | Wiley, 1978 |
| institution | DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1 |
| issn | 0360-6376, 1542-9369 |
| issn_str_mv | 0360-6376, 1542-9369 |
| language | English |
| last_indexed | 2024-03-01T15:00:15.694Z |
| match_str | sakamoto1978multichaincopolyaaminoacidiipreparationandpropertiesofmultinpolygbenzyllglutamylcopolyllysinegmethyllglutamate |
| mega_collection | Wiley (CrossRef) |
| physical | 2001-2017 |
| publishDate | 1978 |
| publishDateSort | 1978 |
| publisher | Wiley |
| record_format | ai |
| recordtype | ai |
| series | Journal of Polymer Science: Polymer Chemistry Edition |
| source_id | 49 |
| spelling | Sakamoto, Munenori Kuroyanagi, Yoshimitsu Sakamoto, Ryuichi 0360-6376 1542-9369 Wiley General Medicine http://dx.doi.org/10.1002/pol.1978.170160817 <jats:title>Abstract</jats:title><jats:p>A number of multi‐<jats:italic>N</jats:italic><jats:sup>ϵ</jats:sup>‐poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamyl)copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s with branches having various degrees of polymerization and with various intervals of the grafting sites in the core molecule were prepared in <jats:italic>N</jats:italic>,<jats:italic>N</jats:italic>‐dimethylformamide containing dimethyl sulfoxide by the reaction of <jats:italic>N</jats:italic>‐carboxy anhydride of γ‐benzyl <jats:sc>L</jats:sc>‐glutamate with random copoly(<jats:sc>L</jats:sc>‐lysine γ‐methyl‐<jats:sc>L</jats:sc>‐glutamate)s of different composition with various anhydride‐initiator ratios. The relationship between the intrinsic viscosity measured in a coil solvent, dichloroacetic acid (DCA), and the number‐average molecular weight determined by osmometry was found to be expressed by the Mark–Houwink–Sakurada equation for the multichain copoly(α‐amino acid)s which were made from the same polymeric initiator. The observed α values of the multichain copoly(α‐amino acid)s in the equation were lower than that of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate). The solvent induced helix–coil transition of the multichain copolymer was investigated in the chloroform‒DCA system by the ORD technique. Two kinds of transition regions were clearly distinguished: The α‐helices of the core molecules underwent the transition at lower DCA concentration and those of the branch chains at higher DCA concentration. The reduced viscosity of the multichain copoly‐(α‐amino acid) increased slightly between the two transition regions, in contrast to the large decrease in the reduced viscosity of linear poly(γ‐benzyl‐<jats:sc>L</jats:sc>‐glutamate) during the helix–coil transition.</jats:p> Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐<i>N</i><sup>ϵ</sup>‐poly(γ‐benzyl‐<scp>L</scp>‐glutamyl)copoly(<scp>L</scp>‐lysine γ‐methyl‐<scp>L</scp>‐glutamate) Journal of Polymer Science: Polymer Chemistry Edition |
| spellingShingle | Sakamoto, Munenori, Kuroyanagi, Yoshimitsu, Sakamoto, Ryuichi, Journal of Polymer Science: Polymer Chemistry Edition, Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate), General Medicine |
| title | Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_full | Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_fullStr | Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_full_unstemmed | Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_short | Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| title_sort | multichain copoly(α‐amino acid). ii. preparation and properties of multi‐<i>n</i><sup>ϵ</sup>‐poly(γ‐benzyl‐<scp>l</scp>‐glutamyl)copoly(<scp>l</scp>‐lysine γ‐methyl‐<scp>l</scp>‐glutamate) |
| title_unstemmed | Multichain copoly(α‐amino acid). II. Preparation and properties of multi‐Nϵ‐poly(γ‐benzyl‐L‐glutamyl)copoly(L‐lysine γ‐methyl‐L‐glutamate) |
| topic | General Medicine |
| url | http://dx.doi.org/10.1002/pol.1978.170160817 |