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Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers
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| Zeitschriftentitel: | Prenatal Diagnosis |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Prenatal Diagnosis, 32, 2012, 11, S. 1071-1076 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Spaggiari, Emmanuel Heidet, Laurence Grange, Gilles Guimiot, Fabien Dreux, Sophie Delezoide, Anne‐Lise Muller, Françoise Spaggiari, Emmanuel Heidet, Laurence Grange, Gilles Guimiot, Fabien Dreux, Sophie Delezoide, Anne‐Lise Muller, Françoise |
|---|---|
| author |
Spaggiari, Emmanuel Heidet, Laurence Grange, Gilles Guimiot, Fabien Dreux, Sophie Delezoide, Anne‐Lise Muller, Françoise |
| spellingShingle |
Spaggiari, Emmanuel Heidet, Laurence Grange, Gilles Guimiot, Fabien Dreux, Sophie Delezoide, Anne‐Lise Muller, Françoise Prenatal Diagnosis Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers Genetics (clinical) Obstetrics and Gynecology |
| author_sort |
spaggiari, emmanuel |
| spelling |
Spaggiari, Emmanuel Heidet, Laurence Grange, Gilles Guimiot, Fabien Dreux, Sophie Delezoide, Anne‐Lise Muller, Françoise 0197-3851 1097-0223 Wiley Genetics (clinical) Obstetrics and Gynecology http://dx.doi.org/10.1002/pd.3960 <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study pregnancy outcomes and fetal renal prognosis markers in cases of exposure to renin–angiotensin system blockers.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a retrospective study of a series of 21 patients exposed to blockers of the renin–angiotensin system during pregnancy. Two markers were prenatally studied, fetal serum β2‐microglobulin and amniotic fluid volume. Poor renal prognosis evaluation was based on postnatal glomerular filtration rate or on the presence of renal histologic lesions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal β2‐microglobulin). All fetuses with persistent oligohydramnios or β2‐microglobulin ≥5 mg/L presented an adverse renal outcome.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Exposure to renin–angiotensin system blockers complicated by oligohydramnios is associated with a very poor outcome. We propose a prenatal management based on amniotic fluid volume monitoring and fetal serum β2‐microglobulin. However, our preliminary results have to be confirmed by a larger study. © 2012 John Wiley & Sons, Ltd.</jats:p></jats:sec> Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers Prenatal Diagnosis |
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Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_unstemmed |
Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_full |
Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_fullStr |
Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
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Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_short |
Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_sort |
prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| topic |
Genetics (clinical) Obstetrics and Gynecology |
| url |
http://dx.doi.org/10.1002/pd.3960 |
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2012 |
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1071-1076 |
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<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study pregnancy outcomes and fetal renal prognosis markers in cases of exposure to renin–angiotensin system blockers.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a retrospective study of a series of 21 patients exposed to blockers of the renin–angiotensin system during pregnancy. Two markers were prenatally studied, fetal serum β2‐microglobulin and amniotic fluid volume. Poor renal prognosis evaluation was based on postnatal glomerular filtration rate or on the presence of renal histologic lesions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal β2‐microglobulin). All fetuses with persistent oligohydramnios or β2‐microglobulin ≥5 mg/L presented an adverse renal outcome.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Exposure to renin–angiotensin system blockers complicated by oligohydramnios is associated with a very poor outcome. We propose a prenatal management based on amniotic fluid volume monitoring and fetal serum β2‐microglobulin. However, our preliminary results have to be confirmed by a larger study. © 2012 John Wiley & Sons, Ltd.</jats:p></jats:sec> |
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| author | Spaggiari, Emmanuel, Heidet, Laurence, Grange, Gilles, Guimiot, Fabien, Dreux, Sophie, Delezoide, Anne‐Lise, Muller, Françoise |
| author_facet | Spaggiari, Emmanuel, Heidet, Laurence, Grange, Gilles, Guimiot, Fabien, Dreux, Sophie, Delezoide, Anne‐Lise, Muller, Françoise, Spaggiari, Emmanuel, Heidet, Laurence, Grange, Gilles, Guimiot, Fabien, Dreux, Sophie, Delezoide, Anne‐Lise, Muller, Françoise |
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| description | <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study pregnancy outcomes and fetal renal prognosis markers in cases of exposure to renin–angiotensin system blockers.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a retrospective study of a series of 21 patients exposed to blockers of the renin–angiotensin system during pregnancy. Two markers were prenatally studied, fetal serum β2‐microglobulin and amniotic fluid volume. Poor renal prognosis evaluation was based on postnatal glomerular filtration rate or on the presence of renal histologic lesions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal β2‐microglobulin). All fetuses with persistent oligohydramnios or β2‐microglobulin ≥5 mg/L presented an adverse renal outcome.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Exposure to renin–angiotensin system blockers complicated by oligohydramnios is associated with a very poor outcome. We propose a prenatal management based on amniotic fluid volume monitoring and fetal serum β2‐microglobulin. However, our preliminary results have to be confirmed by a larger study. © 2012 John Wiley & Sons, Ltd.</jats:p></jats:sec> |
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| spelling | Spaggiari, Emmanuel Heidet, Laurence Grange, Gilles Guimiot, Fabien Dreux, Sophie Delezoide, Anne‐Lise Muller, Françoise 0197-3851 1097-0223 Wiley Genetics (clinical) Obstetrics and Gynecology http://dx.doi.org/10.1002/pd.3960 <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To study pregnancy outcomes and fetal renal prognosis markers in cases of exposure to renin–angiotensin system blockers.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a retrospective study of a series of 21 patients exposed to blockers of the renin–angiotensin system during pregnancy. Two markers were prenatally studied, fetal serum β2‐microglobulin and amniotic fluid volume. Poor renal prognosis evaluation was based on postnatal glomerular filtration rate or on the presence of renal histologic lesions.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of the 21 fetuses, only one had a normal postnatal renal function at birth (oligohydramnios regression and normal β2‐microglobulin). All fetuses with persistent oligohydramnios or β2‐microglobulin ≥5 mg/L presented an adverse renal outcome.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Exposure to renin–angiotensin system blockers complicated by oligohydramnios is associated with a very poor outcome. We propose a prenatal management based on amniotic fluid volume monitoring and fetal serum β2‐microglobulin. However, our preliminary results have to be confirmed by a larger study. © 2012 John Wiley & Sons, Ltd.</jats:p></jats:sec> Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers Prenatal Diagnosis |
| spellingShingle | Spaggiari, Emmanuel, Heidet, Laurence, Grange, Gilles, Guimiot, Fabien, Dreux, Sophie, Delezoide, Anne‐Lise, Muller, Françoise, Prenatal Diagnosis, Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers, Genetics (clinical), Obstetrics and Gynecology |
| title | Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_full | Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_fullStr | Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_full_unstemmed | Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_short | Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_sort | prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| title_unstemmed | Prognosis and outcome of pregnancies exposed to renin–angiotensin system blockers |
| topic | Genetics (clinical), Obstetrics and Gynecology |
| url | http://dx.doi.org/10.1002/pd.3960 |