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Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas
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| Zeitschriftentitel: | The Journal of Pathology |
|---|---|
| Personen und Körperschaften: | , , |
| In: | The Journal of Pathology, 223, 2011, 1, S. 46-53 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Chen, Ying Yusenko, Maria V Kovacs, Gyula Chen, Ying Yusenko, Maria V Kovacs, Gyula |
|---|---|
| author |
Chen, Ying Yusenko, Maria V Kovacs, Gyula |
| spellingShingle |
Chen, Ying Yusenko, Maria V Kovacs, Gyula The Journal of Pathology Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas Pathology and Forensic Medicine |
| author_sort |
chen, ying |
| spelling |
Chen, Ying Yusenko, Maria V Kovacs, Gyula 0022-3417 1096-9896 Wiley Pathology and Forensic Medicine http://dx.doi.org/10.1002/path.2764 <jats:title>Abstract</jats:title><jats:p>The mortality of patients with conventional renal cell carcinomas (RCC) correlates directly with the development of metastasis, which cannot be reliably predicted simply by TNM classification. The aim of this study was to identify genes associated with the tumour progression. We have analysed the global gene expression in conventional RCCs, including those with and without progression by Affymetrix GeneChip and selected the genes by gene set enrichment analysis. The expression and function of <jats:italic>KISS1R</jats:italic> was validated by RT–PCR, western blotting and immunohistochemistry and by <jats:italic>in vitro</jats:italic> experiments. An immunohistochemical and clinical follow‐up study showed that lack of <jats:italic>KISS1R</jats:italic> expression is associated with rapid progression of tumours. <jats:italic>In vitro</jats:italic> studies showed that activation of <jats:italic>KISS1/KISS1R</jats:italic> signalling by kisspeptin treatment decreases the motility and invasive capacity of tumour cells. The kisspeptin treatment also induces the expression of <jats:italic>KISS1R</jats:italic> in tumour cells <jats:italic>in vitro</jats:italic> and activates signalling in cases without constitutional expression of the receptor. Expression of the KISS1R protein can be used for estimating the prognosis of conventional RCCs. Confirming the activation of <jats:italic>KISS1R</jats:italic> signalling <jats:italic>in vivo</jats:italic> may open a way for kisspeptin treatment of patients with conventional RCCs. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</jats:p> Lack of <i>KISS1R</i> expression is associated with rapid progression of conventional renal cell carcinomas The Journal of Pathology |
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| title |
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_unstemmed |
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_full |
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_fullStr |
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_full_unstemmed |
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_short |
Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_sort |
lack of <i>kiss1r</i> expression is associated with rapid progression of conventional renal cell carcinomas |
| topic |
Pathology and Forensic Medicine |
| url |
http://dx.doi.org/10.1002/path.2764 |
| publishDate |
2011 |
| physical |
46-53 |
| description |
<jats:title>Abstract</jats:title><jats:p>The mortality of patients with conventional renal cell carcinomas (RCC) correlates directly with the development of metastasis, which cannot be reliably predicted simply by TNM classification. The aim of this study was to identify genes associated with the tumour progression. We have analysed the global gene expression in conventional RCCs, including those with and without progression by Affymetrix GeneChip and selected the genes by gene set enrichment analysis. The expression and function of <jats:italic>KISS1R</jats:italic> was validated by RT–PCR, western blotting and immunohistochemistry and by <jats:italic>in vitro</jats:italic> experiments. An immunohistochemical and clinical follow‐up study showed that lack of <jats:italic>KISS1R</jats:italic> expression is associated with rapid progression of tumours. <jats:italic>In vitro</jats:italic> studies showed that activation of <jats:italic>KISS1/KISS1R</jats:italic> signalling by kisspeptin treatment decreases the motility and invasive capacity of tumour cells. The kisspeptin treatment also induces the expression of <jats:italic>KISS1R</jats:italic> in tumour cells <jats:italic>in vitro</jats:italic> and activates signalling in cases without constitutional expression of the receptor. Expression of the KISS1R protein can be used for estimating the prognosis of conventional RCCs. Confirming the activation of <jats:italic>KISS1R</jats:italic> signalling <jats:italic>in vivo</jats:italic> may open a way for kisspeptin treatment of patients with conventional RCCs. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</jats:p> |
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| author | Chen, Ying, Yusenko, Maria V, Kovacs, Gyula |
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| description | <jats:title>Abstract</jats:title><jats:p>The mortality of patients with conventional renal cell carcinomas (RCC) correlates directly with the development of metastasis, which cannot be reliably predicted simply by TNM classification. The aim of this study was to identify genes associated with the tumour progression. We have analysed the global gene expression in conventional RCCs, including those with and without progression by Affymetrix GeneChip and selected the genes by gene set enrichment analysis. The expression and function of <jats:italic>KISS1R</jats:italic> was validated by RT–PCR, western blotting and immunohistochemistry and by <jats:italic>in vitro</jats:italic> experiments. An immunohistochemical and clinical follow‐up study showed that lack of <jats:italic>KISS1R</jats:italic> expression is associated with rapid progression of tumours. <jats:italic>In vitro</jats:italic> studies showed that activation of <jats:italic>KISS1/KISS1R</jats:italic> signalling by kisspeptin treatment decreases the motility and invasive capacity of tumour cells. The kisspeptin treatment also induces the expression of <jats:italic>KISS1R</jats:italic> in tumour cells <jats:italic>in vitro</jats:italic> and activates signalling in cases without constitutional expression of the receptor. Expression of the KISS1R protein can be used for estimating the prognosis of conventional RCCs. Confirming the activation of <jats:italic>KISS1R</jats:italic> signalling <jats:italic>in vivo</jats:italic> may open a way for kisspeptin treatment of patients with conventional RCCs. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</jats:p> |
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| spelling | Chen, Ying Yusenko, Maria V Kovacs, Gyula 0022-3417 1096-9896 Wiley Pathology and Forensic Medicine http://dx.doi.org/10.1002/path.2764 <jats:title>Abstract</jats:title><jats:p>The mortality of patients with conventional renal cell carcinomas (RCC) correlates directly with the development of metastasis, which cannot be reliably predicted simply by TNM classification. The aim of this study was to identify genes associated with the tumour progression. We have analysed the global gene expression in conventional RCCs, including those with and without progression by Affymetrix GeneChip and selected the genes by gene set enrichment analysis. The expression and function of <jats:italic>KISS1R</jats:italic> was validated by RT–PCR, western blotting and immunohistochemistry and by <jats:italic>in vitro</jats:italic> experiments. An immunohistochemical and clinical follow‐up study showed that lack of <jats:italic>KISS1R</jats:italic> expression is associated with rapid progression of tumours. <jats:italic>In vitro</jats:italic> studies showed that activation of <jats:italic>KISS1/KISS1R</jats:italic> signalling by kisspeptin treatment decreases the motility and invasive capacity of tumour cells. The kisspeptin treatment also induces the expression of <jats:italic>KISS1R</jats:italic> in tumour cells <jats:italic>in vitro</jats:italic> and activates signalling in cases without constitutional expression of the receptor. Expression of the KISS1R protein can be used for estimating the prognosis of conventional RCCs. Confirming the activation of <jats:italic>KISS1R</jats:italic> signalling <jats:italic>in vivo</jats:italic> may open a way for kisspeptin treatment of patients with conventional RCCs. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</jats:p> Lack of <i>KISS1R</i> expression is associated with rapid progression of conventional renal cell carcinomas The Journal of Pathology |
| spellingShingle | Chen, Ying, Yusenko, Maria V, Kovacs, Gyula, The Journal of Pathology, Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas, Pathology and Forensic Medicine |
| title | Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_full | Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_fullStr | Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_full_unstemmed | Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_short | Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| title_sort | lack of <i>kiss1r</i> expression is associated with rapid progression of conventional renal cell carcinomas |
| title_unstemmed | Lack of KISS1R expression is associated with rapid progression of conventional renal cell carcinomas |
| topic | Pathology and Forensic Medicine |
| url | http://dx.doi.org/10.1002/path.2764 |