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Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis
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| Zeitschriftentitel: | Phytochemical Analysis |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Phytochemical Analysis, 31, 2020, 2, S. 164-182 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Li, Xuejiao Wang, Ying Sun, Jiachen Li, Xia Zhao, Chengcheng Zhao, Ping Man, Shuli Gao, Wenyuan Li, Xuejiao Wang, Ying Sun, Jiachen Li, Xia Zhao, Chengcheng Zhao, Ping Man, Shuli Gao, Wenyuan |
|---|---|
| author |
Li, Xuejiao Wang, Ying Sun, Jiachen Li, Xia Zhao, Chengcheng Zhao, Ping Man, Shuli Gao, Wenyuan |
| spellingShingle |
Li, Xuejiao Wang, Ying Sun, Jiachen Li, Xia Zhao, Chengcheng Zhao, Ping Man, Shuli Gao, Wenyuan Phytochemical Analysis Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis Complementary and alternative medicine Drug Discovery Plant Science Molecular Medicine General Medicine Biochemistry Food Science Analytical Chemistry |
| author_sort |
li, xuejiao |
| spelling |
Li, Xuejiao Wang, Ying Sun, Jiachen Li, Xia Zhao, Chengcheng Zhao, Ping Man, Shuli Gao, Wenyuan 0958-0344 1099-1565 Wiley Complementary and alternative medicine Drug Discovery Plant Science Molecular Medicine General Medicine Biochemistry Food Science Analytical Chemistry http://dx.doi.org/10.1002/pca.2876 <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p><jats:italic>Dioscorea</jats:italic> species, which contain abundant steroidal saponins, have been used as folk medicines or raw materials to synthesise steroid drugs.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To establish a rapid chemotaxonomic method that will comprehensively resolve confusions about genetic relationships of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A comprehensive strategy using ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (UHPLC‐QTOF‐MS/MS) was firstly proposed to evaluate the chemotaxonomy of 12 species (27 taxa) from China by hierarchical cluster analysis (HCA) based on the variations of the identified metabolites.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twenty‐eight secondary metabolites (mainly steroidal saponins) were identified. The MS<jats:sup><jats:italic>n</jats:italic></jats:sup> fragmentation patterns of DA (a new acetylated steroidal saponin at C‐7 position) were firstly reported. Moreover, eight major steroidal saponins were further quantified simultaneously by UPLC‐QTOF‐MS method. According to HCA results, <jats:styled-content style="fixed-case"><jats:italic>D. bulbifera</jats:italic></jats:styled-content> L. was distinguished with species of sect. <jats:italic>Stenophora</jats:italic> Uline for pennogenin‐type steroidal saponins. <jats:italic>Dioscorea zingiberensis</jats:italic> exhibited far distance from other members of sect. <jats:italic>Stenophora</jats:italic> Uline for two unique saponins. <jats:italic>Dioscorea banzhuana</jats:italic> may be reclassified into sect. <jats:italic>Stenophora</jats:italic>. <jats:italic>Dioscorea</jats:italic> <jats:styled-content style="fixed-case"><jats:italic>nipponica</jats:italic></jats:styled-content> subsp. <jats:italic>rosthornii</jats:italic> and <jats:italic>D. collettii</jats:italic> var. <jats:italic>hypoglauca</jats:italic> might be separated from their original subspecies/varieties as new species, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The chemotaxonomic method was successfully applied in the study of genetic relationships of <jats:italic>Dioscorea</jats:italic> species. This study not only enhanced the understanding of chemical constituents, but also laid basic theoretical foundations for the rational utilisation and chemotaxonomy of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec> Chemotaxonomic studies of 12 <i>Dioscorea</i> species from China by UHPLC‐QTOF‐MS/MS analysis Phytochemical Analysis |
| doi_str_mv |
10.1002/pca.2876 |
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Online |
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Medizin Chemie und Pharmazie Biologie Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft |
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| imprint |
Wiley, 2020 |
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Wiley, 2020 |
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0958-0344 1099-1565 |
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0958-0344 1099-1565 |
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2020 |
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Wiley |
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Phytochemical Analysis |
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49 |
| title |
Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_unstemmed |
Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_full |
Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_fullStr |
Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_full_unstemmed |
Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_short |
Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_sort |
chemotaxonomic studies of 12 <i>dioscorea</i> species from china by uhplc‐qtof‐ms/ms analysis |
| topic |
Complementary and alternative medicine Drug Discovery Plant Science Molecular Medicine General Medicine Biochemistry Food Science Analytical Chemistry |
| url |
http://dx.doi.org/10.1002/pca.2876 |
| publishDate |
2020 |
| physical |
164-182 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p><jats:italic>Dioscorea</jats:italic> species, which contain abundant steroidal saponins, have been used as folk medicines or raw materials to synthesise steroid drugs.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To establish a rapid chemotaxonomic method that will comprehensively resolve confusions about genetic relationships of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A comprehensive strategy using ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (UHPLC‐QTOF‐MS/MS) was firstly proposed to evaluate the chemotaxonomy of 12 species (27 taxa) from China by hierarchical cluster analysis (HCA) based on the variations of the identified metabolites.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twenty‐eight secondary metabolites (mainly steroidal saponins) were identified. The MS<jats:sup><jats:italic>n</jats:italic></jats:sup> fragmentation patterns of DA (a new acetylated steroidal saponin at C‐7 position) were firstly reported. Moreover, eight major steroidal saponins were further quantified simultaneously by UPLC‐QTOF‐MS method. According to HCA results, <jats:styled-content style="fixed-case"><jats:italic>D. bulbifera</jats:italic></jats:styled-content> L. was distinguished with species of sect. <jats:italic>Stenophora</jats:italic> Uline for pennogenin‐type steroidal saponins. <jats:italic>Dioscorea zingiberensis</jats:italic> exhibited far distance from other members of sect. <jats:italic>Stenophora</jats:italic> Uline for two unique saponins. <jats:italic>Dioscorea banzhuana</jats:italic> may be reclassified into sect. <jats:italic>Stenophora</jats:italic>. <jats:italic>Dioscorea</jats:italic> <jats:styled-content style="fixed-case"><jats:italic>nipponica</jats:italic></jats:styled-content> subsp. <jats:italic>rosthornii</jats:italic> and <jats:italic>D. collettii</jats:italic> var. <jats:italic>hypoglauca</jats:italic> might be separated from their original subspecies/varieties as new species, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The chemotaxonomic method was successfully applied in the study of genetic relationships of <jats:italic>Dioscorea</jats:italic> species. This study not only enhanced the understanding of chemical constituents, but also laid basic theoretical foundations for the rational utilisation and chemotaxonomy of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec> |
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| author | Li, Xuejiao, Wang, Ying, Sun, Jiachen, Li, Xia, Zhao, Chengcheng, Zhao, Ping, Man, Shuli, Gao, Wenyuan |
| author_facet | Li, Xuejiao, Wang, Ying, Sun, Jiachen, Li, Xia, Zhao, Chengcheng, Zhao, Ping, Man, Shuli, Gao, Wenyuan, Li, Xuejiao, Wang, Ying, Sun, Jiachen, Li, Xia, Zhao, Chengcheng, Zhao, Ping, Man, Shuli, Gao, Wenyuan |
| author_sort | li, xuejiao |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p><jats:italic>Dioscorea</jats:italic> species, which contain abundant steroidal saponins, have been used as folk medicines or raw materials to synthesise steroid drugs.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To establish a rapid chemotaxonomic method that will comprehensively resolve confusions about genetic relationships of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A comprehensive strategy using ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (UHPLC‐QTOF‐MS/MS) was firstly proposed to evaluate the chemotaxonomy of 12 species (27 taxa) from China by hierarchical cluster analysis (HCA) based on the variations of the identified metabolites.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twenty‐eight secondary metabolites (mainly steroidal saponins) were identified. The MS<jats:sup><jats:italic>n</jats:italic></jats:sup> fragmentation patterns of DA (a new acetylated steroidal saponin at C‐7 position) were firstly reported. Moreover, eight major steroidal saponins were further quantified simultaneously by UPLC‐QTOF‐MS method. According to HCA results, <jats:styled-content style="fixed-case"><jats:italic>D. bulbifera</jats:italic></jats:styled-content> L. was distinguished with species of sect. <jats:italic>Stenophora</jats:italic> Uline for pennogenin‐type steroidal saponins. <jats:italic>Dioscorea zingiberensis</jats:italic> exhibited far distance from other members of sect. <jats:italic>Stenophora</jats:italic> Uline for two unique saponins. <jats:italic>Dioscorea banzhuana</jats:italic> may be reclassified into sect. <jats:italic>Stenophora</jats:italic>. <jats:italic>Dioscorea</jats:italic> <jats:styled-content style="fixed-case"><jats:italic>nipponica</jats:italic></jats:styled-content> subsp. <jats:italic>rosthornii</jats:italic> and <jats:italic>D. collettii</jats:italic> var. <jats:italic>hypoglauca</jats:italic> might be separated from their original subspecies/varieties as new species, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The chemotaxonomic method was successfully applied in the study of genetic relationships of <jats:italic>Dioscorea</jats:italic> species. This study not only enhanced the understanding of chemical constituents, but also laid basic theoretical foundations for the rational utilisation and chemotaxonomy of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec> |
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| spelling | Li, Xuejiao Wang, Ying Sun, Jiachen Li, Xia Zhao, Chengcheng Zhao, Ping Man, Shuli Gao, Wenyuan 0958-0344 1099-1565 Wiley Complementary and alternative medicine Drug Discovery Plant Science Molecular Medicine General Medicine Biochemistry Food Science Analytical Chemistry http://dx.doi.org/10.1002/pca.2876 <jats:title>Abstract</jats:title><jats:sec><jats:title>Introduction</jats:title><jats:p><jats:italic>Dioscorea</jats:italic> species, which contain abundant steroidal saponins, have been used as folk medicines or raw materials to synthesise steroid drugs.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To establish a rapid chemotaxonomic method that will comprehensively resolve confusions about genetic relationships of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A comprehensive strategy using ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (UHPLC‐QTOF‐MS/MS) was firstly proposed to evaluate the chemotaxonomy of 12 species (27 taxa) from China by hierarchical cluster analysis (HCA) based on the variations of the identified metabolites.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Twenty‐eight secondary metabolites (mainly steroidal saponins) were identified. The MS<jats:sup><jats:italic>n</jats:italic></jats:sup> fragmentation patterns of DA (a new acetylated steroidal saponin at C‐7 position) were firstly reported. Moreover, eight major steroidal saponins were further quantified simultaneously by UPLC‐QTOF‐MS method. According to HCA results, <jats:styled-content style="fixed-case"><jats:italic>D. bulbifera</jats:italic></jats:styled-content> L. was distinguished with species of sect. <jats:italic>Stenophora</jats:italic> Uline for pennogenin‐type steroidal saponins. <jats:italic>Dioscorea zingiberensis</jats:italic> exhibited far distance from other members of sect. <jats:italic>Stenophora</jats:italic> Uline for two unique saponins. <jats:italic>Dioscorea banzhuana</jats:italic> may be reclassified into sect. <jats:italic>Stenophora</jats:italic>. <jats:italic>Dioscorea</jats:italic> <jats:styled-content style="fixed-case"><jats:italic>nipponica</jats:italic></jats:styled-content> subsp. <jats:italic>rosthornii</jats:italic> and <jats:italic>D. collettii</jats:italic> var. <jats:italic>hypoglauca</jats:italic> might be separated from their original subspecies/varieties as new species, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The chemotaxonomic method was successfully applied in the study of genetic relationships of <jats:italic>Dioscorea</jats:italic> species. This study not only enhanced the understanding of chemical constituents, but also laid basic theoretical foundations for the rational utilisation and chemotaxonomy of genus <jats:italic>Dioscorea</jats:italic>.</jats:p></jats:sec> Chemotaxonomic studies of 12 <i>Dioscorea</i> species from China by UHPLC‐QTOF‐MS/MS analysis Phytochemical Analysis |
| spellingShingle | Li, Xuejiao, Wang, Ying, Sun, Jiachen, Li, Xia, Zhao, Chengcheng, Zhao, Ping, Man, Shuli, Gao, Wenyuan, Phytochemical Analysis, Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis, Complementary and alternative medicine, Drug Discovery, Plant Science, Molecular Medicine, General Medicine, Biochemistry, Food Science, Analytical Chemistry |
| title | Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_full | Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_fullStr | Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_full_unstemmed | Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_short | Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| title_sort | chemotaxonomic studies of 12 <i>dioscorea</i> species from china by uhplc‐qtof‐ms/ms analysis |
| title_unstemmed | Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC‐QTOF‐MS/MS analysis |
| topic | Complementary and alternative medicine, Drug Discovery, Plant Science, Molecular Medicine, General Medicine, Biochemistry, Food Science, Analytical Chemistry |
| url | http://dx.doi.org/10.1002/pca.2876 |