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Lamina‐specific synaptic connections of hippocampal neurons in vitro
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| Zeitschriftentitel: | Journal of Neurobiology |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Neurobiology, 26, 1995, 3, S. 350-359 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Frotscher, M. Heimrich, B. Frotscher, M. Heimrich, B. |
|---|---|
| author |
Frotscher, M. Heimrich, B. |
| spellingShingle |
Frotscher, M. Heimrich, B. Journal of Neurobiology Lamina‐specific synaptic connections of hippocampal neurons in vitro Cellular and Molecular Neuroscience General Neuroscience |
| author_sort |
frotscher, m. |
| spelling |
Frotscher, M. Heimrich, B. 0022-3034 1097-4695 Wiley Cellular and Molecular Neuroscience General Neuroscience http://dx.doi.org/10.1002/neu.480260307 <jats:title>Abstract</jats:title><jats:p>By using slice cultures as a model, we demonstrate here that different target selectivities exist among the various afferent fibers to the hippocampus. As in intact animals, septohippocampal cholinergic fibers, provided by a slice culture of septum, innervate a co‐cultured slice of hippocampus diffusely, that is, without forming distinct layers of termination. As <jats:italic>in vivo</jats:italic>, the septal cholinergic fibers establish synapses with a variety of target cells. Conversely, fibers from an entorhinal slice co‐cultured to a hippocampal slice display their normal laminar specificity. They preferentially terminate in the outer molecular layer of the fascia dentata, thereby selectively contacting peripheral dendrites of the granule cells. This preferential termination on peripheral dendritic segments is remarkable, since these fibers do not have to compete with commissural fibers, hypothalamic fibers, and septal afferents for dendritic space under these culture conditions. Moreover, in triplet cultures in which first two hippocampal slices were co‐cultured and then, with a delay of 5 days, an entorhinal slice was added, the fibers from the entorhinal slice and those from the hippocampal culture terminated in their appropriate layers in the hippocampal target culture. However, in this approach the normal sequence of ingrowth of these two afferents was reversed. In normal ontogenetic development, entorhinal afferents arrive in the hippocampus before the commissural fibers. The results show that there are different degrees of target selectivity of hippocampal afferents and that the characteristic lamination of certain afferent fibers in the hippocampus is not determined by their sequential ingrowth during development. © 1995 John Wiley & Sons, Inc.</jats:p> Lamina‐specific synaptic connections of hippocampal neurons <i>in vitro</i> Journal of Neurobiology |
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1995 |
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Journal of Neurobiology |
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49 |
| title |
Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_unstemmed |
Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_full |
Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_fullStr |
Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_full_unstemmed |
Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_short |
Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_sort |
lamina‐specific synaptic connections of hippocampal neurons <i>in vitro</i> |
| topic |
Cellular and Molecular Neuroscience General Neuroscience |
| url |
http://dx.doi.org/10.1002/neu.480260307 |
| publishDate |
1995 |
| physical |
350-359 |
| description |
<jats:title>Abstract</jats:title><jats:p>By using slice cultures as a model, we demonstrate here that different target selectivities exist among the various afferent fibers to the hippocampus. As in intact animals, septohippocampal cholinergic fibers, provided by a slice culture of septum, innervate a co‐cultured slice of hippocampus diffusely, that is, without forming distinct layers of termination. As <jats:italic>in vivo</jats:italic>, the septal cholinergic fibers establish synapses with a variety of target cells. Conversely, fibers from an entorhinal slice co‐cultured to a hippocampal slice display their normal laminar specificity. They preferentially terminate in the outer molecular layer of the fascia dentata, thereby selectively contacting peripheral dendrites of the granule cells. This preferential termination on peripheral dendritic segments is remarkable, since these fibers do not have to compete with commissural fibers, hypothalamic fibers, and septal afferents for dendritic space under these culture conditions. Moreover, in triplet cultures in which first two hippocampal slices were co‐cultured and then, with a delay of 5 days, an entorhinal slice was added, the fibers from the entorhinal slice and those from the hippocampal culture terminated in their appropriate layers in the hippocampal target culture. However, in this approach the normal sequence of ingrowth of these two afferents was reversed. In normal ontogenetic development, entorhinal afferents arrive in the hippocampus before the commissural fibers. The results show that there are different degrees of target selectivity of hippocampal afferents and that the characteristic lamination of certain afferent fibers in the hippocampus is not determined by their sequential ingrowth during development. © 1995 John Wiley & Sons, Inc.</jats:p> |
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| description | <jats:title>Abstract</jats:title><jats:p>By using slice cultures as a model, we demonstrate here that different target selectivities exist among the various afferent fibers to the hippocampus. As in intact animals, septohippocampal cholinergic fibers, provided by a slice culture of septum, innervate a co‐cultured slice of hippocampus diffusely, that is, without forming distinct layers of termination. As <jats:italic>in vivo</jats:italic>, the septal cholinergic fibers establish synapses with a variety of target cells. Conversely, fibers from an entorhinal slice co‐cultured to a hippocampal slice display their normal laminar specificity. They preferentially terminate in the outer molecular layer of the fascia dentata, thereby selectively contacting peripheral dendrites of the granule cells. This preferential termination on peripheral dendritic segments is remarkable, since these fibers do not have to compete with commissural fibers, hypothalamic fibers, and septal afferents for dendritic space under these culture conditions. Moreover, in triplet cultures in which first two hippocampal slices were co‐cultured and then, with a delay of 5 days, an entorhinal slice was added, the fibers from the entorhinal slice and those from the hippocampal culture terminated in their appropriate layers in the hippocampal target culture. However, in this approach the normal sequence of ingrowth of these two afferents was reversed. In normal ontogenetic development, entorhinal afferents arrive in the hippocampus before the commissural fibers. The results show that there are different degrees of target selectivity of hippocampal afferents and that the characteristic lamination of certain afferent fibers in the hippocampus is not determined by their sequential ingrowth during development. © 1995 John Wiley & Sons, Inc.</jats:p> |
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| spelling | Frotscher, M. Heimrich, B. 0022-3034 1097-4695 Wiley Cellular and Molecular Neuroscience General Neuroscience http://dx.doi.org/10.1002/neu.480260307 <jats:title>Abstract</jats:title><jats:p>By using slice cultures as a model, we demonstrate here that different target selectivities exist among the various afferent fibers to the hippocampus. As in intact animals, septohippocampal cholinergic fibers, provided by a slice culture of septum, innervate a co‐cultured slice of hippocampus diffusely, that is, without forming distinct layers of termination. As <jats:italic>in vivo</jats:italic>, the septal cholinergic fibers establish synapses with a variety of target cells. Conversely, fibers from an entorhinal slice co‐cultured to a hippocampal slice display their normal laminar specificity. They preferentially terminate in the outer molecular layer of the fascia dentata, thereby selectively contacting peripheral dendrites of the granule cells. This preferential termination on peripheral dendritic segments is remarkable, since these fibers do not have to compete with commissural fibers, hypothalamic fibers, and septal afferents for dendritic space under these culture conditions. Moreover, in triplet cultures in which first two hippocampal slices were co‐cultured and then, with a delay of 5 days, an entorhinal slice was added, the fibers from the entorhinal slice and those from the hippocampal culture terminated in their appropriate layers in the hippocampal target culture. However, in this approach the normal sequence of ingrowth of these two afferents was reversed. In normal ontogenetic development, entorhinal afferents arrive in the hippocampus before the commissural fibers. The results show that there are different degrees of target selectivity of hippocampal afferents and that the characteristic lamination of certain afferent fibers in the hippocampus is not determined by their sequential ingrowth during development. © 1995 John Wiley & Sons, Inc.</jats:p> Lamina‐specific synaptic connections of hippocampal neurons <i>in vitro</i> Journal of Neurobiology |
| spellingShingle | Frotscher, M., Heimrich, B., Journal of Neurobiology, Lamina‐specific synaptic connections of hippocampal neurons in vitro, Cellular and Molecular Neuroscience, General Neuroscience |
| title | Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_full | Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_fullStr | Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_full_unstemmed | Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_short | Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| title_sort | lamina‐specific synaptic connections of hippocampal neurons <i>in vitro</i> |
| title_unstemmed | Lamina‐specific synaptic connections of hippocampal neurons in vitro |
| topic | Cellular and Molecular Neuroscience, General Neuroscience |
| url | http://dx.doi.org/10.1002/neu.480260307 |