Eintrag weiter verarbeiten
Genetics of inclusion‐body myositis
Gespeichert in:
Zeitschriftentitel: | Muscle & Nerve |
---|---|
Personen und Körperschaften: | , , |
In: | Muscle & Nerve, 35, 2007, 5, S. 549-561 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Needham, M. Mastaglia, F.L. Garlepp, M.J. Needham, M. Mastaglia, F.L. Garlepp, M.J. |
---|---|
author |
Needham, M. Mastaglia, F.L. Garlepp, M.J. |
spellingShingle |
Needham, M. Mastaglia, F.L. Garlepp, M.J. Muscle & Nerve Genetics of inclusion‐body myositis Physiology (medical) Cellular and Molecular Neuroscience Neurology (clinical) Physiology |
author_sort |
needham, m. |
spelling |
Needham, M. Mastaglia, F.L. Garlepp, M.J. 0148-639X 1097-4598 Wiley Physiology (medical) Cellular and Molecular Neuroscience Neurology (clinical) Physiology http://dx.doi.org/10.1002/mus.20766 <jats:title>Abstract</jats:title><jats:p>Sporadic inclusion‐body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet‐unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility comes from studies of the major histocompatibility complex (MHC), where different combinations of alleles have been associated with sIBM in different ethnic groups. The rare occurrence of familial cases of inclusion‐body myositis (fIBM) adds additional evidence for genetic susceptibility. Other candidate genes such as those encoding some of the proteins accumulating in muscle fibers have been investigated, with negative results. The increased understanding of related disorders, the hereditary inclusion‐body myopathies (hIBM), may also provide clues to the underlying pathogenesis of sIBM, but to date there is no indication that the genes responsible for these conditions are involved in sIBM. This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM. Muscle Nerve, 2007</jats:p> Genetics of inclusion‐body myositis Muscle & Nerve |
doi_str_mv |
10.1002/mus.20766 |
facet_avail |
Online |
finc_class_facet |
Biologie Psychologie |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9tdXMuMjA3NjY |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9tdXMuMjA3NjY |
institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
imprint |
Wiley, 2007 |
imprint_str_mv |
Wiley, 2007 |
issn |
0148-639X 1097-4598 |
issn_str_mv |
0148-639X 1097-4598 |
language |
English |
mega_collection |
Wiley (CrossRef) |
match_str |
needham2007geneticsofinclusionbodymyositis |
publishDateSort |
2007 |
publisher |
Wiley |
recordtype |
ai |
record_format |
ai |
series |
Muscle & Nerve |
source_id |
49 |
title |
Genetics of inclusion‐body myositis |
title_unstemmed |
Genetics of inclusion‐body myositis |
title_full |
Genetics of inclusion‐body myositis |
title_fullStr |
Genetics of inclusion‐body myositis |
title_full_unstemmed |
Genetics of inclusion‐body myositis |
title_short |
Genetics of inclusion‐body myositis |
title_sort |
genetics of inclusion‐body myositis |
topic |
Physiology (medical) Cellular and Molecular Neuroscience Neurology (clinical) Physiology |
url |
http://dx.doi.org/10.1002/mus.20766 |
publishDate |
2007 |
physical |
549-561 |
description |
<jats:title>Abstract</jats:title><jats:p>Sporadic inclusion‐body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet‐unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility comes from studies of the major histocompatibility complex (MHC), where different combinations of alleles have been associated with sIBM in different ethnic groups. The rare occurrence of familial cases of inclusion‐body myositis (fIBM) adds additional evidence for genetic susceptibility. Other candidate genes such as those encoding some of the proteins accumulating in muscle fibers have been investigated, with negative results. The increased understanding of related disorders, the hereditary inclusion‐body myopathies (hIBM), may also provide clues to the underlying pathogenesis of sIBM, but to date there is no indication that the genes responsible for these conditions are involved in sIBM. This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM. Muscle Nerve, 2007</jats:p> |
container_issue |
5 |
container_start_page |
549 |
container_title |
Muscle & Nerve |
container_volume |
35 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792335716872617988 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T14:48:56.869Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Genetics+of+inclusion%E2%80%90body+myositis&rft.date=2007-05-01&genre=article&issn=1097-4598&volume=35&issue=5&spage=549&epage=561&pages=549-561&jtitle=Muscle+%26+Nerve&atitle=Genetics+of+inclusion%E2%80%90body+myositis&aulast=Garlepp&aufirst=M.J.&rft_id=info%3Adoi%2F10.1002%2Fmus.20766&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792335716872617988 |
author | Needham, M., Mastaglia, F.L., Garlepp, M.J. |
author_facet | Needham, M., Mastaglia, F.L., Garlepp, M.J., Needham, M., Mastaglia, F.L., Garlepp, M.J. |
author_sort | needham, m. |
container_issue | 5 |
container_start_page | 549 |
container_title | Muscle & Nerve |
container_volume | 35 |
description | <jats:title>Abstract</jats:title><jats:p>Sporadic inclusion‐body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet‐unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility comes from studies of the major histocompatibility complex (MHC), where different combinations of alleles have been associated with sIBM in different ethnic groups. The rare occurrence of familial cases of inclusion‐body myositis (fIBM) adds additional evidence for genetic susceptibility. Other candidate genes such as those encoding some of the proteins accumulating in muscle fibers have been investigated, with negative results. The increased understanding of related disorders, the hereditary inclusion‐body myopathies (hIBM), may also provide clues to the underlying pathogenesis of sIBM, but to date there is no indication that the genes responsible for these conditions are involved in sIBM. This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM. Muscle Nerve, 2007</jats:p> |
doi_str_mv | 10.1002/mus.20766 |
facet_avail | Online |
finc_class_facet | Biologie, Psychologie |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9tdXMuMjA3NjY |
imprint | Wiley, 2007 |
imprint_str_mv | Wiley, 2007 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
issn | 0148-639X, 1097-4598 |
issn_str_mv | 0148-639X, 1097-4598 |
language | English |
last_indexed | 2024-03-01T14:48:56.869Z |
match_str | needham2007geneticsofinclusionbodymyositis |
mega_collection | Wiley (CrossRef) |
physical | 549-561 |
publishDate | 2007 |
publishDateSort | 2007 |
publisher | Wiley |
record_format | ai |
recordtype | ai |
series | Muscle & Nerve |
source_id | 49 |
spelling | Needham, M. Mastaglia, F.L. Garlepp, M.J. 0148-639X 1097-4598 Wiley Physiology (medical) Cellular and Molecular Neuroscience Neurology (clinical) Physiology http://dx.doi.org/10.1002/mus.20766 <jats:title>Abstract</jats:title><jats:p>Sporadic inclusion‐body myositis (sIBM) is the most common acquired muscle disease in Caucasians over the age of 50 years. Pathologically it is marked by inflammatory, degenerative, and mitochondrial changes that interact in a yet‐unknown way to cause progressive muscle degeneration and weakness. The cause of the disease is unknown, but it is thought to involve a complex interplay between environmental factors, genetic susceptibility, and aging. The strongest evidence for genetic susceptibility comes from studies of the major histocompatibility complex (MHC), where different combinations of alleles have been associated with sIBM in different ethnic groups. The rare occurrence of familial cases of inclusion‐body myositis (fIBM) adds additional evidence for genetic susceptibility. Other candidate genes such as those encoding some of the proteins accumulating in muscle fibers have been investigated, with negative results. The increased understanding of related disorders, the hereditary inclusion‐body myopathies (hIBM), may also provide clues to the underlying pathogenesis of sIBM, but to date there is no indication that the genes responsible for these conditions are involved in sIBM. This review summarizes current understanding of the contribution of genetic susceptibility factors to the development of sIBM. Muscle Nerve, 2007</jats:p> Genetics of inclusion‐body myositis Muscle & Nerve |
spellingShingle | Needham, M., Mastaglia, F.L., Garlepp, M.J., Muscle & Nerve, Genetics of inclusion‐body myositis, Physiology (medical), Cellular and Molecular Neuroscience, Neurology (clinical), Physiology |
title | Genetics of inclusion‐body myositis |
title_full | Genetics of inclusion‐body myositis |
title_fullStr | Genetics of inclusion‐body myositis |
title_full_unstemmed | Genetics of inclusion‐body myositis |
title_short | Genetics of inclusion‐body myositis |
title_sort | genetics of inclusion‐body myositis |
title_unstemmed | Genetics of inclusion‐body myositis |
topic | Physiology (medical), Cellular and Molecular Neuroscience, Neurology (clinical), Physiology |
url | http://dx.doi.org/10.1002/mus.20766 |