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Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats
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| Zeitschriftentitel: | Molecular Nutrition & Food Research |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Molecular Nutrition & Food Research, 59, 2015, 5, S. 865-878 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Ribas‐Latre, Aleix Del Bas, Josep M. Baselga‐Escudero, Laura Casanova, Ester Arola‐Arnal, Anna Salvadó, Maria‐Josepa Arola, Lluís Bladé, Cinta Ribas‐Latre, Aleix Del Bas, Josep M. Baselga‐Escudero, Laura Casanova, Ester Arola‐Arnal, Anna Salvadó, Maria‐Josepa Arola, Lluís Bladé, Cinta |
|---|---|
| author |
Ribas‐Latre, Aleix Del Bas, Josep M. Baselga‐Escudero, Laura Casanova, Ester Arola‐Arnal, Anna Salvadó, Maria‐Josepa Arola, Lluís Bladé, Cinta |
| spellingShingle |
Ribas‐Latre, Aleix Del Bas, Josep M. Baselga‐Escudero, Laura Casanova, Ester Arola‐Arnal, Anna Salvadó, Maria‐Josepa Arola, Lluís Bladé, Cinta Molecular Nutrition & Food Research Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats Food Science Biotechnology |
| author_sort |
ribas‐latre, aleix |
| spelling |
Ribas‐Latre, Aleix Del Bas, Josep M. Baselga‐Escudero, Laura Casanova, Ester Arola‐Arnal, Anna Salvadó, Maria‐Josepa Arola, Lluís Bladé, Cinta 1613-4125 1613-4133 Wiley Food Science Biotechnology http://dx.doi.org/10.1002/mnfr.201400571 <jats:sec><jats:title>Scope</jats:title><jats:p>Circadian rhythms allow organisms to anticipate and adapt to environmental changes, and food components can adjust internal rhythms. Proanthocyanidins improve cardiovascular risk factors that exhibit circadian oscillations. Therefore, the aim of the current study was to determine whether proanthocyanidins can modulate body rhythms.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>Male Wistar rats were orally gavaged with 250 mg grape seed proanthocyanidin extract (GSPE)/kg body weight at zeitgeber time (ZT) 0 (light on). Phenotypic biorhythm was evaluated by measuring the concentration of plasma melatonin and metabolites, using MNR‐metabolomics, at several ZT. Remarkably, GSPE treatment maintained nocturnal melatonin levels at ZT3 and altered the oscillations of some metabolites in plasma. Quantification of expression of clock‐core (<jats:italic>Clock, Bmal1, Per2, Rorα, Rev‐erbα</jats:italic>) and clock‐controlled (<jats:italic>Nampt</jats:italic>) genes in the hypothalamus by RT‐PCR showed that this phenotypic alteration was concomitant with the modulation of the expression pattern of <jats:italic>Bmal1</jats:italic> and <jats:italic>Nampt</jats:italic>. However, GSPE did not modulate the nocturnal expression of clock genes when administered at ZT12 (light off).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>PAs could have chronobiological properties, although their activity depends largely on the time of administration.</jats:p></jats:sec> Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats Molecular Nutrition & Food Research |
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10.1002/mnfr.201400571 |
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Online |
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Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft Biologie Technik |
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| title |
Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_unstemmed |
Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_full |
Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_fullStr |
Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_full_unstemmed |
Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_short |
Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_sort |
dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| topic |
Food Science Biotechnology |
| url |
http://dx.doi.org/10.1002/mnfr.201400571 |
| publishDate |
2015 |
| physical |
865-878 |
| description |
<jats:sec><jats:title>Scope</jats:title><jats:p>Circadian rhythms allow organisms to anticipate and adapt to environmental changes, and food components can adjust internal rhythms. Proanthocyanidins improve cardiovascular risk factors that exhibit circadian oscillations. Therefore, the aim of the current study was to determine whether proanthocyanidins can modulate body rhythms.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>Male Wistar rats were orally gavaged with 250 mg grape seed proanthocyanidin extract (GSPE)/kg body weight at zeitgeber time (ZT) 0 (light on). Phenotypic biorhythm was evaluated by measuring the concentration of plasma melatonin and metabolites, using MNR‐metabolomics, at several ZT. Remarkably, GSPE treatment maintained nocturnal melatonin levels at ZT3 and altered the oscillations of some metabolites in plasma. Quantification of expression of clock‐core (<jats:italic>Clock, Bmal1, Per2, Rorα, Rev‐erbα</jats:italic>) and clock‐controlled (<jats:italic>Nampt</jats:italic>) genes in the hypothalamus by RT‐PCR showed that this phenotypic alteration was concomitant with the modulation of the expression pattern of <jats:italic>Bmal1</jats:italic> and <jats:italic>Nampt</jats:italic>. However, GSPE did not modulate the nocturnal expression of clock genes when administered at ZT12 (light off).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>PAs could have chronobiological properties, although their activity depends largely on the time of administration.</jats:p></jats:sec> |
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| author | Ribas‐Latre, Aleix, Del Bas, Josep M., Baselga‐Escudero, Laura, Casanova, Ester, Arola‐Arnal, Anna, Salvadó, Maria‐Josepa, Arola, Lluís, Bladé, Cinta |
| author_facet | Ribas‐Latre, Aleix, Del Bas, Josep M., Baselga‐Escudero, Laura, Casanova, Ester, Arola‐Arnal, Anna, Salvadó, Maria‐Josepa, Arola, Lluís, Bladé, Cinta, Ribas‐Latre, Aleix, Del Bas, Josep M., Baselga‐Escudero, Laura, Casanova, Ester, Arola‐Arnal, Anna, Salvadó, Maria‐Josepa, Arola, Lluís, Bladé, Cinta |
| author_sort | ribas‐latre, aleix |
| container_issue | 5 |
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| container_title | Molecular Nutrition & Food Research |
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| description | <jats:sec><jats:title>Scope</jats:title><jats:p>Circadian rhythms allow organisms to anticipate and adapt to environmental changes, and food components can adjust internal rhythms. Proanthocyanidins improve cardiovascular risk factors that exhibit circadian oscillations. Therefore, the aim of the current study was to determine whether proanthocyanidins can modulate body rhythms.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>Male Wistar rats were orally gavaged with 250 mg grape seed proanthocyanidin extract (GSPE)/kg body weight at zeitgeber time (ZT) 0 (light on). Phenotypic biorhythm was evaluated by measuring the concentration of plasma melatonin and metabolites, using MNR‐metabolomics, at several ZT. Remarkably, GSPE treatment maintained nocturnal melatonin levels at ZT3 and altered the oscillations of some metabolites in plasma. Quantification of expression of clock‐core (<jats:italic>Clock, Bmal1, Per2, Rorα, Rev‐erbα</jats:italic>) and clock‐controlled (<jats:italic>Nampt</jats:italic>) genes in the hypothalamus by RT‐PCR showed that this phenotypic alteration was concomitant with the modulation of the expression pattern of <jats:italic>Bmal1</jats:italic> and <jats:italic>Nampt</jats:italic>. However, GSPE did not modulate the nocturnal expression of clock genes when administered at ZT12 (light off).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>PAs could have chronobiological properties, although their activity depends largely on the time of administration.</jats:p></jats:sec> |
| doi_str_mv | 10.1002/mnfr.201400571 |
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| imprint_str_mv | Wiley, 2015 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161 |
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| spelling | Ribas‐Latre, Aleix Del Bas, Josep M. Baselga‐Escudero, Laura Casanova, Ester Arola‐Arnal, Anna Salvadó, Maria‐Josepa Arola, Lluís Bladé, Cinta 1613-4125 1613-4133 Wiley Food Science Biotechnology http://dx.doi.org/10.1002/mnfr.201400571 <jats:sec><jats:title>Scope</jats:title><jats:p>Circadian rhythms allow organisms to anticipate and adapt to environmental changes, and food components can adjust internal rhythms. Proanthocyanidins improve cardiovascular risk factors that exhibit circadian oscillations. Therefore, the aim of the current study was to determine whether proanthocyanidins can modulate body rhythms.</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>Male Wistar rats were orally gavaged with 250 mg grape seed proanthocyanidin extract (GSPE)/kg body weight at zeitgeber time (ZT) 0 (light on). Phenotypic biorhythm was evaluated by measuring the concentration of plasma melatonin and metabolites, using MNR‐metabolomics, at several ZT. Remarkably, GSPE treatment maintained nocturnal melatonin levels at ZT3 and altered the oscillations of some metabolites in plasma. Quantification of expression of clock‐core (<jats:italic>Clock, Bmal1, Per2, Rorα, Rev‐erbα</jats:italic>) and clock‐controlled (<jats:italic>Nampt</jats:italic>) genes in the hypothalamus by RT‐PCR showed that this phenotypic alteration was concomitant with the modulation of the expression pattern of <jats:italic>Bmal1</jats:italic> and <jats:italic>Nampt</jats:italic>. However, GSPE did not modulate the nocturnal expression of clock genes when administered at ZT12 (light off).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>PAs could have chronobiological properties, although their activity depends largely on the time of administration.</jats:p></jats:sec> Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats Molecular Nutrition & Food Research |
| spellingShingle | Ribas‐Latre, Aleix, Del Bas, Josep M., Baselga‐Escudero, Laura, Casanova, Ester, Arola‐Arnal, Anna, Salvadó, Maria‐Josepa, Arola, Lluís, Bladé, Cinta, Molecular Nutrition & Food Research, Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats, Food Science, Biotechnology |
| title | Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_full | Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_fullStr | Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_full_unstemmed | Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_short | Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_sort | dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| title_unstemmed | Dietary proanthocyanidins modulate melatonin levels in plasma and the expression pattern of clock genes in the hypothalamus of rats |
| topic | Food Science, Biotechnology |
| url | http://dx.doi.org/10.1002/mnfr.201400571 |