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High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin
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| Zeitschriftentitel: | Molecular Nutrition & Food Research |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Molecular Nutrition & Food Research, 54, 2010, S1 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Yamane, Takumi Kobayashi‐Hattori, Kazuo Oishi, Yuichi Takita, Toshichika Yamane, Takumi Kobayashi‐Hattori, Kazuo Oishi, Yuichi Takita, Toshichika |
|---|---|
| author |
Yamane, Takumi Kobayashi‐Hattori, Kazuo Oishi, Yuichi Takita, Toshichika |
| spellingShingle |
Yamane, Takumi Kobayashi‐Hattori, Kazuo Oishi, Yuichi Takita, Toshichika Molecular Nutrition & Food Research High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin Food Science Biotechnology |
| author_sort |
yamane, takumi |
| spelling |
Yamane, Takumi Kobayashi‐Hattori, Kazuo Oishi, Yuichi Takita, Toshichika 1613-4125 1613-4133 Wiley Food Science Biotechnology http://dx.doi.org/10.1002/mnfr.201000022 <jats:title>Abstract</jats:title><jats:p>Although it is known that nutritional conditions affect the skin function, little information is available on the effect of a high‐fat (HF) diet on skin. In this study, Sprague–Dawley rats were fed HF diets for 28 days, and we investigated the effect of this diet on type I tropocollagen and hyaluronan in rat skin. The HF diets reduced the levels of type I tropocollagen, <jats:italic>COL1A1</jats:italic> mRNA, hyaluronan, and <jats:italic>rat hyaluronan synthase</jats:italic> (<jats:italic>rhas</jats:italic>)<jats:italic>2</jats:italic> mRNA, which play a primary role in hyaluronan synthase in the dermis. However, <jats:italic>rhas3</jats:italic> mRNA level in the skin was increased. The HF diets also decreased the skin mRNA expression of <jats:italic>transforming growth factor</jats:italic> (<jats:italic>TGF</jats:italic>)‐<jats:italic>β1</jats:italic>, which enhances the expression of <jats:italic>COL1A1</jats:italic> and <jats:italic>rhas2</jats:italic> mRNA and decreases <jats:italic>rhas3</jats:italic> mRNA expression, and decreased the hepatic mRNA expression of <jats:italic>insulin‐like growth factor (IGF)‐I</jats:italic>, which enhances <jats:italic>COL1A1, rhas2,</jats:italic> and <jats:italic>TGF</jats:italic>‐<jats:italic>β1</jats:italic> mRNA expression. The serum level of adiponectin, which promotes the syntheses of type I collagen and hyaluronan, was decreased in the HF diet groups. These findings suggest that an HF diet reduces the levels of type I tropocollagen and hyaluronan in the skin by suppressing the action of TGF‐β1, IGF‐I and adiponectin, and these effects are deleterious for skin function.</jats:p> High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin Molecular Nutrition & Food Research |
| doi_str_mv |
10.1002/mnfr.201000022 |
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Online |
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| title |
High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_unstemmed |
High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_full |
High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_fullStr |
High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_full_unstemmed |
High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_short |
High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_sort |
high‐fat diet reduces levels of type i tropocollagen and hyaluronan in rat skin |
| topic |
Food Science Biotechnology |
| url |
http://dx.doi.org/10.1002/mnfr.201000022 |
| publishDate |
2010 |
| physical |
|
| description |
<jats:title>Abstract</jats:title><jats:p>Although it is known that nutritional conditions affect the skin function, little information is available on the effect of a high‐fat (HF) diet on skin. In this study, Sprague–Dawley rats were fed HF diets for 28 days, and we investigated the effect of this diet on type I tropocollagen and hyaluronan in rat skin. The HF diets reduced the levels of type I tropocollagen, <jats:italic>COL1A1</jats:italic> mRNA, hyaluronan, and <jats:italic>rat hyaluronan synthase</jats:italic> (<jats:italic>rhas</jats:italic>)<jats:italic>2</jats:italic> mRNA, which play a primary role in hyaluronan synthase in the dermis. However, <jats:italic>rhas3</jats:italic> mRNA level in the skin was increased. The HF diets also decreased the skin mRNA expression of <jats:italic>transforming growth factor</jats:italic> (<jats:italic>TGF</jats:italic>)‐<jats:italic>β1</jats:italic>, which enhances the expression of <jats:italic>COL1A1</jats:italic> and <jats:italic>rhas2</jats:italic> mRNA and decreases <jats:italic>rhas3</jats:italic> mRNA expression, and decreased the hepatic mRNA expression of <jats:italic>insulin‐like growth factor (IGF)‐I</jats:italic>, which enhances <jats:italic>COL1A1, rhas2,</jats:italic> and <jats:italic>TGF</jats:italic>‐<jats:italic>β1</jats:italic> mRNA expression. The serum level of adiponectin, which promotes the syntheses of type I collagen and hyaluronan, was decreased in the HF diet groups. These findings suggest that an HF diet reduces the levels of type I tropocollagen and hyaluronan in the skin by suppressing the action of TGF‐β1, IGF‐I and adiponectin, and these effects are deleterious for skin function.</jats:p> |
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| author | Yamane, Takumi, Kobayashi‐Hattori, Kazuo, Oishi, Yuichi, Takita, Toshichika |
| author_facet | Yamane, Takumi, Kobayashi‐Hattori, Kazuo, Oishi, Yuichi, Takita, Toshichika, Yamane, Takumi, Kobayashi‐Hattori, Kazuo, Oishi, Yuichi, Takita, Toshichika |
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| description | <jats:title>Abstract</jats:title><jats:p>Although it is known that nutritional conditions affect the skin function, little information is available on the effect of a high‐fat (HF) diet on skin. In this study, Sprague–Dawley rats were fed HF diets for 28 days, and we investigated the effect of this diet on type I tropocollagen and hyaluronan in rat skin. The HF diets reduced the levels of type I tropocollagen, <jats:italic>COL1A1</jats:italic> mRNA, hyaluronan, and <jats:italic>rat hyaluronan synthase</jats:italic> (<jats:italic>rhas</jats:italic>)<jats:italic>2</jats:italic> mRNA, which play a primary role in hyaluronan synthase in the dermis. However, <jats:italic>rhas3</jats:italic> mRNA level in the skin was increased. The HF diets also decreased the skin mRNA expression of <jats:italic>transforming growth factor</jats:italic> (<jats:italic>TGF</jats:italic>)‐<jats:italic>β1</jats:italic>, which enhances the expression of <jats:italic>COL1A1</jats:italic> and <jats:italic>rhas2</jats:italic> mRNA and decreases <jats:italic>rhas3</jats:italic> mRNA expression, and decreased the hepatic mRNA expression of <jats:italic>insulin‐like growth factor (IGF)‐I</jats:italic>, which enhances <jats:italic>COL1A1, rhas2,</jats:italic> and <jats:italic>TGF</jats:italic>‐<jats:italic>β1</jats:italic> mRNA expression. The serum level of adiponectin, which promotes the syntheses of type I collagen and hyaluronan, was decreased in the HF diet groups. These findings suggest that an HF diet reduces the levels of type I tropocollagen and hyaluronan in the skin by suppressing the action of TGF‐β1, IGF‐I and adiponectin, and these effects are deleterious for skin function.</jats:p> |
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| institution | DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1 |
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| spelling | Yamane, Takumi Kobayashi‐Hattori, Kazuo Oishi, Yuichi Takita, Toshichika 1613-4125 1613-4133 Wiley Food Science Biotechnology http://dx.doi.org/10.1002/mnfr.201000022 <jats:title>Abstract</jats:title><jats:p>Although it is known that nutritional conditions affect the skin function, little information is available on the effect of a high‐fat (HF) diet on skin. In this study, Sprague–Dawley rats were fed HF diets for 28 days, and we investigated the effect of this diet on type I tropocollagen and hyaluronan in rat skin. The HF diets reduced the levels of type I tropocollagen, <jats:italic>COL1A1</jats:italic> mRNA, hyaluronan, and <jats:italic>rat hyaluronan synthase</jats:italic> (<jats:italic>rhas</jats:italic>)<jats:italic>2</jats:italic> mRNA, which play a primary role in hyaluronan synthase in the dermis. However, <jats:italic>rhas3</jats:italic> mRNA level in the skin was increased. The HF diets also decreased the skin mRNA expression of <jats:italic>transforming growth factor</jats:italic> (<jats:italic>TGF</jats:italic>)‐<jats:italic>β1</jats:italic>, which enhances the expression of <jats:italic>COL1A1</jats:italic> and <jats:italic>rhas2</jats:italic> mRNA and decreases <jats:italic>rhas3</jats:italic> mRNA expression, and decreased the hepatic mRNA expression of <jats:italic>insulin‐like growth factor (IGF)‐I</jats:italic>, which enhances <jats:italic>COL1A1, rhas2,</jats:italic> and <jats:italic>TGF</jats:italic>‐<jats:italic>β1</jats:italic> mRNA expression. The serum level of adiponectin, which promotes the syntheses of type I collagen and hyaluronan, was decreased in the HF diet groups. These findings suggest that an HF diet reduces the levels of type I tropocollagen and hyaluronan in the skin by suppressing the action of TGF‐β1, IGF‐I and adiponectin, and these effects are deleterious for skin function.</jats:p> High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin Molecular Nutrition & Food Research |
| spellingShingle | Yamane, Takumi, Kobayashi‐Hattori, Kazuo, Oishi, Yuichi, Takita, Toshichika, Molecular Nutrition & Food Research, High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin, Food Science, Biotechnology |
| title | High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_full | High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_fullStr | High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_full_unstemmed | High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_short | High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| title_sort | high‐fat diet reduces levels of type i tropocollagen and hyaluronan in rat skin |
| title_unstemmed | High‐fat diet reduces levels of type I tropocollagen and hyaluronan in rat skin |
| topic | Food Science, Biotechnology |
| url | http://dx.doi.org/10.1002/mnfr.201000022 |