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Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice
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| Zeitschriftentitel: | Molecular Nutrition & Food Research |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Molecular Nutrition & Food Research, 54, 2010, S2 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Bando, Noriko Muraki, Naomi Murota, Kaeko Terao, Junji Yamanishi, Rintaro Bando, Noriko Muraki, Naomi Murota, Kaeko Terao, Junji Yamanishi, Rintaro |
|---|---|
| author |
Bando, Noriko Muraki, Naomi Murota, Kaeko Terao, Junji Yamanishi, Rintaro |
| spellingShingle |
Bando, Noriko Muraki, Naomi Murota, Kaeko Terao, Junji Yamanishi, Rintaro Molecular Nutrition & Food Research Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice Food Science Biotechnology |
| author_sort |
bando, noriko |
| spelling |
Bando, Noriko Muraki, Naomi Murota, Kaeko Terao, Junji Yamanishi, Rintaro 1613-4125 1613-4133 Wiley Food Science Biotechnology http://dx.doi.org/10.1002/mnfr.200900329 <jats:title>Abstract</jats:title><jats:p>β‐Carotene is a carotenoid with a range of reported health benefits besides vitamin A activity. If the enzymatic conversion of β‐carotene to retinal is suppressed in the digestive tract, residual β‐carotene that reaches the tissues increases. We evaluated the function of quercetin and rutin (quercetin‐3‐rutinoside) to increase the accumulation of β‐carotene <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> in BALB/c mice. When the conversion of β‐carotene by a preparation of the murine small intestine was measured <jats:italic>in vitro</jats:italic>, the addition of quercetin or rutin considerably inhibited the conversion. When the levels of hepatic β‐carotene and retinoids were measured among three groups of mice fed a diet supplemented with β‐carotene plus quercetin or rutin or β‐carotene alone (four to six mice <jats:italic>per</jats:italic> group), quercetin increased the level of β‐carotene and decreased the level of retinol, whereas rutin did not. These results demonstrate that quercetin can suppress the conversion of β‐carotene which develops in the cytosol of small intestinal epithelial cells, and that rutin whose rutinose‐moiety prevents being absorbed in the small intestine cannot suppress the conversion <jats:italic>in vivo</jats:italic>. This study offers a novel insight into the interaction between flavonoids and carotenoids with respect to the health benefits from the latter.</jats:p> Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice Molecular Nutrition & Food Research |
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10.1002/mnfr.200900329 |
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Wiley, 2010 |
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Molecular Nutrition & Food Research |
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| title |
Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_unstemmed |
Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_full |
Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_fullStr |
Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_full_unstemmed |
Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_short |
Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_sort |
ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in balb/c mice |
| topic |
Food Science Biotechnology |
| url |
http://dx.doi.org/10.1002/mnfr.200900329 |
| publishDate |
2010 |
| physical |
|
| description |
<jats:title>Abstract</jats:title><jats:p>β‐Carotene is a carotenoid with a range of reported health benefits besides vitamin A activity. If the enzymatic conversion of β‐carotene to retinal is suppressed in the digestive tract, residual β‐carotene that reaches the tissues increases. We evaluated the function of quercetin and rutin (quercetin‐3‐rutinoside) to increase the accumulation of β‐carotene <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> in BALB/c mice. When the conversion of β‐carotene by a preparation of the murine small intestine was measured <jats:italic>in vitro</jats:italic>, the addition of quercetin or rutin considerably inhibited the conversion. When the levels of hepatic β‐carotene and retinoids were measured among three groups of mice fed a diet supplemented with β‐carotene plus quercetin or rutin or β‐carotene alone (four to six mice <jats:italic>per</jats:italic> group), quercetin increased the level of β‐carotene and decreased the level of retinol, whereas rutin did not. These results demonstrate that quercetin can suppress the conversion of β‐carotene which develops in the cytosol of small intestinal epithelial cells, and that rutin whose rutinose‐moiety prevents being absorbed in the small intestine cannot suppress the conversion <jats:italic>in vivo</jats:italic>. This study offers a novel insight into the interaction between flavonoids and carotenoids with respect to the health benefits from the latter.</jats:p> |
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| author | Bando, Noriko, Muraki, Naomi, Murota, Kaeko, Terao, Junji, Yamanishi, Rintaro |
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| description | <jats:title>Abstract</jats:title><jats:p>β‐Carotene is a carotenoid with a range of reported health benefits besides vitamin A activity. If the enzymatic conversion of β‐carotene to retinal is suppressed in the digestive tract, residual β‐carotene that reaches the tissues increases. We evaluated the function of quercetin and rutin (quercetin‐3‐rutinoside) to increase the accumulation of β‐carotene <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> in BALB/c mice. When the conversion of β‐carotene by a preparation of the murine small intestine was measured <jats:italic>in vitro</jats:italic>, the addition of quercetin or rutin considerably inhibited the conversion. When the levels of hepatic β‐carotene and retinoids were measured among three groups of mice fed a diet supplemented with β‐carotene plus quercetin or rutin or β‐carotene alone (four to six mice <jats:italic>per</jats:italic> group), quercetin increased the level of β‐carotene and decreased the level of retinol, whereas rutin did not. These results demonstrate that quercetin can suppress the conversion of β‐carotene which develops in the cytosol of small intestinal epithelial cells, and that rutin whose rutinose‐moiety prevents being absorbed in the small intestine cannot suppress the conversion <jats:italic>in vivo</jats:italic>. This study offers a novel insight into the interaction between flavonoids and carotenoids with respect to the health benefits from the latter.</jats:p> |
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| spelling | Bando, Noriko Muraki, Naomi Murota, Kaeko Terao, Junji Yamanishi, Rintaro 1613-4125 1613-4133 Wiley Food Science Biotechnology http://dx.doi.org/10.1002/mnfr.200900329 <jats:title>Abstract</jats:title><jats:p>β‐Carotene is a carotenoid with a range of reported health benefits besides vitamin A activity. If the enzymatic conversion of β‐carotene to retinal is suppressed in the digestive tract, residual β‐carotene that reaches the tissues increases. We evaluated the function of quercetin and rutin (quercetin‐3‐rutinoside) to increase the accumulation of β‐carotene <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> in BALB/c mice. When the conversion of β‐carotene by a preparation of the murine small intestine was measured <jats:italic>in vitro</jats:italic>, the addition of quercetin or rutin considerably inhibited the conversion. When the levels of hepatic β‐carotene and retinoids were measured among three groups of mice fed a diet supplemented with β‐carotene plus quercetin or rutin or β‐carotene alone (four to six mice <jats:italic>per</jats:italic> group), quercetin increased the level of β‐carotene and decreased the level of retinol, whereas rutin did not. These results demonstrate that quercetin can suppress the conversion of β‐carotene which develops in the cytosol of small intestinal epithelial cells, and that rutin whose rutinose‐moiety prevents being absorbed in the small intestine cannot suppress the conversion <jats:italic>in vivo</jats:italic>. This study offers a novel insight into the interaction between flavonoids and carotenoids with respect to the health benefits from the latter.</jats:p> Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice Molecular Nutrition & Food Research |
| spellingShingle | Bando, Noriko, Muraki, Naomi, Murota, Kaeko, Terao, Junji, Yamanishi, Rintaro, Molecular Nutrition & Food Research, Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice, Food Science, Biotechnology |
| title | Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_full | Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_fullStr | Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_full_unstemmed | Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_short | Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| title_sort | ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in balb/c mice |
| title_unstemmed | Ingested quercetin but not rutin increases accumulation of hepatic β‐carotene in BALB/c mice |
| topic | Food Science, Biotechnology |
| url | http://dx.doi.org/10.1002/mnfr.200900329 |