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A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on
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| Zeitschriftentitel: | Medicinal Research Reviews |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Medicinal Research Reviews, 40, 2020, 1, S. 27-53 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Guo, Meichen Song, Hang Li, Kai Ma, Minchao Liu, Yang Fu, Qiang He, Zhonggui Guo, Meichen Song, Hang Li, Kai Ma, Minchao Liu, Yang Fu, Qiang He, Zhonggui |
|---|---|
| author |
Guo, Meichen Song, Hang Li, Kai Ma, Minchao Liu, Yang Fu, Qiang He, Zhonggui |
| spellingShingle |
Guo, Meichen Song, Hang Li, Kai Ma, Minchao Liu, Yang Fu, Qiang He, Zhonggui Medicinal Research Reviews A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on Drug Discovery Pharmacology Molecular Medicine |
| author_sort |
guo, meichen |
| spelling |
Guo, Meichen Song, Hang Li, Kai Ma, Minchao Liu, Yang Fu, Qiang He, Zhonggui 0198-6325 1098-1128 Wiley Drug Discovery Pharmacology Molecular Medicine http://dx.doi.org/10.1002/med.21595 <jats:title>Abstract</jats:title><jats:p>Fluorescence imaging is a promising visualization tool and possesses the advantages of in situ response and facile operation; thus, it is widely exploited for bioassays. However, traditional fluorophores suffer from concentration limits because they are always quenched when they aggregate, which impedes applications, especially for trace analysis and real‐time monitoring. Recently, novel molecules with aggregation‐induced emission (AIE) characteristics were developed to solve the problems encountered when using traditional organic dyes, because these new molecules exhibit weak or even no fluorescence when they are in free movement states but emit intensely upon the restriction of intramolecular motions. Inspired by the excellent performances of AIE molecules, a substantial number of AIE‐based probes have been designed, synthesized, and applied to various fields to fulfill diverse detection tasks. According to numerous experiments, AIE probes are more practical than traditional fluorescent probes, especially when used in bioassays. To bridge bioimaging and materials engineering, this review provides a comprehensive understanding of the development of AIE bioprobes. It begins with a summary of mechanisms of the AIE phenomenon. Then, the strategies to realize accurate detection using AIE probes are discussed. In addition, typical examples of AIE‐active materials applied in diagnosis, treatment, and nanocarrier tracking are presented. In addition, some challenges are put forward to inspire more ideas in the promising field of AIE‐active materials.</jats:p> A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on Medicinal Research Reviews |
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| title |
A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_unstemmed |
A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_full |
A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_fullStr |
A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_full_unstemmed |
A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_short |
A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_sort |
a new approach to developing diagnostics and therapeutics: aggregation‐induced emission‐based fluorescence turn‐on |
| topic |
Drug Discovery Pharmacology Molecular Medicine |
| url |
http://dx.doi.org/10.1002/med.21595 |
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2020 |
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27-53 |
| description |
<jats:title>Abstract</jats:title><jats:p>Fluorescence imaging is a promising visualization tool and possesses the advantages of in situ response and facile operation; thus, it is widely exploited for bioassays. However, traditional fluorophores suffer from concentration limits because they are always quenched when they aggregate, which impedes applications, especially for trace analysis and real‐time monitoring. Recently, novel molecules with aggregation‐induced emission (AIE) characteristics were developed to solve the problems encountered when using traditional organic dyes, because these new molecules exhibit weak or even no fluorescence when they are in free movement states but emit intensely upon the restriction of intramolecular motions. Inspired by the excellent performances of AIE molecules, a substantial number of AIE‐based probes have been designed, synthesized, and applied to various fields to fulfill diverse detection tasks. According to numerous experiments, AIE probes are more practical than traditional fluorescent probes, especially when used in bioassays. To bridge bioimaging and materials engineering, this review provides a comprehensive understanding of the development of AIE bioprobes. It begins with a summary of mechanisms of the AIE phenomenon. Then, the strategies to realize accurate detection using AIE probes are discussed. In addition, typical examples of AIE‐active materials applied in diagnosis, treatment, and nanocarrier tracking are presented. In addition, some challenges are put forward to inspire more ideas in the promising field of AIE‐active materials.</jats:p> |
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| author | Guo, Meichen, Song, Hang, Li, Kai, Ma, Minchao, Liu, Yang, Fu, Qiang, He, Zhonggui |
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| description | <jats:title>Abstract</jats:title><jats:p>Fluorescence imaging is a promising visualization tool and possesses the advantages of in situ response and facile operation; thus, it is widely exploited for bioassays. However, traditional fluorophores suffer from concentration limits because they are always quenched when they aggregate, which impedes applications, especially for trace analysis and real‐time monitoring. Recently, novel molecules with aggregation‐induced emission (AIE) characteristics were developed to solve the problems encountered when using traditional organic dyes, because these new molecules exhibit weak or even no fluorescence when they are in free movement states but emit intensely upon the restriction of intramolecular motions. Inspired by the excellent performances of AIE molecules, a substantial number of AIE‐based probes have been designed, synthesized, and applied to various fields to fulfill diverse detection tasks. According to numerous experiments, AIE probes are more practical than traditional fluorescent probes, especially when used in bioassays. To bridge bioimaging and materials engineering, this review provides a comprehensive understanding of the development of AIE bioprobes. It begins with a summary of mechanisms of the AIE phenomenon. Then, the strategies to realize accurate detection using AIE probes are discussed. In addition, typical examples of AIE‐active materials applied in diagnosis, treatment, and nanocarrier tracking are presented. In addition, some challenges are put forward to inspire more ideas in the promising field of AIE‐active materials.</jats:p> |
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| spelling | Guo, Meichen Song, Hang Li, Kai Ma, Minchao Liu, Yang Fu, Qiang He, Zhonggui 0198-6325 1098-1128 Wiley Drug Discovery Pharmacology Molecular Medicine http://dx.doi.org/10.1002/med.21595 <jats:title>Abstract</jats:title><jats:p>Fluorescence imaging is a promising visualization tool and possesses the advantages of in situ response and facile operation; thus, it is widely exploited for bioassays. However, traditional fluorophores suffer from concentration limits because they are always quenched when they aggregate, which impedes applications, especially for trace analysis and real‐time monitoring. Recently, novel molecules with aggregation‐induced emission (AIE) characteristics were developed to solve the problems encountered when using traditional organic dyes, because these new molecules exhibit weak or even no fluorescence when they are in free movement states but emit intensely upon the restriction of intramolecular motions. Inspired by the excellent performances of AIE molecules, a substantial number of AIE‐based probes have been designed, synthesized, and applied to various fields to fulfill diverse detection tasks. According to numerous experiments, AIE probes are more practical than traditional fluorescent probes, especially when used in bioassays. To bridge bioimaging and materials engineering, this review provides a comprehensive understanding of the development of AIE bioprobes. It begins with a summary of mechanisms of the AIE phenomenon. Then, the strategies to realize accurate detection using AIE probes are discussed. In addition, typical examples of AIE‐active materials applied in diagnosis, treatment, and nanocarrier tracking are presented. In addition, some challenges are put forward to inspire more ideas in the promising field of AIE‐active materials.</jats:p> A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on Medicinal Research Reviews |
| spellingShingle | Guo, Meichen, Song, Hang, Li, Kai, Ma, Minchao, Liu, Yang, Fu, Qiang, He, Zhonggui, Medicinal Research Reviews, A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on, Drug Discovery, Pharmacology, Molecular Medicine |
| title | A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_full | A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_fullStr | A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_full_unstemmed | A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_short | A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| title_sort | a new approach to developing diagnostics and therapeutics: aggregation‐induced emission‐based fluorescence turn‐on |
| title_unstemmed | A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on |
| topic | Drug Discovery, Pharmacology, Molecular Medicine |
| url | http://dx.doi.org/10.1002/med.21595 |