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CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway
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| Zeitschriftentitel: | Molecular Carcinogenesis |
|---|---|
| Personen und Körperschaften: | , , , , , , , , |
| In: | Molecular Carcinogenesis, 55, 2016, 11, S. 1688-1699 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Wang, Qi Tang, Yong Yu, Hongjing Yin, Qiaoyun Li, Mengdi Shi, Lijun Zhang, Wei Li, Danrong Li, Li Wang, Qi Tang, Yong Yu, Hongjing Yin, Qiaoyun Li, Mengdi Shi, Lijun Zhang, Wei Li, Danrong Li, Li |
|---|---|
| author |
Wang, Qi Tang, Yong Yu, Hongjing Yin, Qiaoyun Li, Mengdi Shi, Lijun Zhang, Wei Li, Danrong Li, Li |
| spellingShingle |
Wang, Qi Tang, Yong Yu, Hongjing Yin, Qiaoyun Li, Mengdi Shi, Lijun Zhang, Wei Li, Danrong Li, Li Molecular Carcinogenesis CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway Cancer Research Molecular Biology |
| author_sort |
wang, qi |
| spelling |
Wang, Qi Tang, Yong Yu, Hongjing Yin, Qiaoyun Li, Mengdi Shi, Lijun Zhang, Wei Li, Danrong Li, Li 0899-1987 1098-2744 Wiley Cancer Research Molecular Biology http://dx.doi.org/10.1002/mc.22419 <jats:sec><jats:label /><jats:p>CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Previously, our results showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. In this study, we determined that CCL18 expression was up‐regulated in ovarian carcinoma compared with adjacent tissue and was expressed in carcinoma cells in the tumor and not in normal ovarian epithelial cells by laser capture microdissection coupled with real‐time RT‐PCR. Moreover, correlation analysis showed that the CCL18 level was positively correlated with the metastasis of patients with ovarian cancer. Survival analysis also revealed that an increased level of CCL18 was associated with worse survival time in ovarian cancer patients. Over‐expression of CCL18 led to enhanced migration and invasion of the Skov3 ovarian cancer cell line in vitro and in vivo. Finally, proteomics analysis demonstrated that CCL18‐mediated ovarian cancer invasiveness was strongly correlated with the mTORC2 pathway. These findings suggest that the CCL18 chemokine has an important role in chemokine‐mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. © 2015 The Authors. <jats:italic>Molecular Carcinogenesis</jats:italic> published by Wiley Periodicals, Inc.</jats:p></jats:sec> CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway Molecular Carcinogenesis |
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| title |
CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_unstemmed |
CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_full |
CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_fullStr |
CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_full_unstemmed |
CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_short |
CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_sort |
ccl18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mtor signaling pathway |
| topic |
Cancer Research Molecular Biology |
| url |
http://dx.doi.org/10.1002/mc.22419 |
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2016 |
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1688-1699 |
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<jats:sec><jats:label /><jats:p>CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Previously, our results showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. In this study, we determined that CCL18 expression was up‐regulated in ovarian carcinoma compared with adjacent tissue and was expressed in carcinoma cells in the tumor and not in normal ovarian epithelial cells by laser capture microdissection coupled with real‐time RT‐PCR. Moreover, correlation analysis showed that the CCL18 level was positively correlated with the metastasis of patients with ovarian cancer. Survival analysis also revealed that an increased level of CCL18 was associated with worse survival time in ovarian cancer patients. Over‐expression of CCL18 led to enhanced migration and invasion of the Skov3 ovarian cancer cell line in vitro and in vivo. Finally, proteomics analysis demonstrated that CCL18‐mediated ovarian cancer invasiveness was strongly correlated with the mTORC2 pathway. These findings suggest that the CCL18 chemokine has an important role in chemokine‐mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. © 2015 The Authors. <jats:italic>Molecular Carcinogenesis</jats:italic> published by Wiley Periodicals, Inc.</jats:p></jats:sec> |
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| author | Wang, Qi, Tang, Yong, Yu, Hongjing, Yin, Qiaoyun, Li, Mengdi, Shi, Lijun, Zhang, Wei, Li, Danrong, Li, Li |
| author_facet | Wang, Qi, Tang, Yong, Yu, Hongjing, Yin, Qiaoyun, Li, Mengdi, Shi, Lijun, Zhang, Wei, Li, Danrong, Li, Li, Wang, Qi, Tang, Yong, Yu, Hongjing, Yin, Qiaoyun, Li, Mengdi, Shi, Lijun, Zhang, Wei, Li, Danrong, Li, Li |
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| description | <jats:sec><jats:label /><jats:p>CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Previously, our results showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. In this study, we determined that CCL18 expression was up‐regulated in ovarian carcinoma compared with adjacent tissue and was expressed in carcinoma cells in the tumor and not in normal ovarian epithelial cells by laser capture microdissection coupled with real‐time RT‐PCR. Moreover, correlation analysis showed that the CCL18 level was positively correlated with the metastasis of patients with ovarian cancer. Survival analysis also revealed that an increased level of CCL18 was associated with worse survival time in ovarian cancer patients. Over‐expression of CCL18 led to enhanced migration and invasion of the Skov3 ovarian cancer cell line in vitro and in vivo. Finally, proteomics analysis demonstrated that CCL18‐mediated ovarian cancer invasiveness was strongly correlated with the mTORC2 pathway. These findings suggest that the CCL18 chemokine has an important role in chemokine‐mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. © 2015 The Authors. <jats:italic>Molecular Carcinogenesis</jats:italic> published by Wiley Periodicals, Inc.</jats:p></jats:sec> |
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| spelling | Wang, Qi Tang, Yong Yu, Hongjing Yin, Qiaoyun Li, Mengdi Shi, Lijun Zhang, Wei Li, Danrong Li, Li 0899-1987 1098-2744 Wiley Cancer Research Molecular Biology http://dx.doi.org/10.1002/mc.22419 <jats:sec><jats:label /><jats:p>CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Previously, our results showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. In this study, we determined that CCL18 expression was up‐regulated in ovarian carcinoma compared with adjacent tissue and was expressed in carcinoma cells in the tumor and not in normal ovarian epithelial cells by laser capture microdissection coupled with real‐time RT‐PCR. Moreover, correlation analysis showed that the CCL18 level was positively correlated with the metastasis of patients with ovarian cancer. Survival analysis also revealed that an increased level of CCL18 was associated with worse survival time in ovarian cancer patients. Over‐expression of CCL18 led to enhanced migration and invasion of the Skov3 ovarian cancer cell line in vitro and in vivo. Finally, proteomics analysis demonstrated that CCL18‐mediated ovarian cancer invasiveness was strongly correlated with the mTORC2 pathway. These findings suggest that the CCL18 chemokine has an important role in chemokine‐mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. © 2015 The Authors. <jats:italic>Molecular Carcinogenesis</jats:italic> published by Wiley Periodicals, Inc.</jats:p></jats:sec> CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway Molecular Carcinogenesis |
| spellingShingle | Wang, Qi, Tang, Yong, Yu, Hongjing, Yin, Qiaoyun, Li, Mengdi, Shi, Lijun, Zhang, Wei, Li, Danrong, Li, Li, Molecular Carcinogenesis, CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway, Cancer Research, Molecular Biology |
| title | CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_full | CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_fullStr | CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_full_unstemmed | CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_short | CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| title_sort | ccl18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mtor signaling pathway |
| title_unstemmed | CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway |
| topic | Cancer Research, Molecular Biology |
| url | http://dx.doi.org/10.1002/mc.22419 |