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Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells
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| Zeitschriftentitel: | Macromolecular Bioscience |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Macromolecular Bioscience, 15, 2015, 10, S. 1365-1374 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Mancarella, Serena Greco, Valentina Baldassarre, Francesca Vergara, Daniele Maffia, Michele Leporatti, Stefano Mancarella, Serena Greco, Valentina Baldassarre, Francesca Vergara, Daniele Maffia, Michele Leporatti, Stefano |
|---|---|
| author |
Mancarella, Serena Greco, Valentina Baldassarre, Francesca Vergara, Daniele Maffia, Michele Leporatti, Stefano |
| spellingShingle |
Mancarella, Serena Greco, Valentina Baldassarre, Francesca Vergara, Daniele Maffia, Michele Leporatti, Stefano Macromolecular Bioscience Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells Materials Chemistry Polymers and Plastics Biomaterials Bioengineering Biotechnology |
| author_sort |
mancarella, serena |
| spelling |
Mancarella, Serena Greco, Valentina Baldassarre, Francesca Vergara, Daniele Maffia, Michele Leporatti, Stefano 1616-5187 1616-5195 Wiley Materials Chemistry Polymers and Plastics Biomaterials Bioengineering Biotechnology http://dx.doi.org/10.1002/mabi.201500142 <jats:sec><jats:label /><jats:p>The new goal of anticancer agent research is the screening of natural origin drugs with lower systemic adverse effects than synthetic compounds. Here, we focus on curcumin, an important polyphenolic pigment classically used as spice in the Indian cuisine. The molecule has high pleiotropic activities including strong antioxidant and anti‐inflammatory properties. However, its clinical potential is limited due its low solubility and bioavailability. We have developed a layer by layer functionalization of Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles (nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub>) by coating biodegradable polyelectrolyte multilayers such as Dextran (DXS) and Poly(<jats:sc>l</jats:sc>‐lysine) (PLL). Physico‐chemical studies were performed to obtain a high upload of curcumin in Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles. Nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> were then tested against an ovarian cancer cell line, SKOV‐3, to demonstrate their therapeutic efficacy. <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mabi201500142-gra-0001.png" xlink:title="mabi201500142-gra-0001" /></jats:p></jats:sec> Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells Macromolecular Bioscience |
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| title |
Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_unstemmed |
Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_full |
Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_fullStr |
Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_full_unstemmed |
Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_short |
Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_sort |
polymer‐coated magnetic nanoparticles for curcumin delivery to cancer cells |
| topic |
Materials Chemistry Polymers and Plastics Biomaterials Bioengineering Biotechnology |
| url |
http://dx.doi.org/10.1002/mabi.201500142 |
| publishDate |
2015 |
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1365-1374 |
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<jats:sec><jats:label /><jats:p>The new goal of anticancer agent research is the screening of natural origin drugs with lower systemic adverse effects than synthetic compounds. Here, we focus on curcumin, an important polyphenolic pigment classically used as spice in the Indian cuisine. The molecule has high pleiotropic activities including strong antioxidant and anti‐inflammatory properties. However, its clinical potential is limited due its low solubility and bioavailability. We have developed a layer by layer functionalization of Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles (nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub>) by coating biodegradable polyelectrolyte multilayers such as Dextran (DXS) and Poly(<jats:sc>l</jats:sc>‐lysine) (PLL). Physico‐chemical studies were performed to obtain a high upload of curcumin in Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles. Nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> were then tested against an ovarian cancer cell line, SKOV‐3, to demonstrate their therapeutic efficacy. <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mabi201500142-gra-0001.png" xlink:title="mabi201500142-gra-0001" /></jats:p></jats:sec> |
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| author | Mancarella, Serena, Greco, Valentina, Baldassarre, Francesca, Vergara, Daniele, Maffia, Michele, Leporatti, Stefano |
| author_facet | Mancarella, Serena, Greco, Valentina, Baldassarre, Francesca, Vergara, Daniele, Maffia, Michele, Leporatti, Stefano, Mancarella, Serena, Greco, Valentina, Baldassarre, Francesca, Vergara, Daniele, Maffia, Michele, Leporatti, Stefano |
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| description | <jats:sec><jats:label /><jats:p>The new goal of anticancer agent research is the screening of natural origin drugs with lower systemic adverse effects than synthetic compounds. Here, we focus on curcumin, an important polyphenolic pigment classically used as spice in the Indian cuisine. The molecule has high pleiotropic activities including strong antioxidant and anti‐inflammatory properties. However, its clinical potential is limited due its low solubility and bioavailability. We have developed a layer by layer functionalization of Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles (nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub>) by coating biodegradable polyelectrolyte multilayers such as Dextran (DXS) and Poly(<jats:sc>l</jats:sc>‐lysine) (PLL). Physico‐chemical studies were performed to obtain a high upload of curcumin in Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles. Nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> were then tested against an ovarian cancer cell line, SKOV‐3, to demonstrate their therapeutic efficacy. <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mabi201500142-gra-0001.png" xlink:title="mabi201500142-gra-0001" /></jats:p></jats:sec> |
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| spelling | Mancarella, Serena Greco, Valentina Baldassarre, Francesca Vergara, Daniele Maffia, Michele Leporatti, Stefano 1616-5187 1616-5195 Wiley Materials Chemistry Polymers and Plastics Biomaterials Bioengineering Biotechnology http://dx.doi.org/10.1002/mabi.201500142 <jats:sec><jats:label /><jats:p>The new goal of anticancer agent research is the screening of natural origin drugs with lower systemic adverse effects than synthetic compounds. Here, we focus on curcumin, an important polyphenolic pigment classically used as spice in the Indian cuisine. The molecule has high pleiotropic activities including strong antioxidant and anti‐inflammatory properties. However, its clinical potential is limited due its low solubility and bioavailability. We have developed a layer by layer functionalization of Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles (nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub>) by coating biodegradable polyelectrolyte multilayers such as Dextran (DXS) and Poly(<jats:sc>l</jats:sc>‐lysine) (PLL). Physico‐chemical studies were performed to obtain a high upload of curcumin in Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> nanoparticles. Nano‐Fe<jats:sub>3</jats:sub>O<jats:sub>4</jats:sub> were then tested against an ovarian cancer cell line, SKOV‐3, to demonstrate their therapeutic efficacy. <jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/mabi201500142-gra-0001.png" xlink:title="mabi201500142-gra-0001" /></jats:p></jats:sec> Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells Macromolecular Bioscience |
| spellingShingle | Mancarella, Serena, Greco, Valentina, Baldassarre, Francesca, Vergara, Daniele, Maffia, Michele, Leporatti, Stefano, Macromolecular Bioscience, Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells, Materials Chemistry, Polymers and Plastics, Biomaterials, Bioengineering, Biotechnology |
| title | Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_full | Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_fullStr | Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_full_unstemmed | Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_short | Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| title_sort | polymer‐coated magnetic nanoparticles for curcumin delivery to cancer cells |
| title_unstemmed | Polymer‐Coated Magnetic Nanoparticles for Curcumin Delivery to Cancer Cells |
| topic | Materials Chemistry, Polymers and Plastics, Biomaterials, Bioengineering, Biotechnology |
| url | http://dx.doi.org/10.1002/mabi.201500142 |