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Sarcopenia in Chronic Liver Disease: Impact on Outcomes
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| Zeitschriftentitel: | Liver Transplantation |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Liver Transplantation, 25, 2019, 9, S. 1422-1438 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Ovid Technologies (Wolters Kluwer Health)
|
| Schlagwörter: |
| author_facet |
Ooi, Poh Hwa Hager, Amber Mazurak, Vera C. Dajani, Khaled Bhargava, Ravi Gilmour, Susan M. Mager, Diana R. Ooi, Poh Hwa Hager, Amber Mazurak, Vera C. Dajani, Khaled Bhargava, Ravi Gilmour, Susan M. Mager, Diana R. |
|---|---|
| author |
Ooi, Poh Hwa Hager, Amber Mazurak, Vera C. Dajani, Khaled Bhargava, Ravi Gilmour, Susan M. Mager, Diana R. |
| spellingShingle |
Ooi, Poh Hwa Hager, Amber Mazurak, Vera C. Dajani, Khaled Bhargava, Ravi Gilmour, Susan M. Mager, Diana R. Liver Transplantation Sarcopenia in Chronic Liver Disease: Impact on Outcomes Transplantation Hepatology Surgery |
| author_sort |
ooi, poh hwa |
| spelling |
Ooi, Poh Hwa Hager, Amber Mazurak, Vera C. Dajani, Khaled Bhargava, Ravi Gilmour, Susan M. Mager, Diana R. 1527-6465 1527-6473 Ovid Technologies (Wolters Kluwer Health) Transplantation Hepatology Surgery http://dx.doi.org/10.1002/lt.25591 <jats:p>Malnutrition is a common complication in patients with end‐stage liver disease (ESLD) awaiting liver transplantation (LT). Malnutrition and sarcopenia overlap in etiology and outcomes, with sarcopenia being defined as reduced skeletal muscle mass and muscle function. The purpose of this review was to identify the prevalence of sarcopenia with and without obesity in adults and children with ESLD and to assess the methodological considerations in sarcopenia diagnosis and the association of sarcopenia with pre‐ and post‐LT outcomes. A total of 38 articles (35 adult and 3 pediatric articles) retrieved from PubMed or Web of Science databases were included. In adults, the prevalence rates of pre‐LT sarcopenia, pre‐LT sarcopenic obesity (SO), post‐LT sarcopenia, and post‐LT SO were 14%‐78%, 2%‐42%, 30%‐100%, and 88%, respectively. Only 2 adult studies assessed muscle function in patients diagnosed with sarcopenia. The presence of pre‐LT sarcopenia is associated with higher wait‐list mortality, greater postoperative mortality, higher infection risk and postoperative complications, longer intensive care unit (ICU) stay, and ventilator dependency. The emerging pediatric data suggest that sarcopenia is prevalent in pre‐ and post‐LT periods. In 1 pediatric study, sarcopenia was associated with poor growth, longer perioperative length of stay (total/ICU) and ventilator dependency, and increased rehospitalization in children after LT. In conclusion, there is a high prevalence of sarcopenia in adults and children with ESLD. Sarcopenia is associated with adverse clinical outcomes. The present review is limited by heterogeneity in the definition of sarcopenia and in the methodological approaches in assessing sarcopenia. Future studies are needed to standardize the sarcopenia diagnosis and muscle function assessment, particularly in the pediatric population, to enable early identification and treatment of sarcopenia in adults and children with ESLD.</jats:p> Sarcopenia in Chronic Liver Disease: Impact on Outcomes Liver Transplantation |
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| title |
Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_unstemmed |
Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_full |
Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_fullStr |
Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_full_unstemmed |
Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_short |
Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_sort |
sarcopenia in chronic liver disease: impact on outcomes |
| topic |
Transplantation Hepatology Surgery |
| url |
http://dx.doi.org/10.1002/lt.25591 |
| publishDate |
2019 |
| physical |
1422-1438 |
| description |
<jats:p>Malnutrition is a common complication in patients with end‐stage liver disease (ESLD) awaiting liver transplantation (LT). Malnutrition and sarcopenia overlap in etiology and outcomes, with sarcopenia being defined as reduced skeletal muscle mass and muscle function. The purpose of this review was to identify the prevalence of sarcopenia with and without obesity in adults and children with ESLD and to assess the methodological considerations in sarcopenia diagnosis and the association of sarcopenia with pre‐ and post‐LT outcomes. A total of 38 articles (35 adult and 3 pediatric articles) retrieved from PubMed or Web of Science databases were included. In adults, the prevalence rates of pre‐LT sarcopenia, pre‐LT sarcopenic obesity (SO), post‐LT sarcopenia, and post‐LT SO were 14%‐78%, 2%‐42%, 30%‐100%, and 88%, respectively. Only 2 adult studies assessed muscle function in patients diagnosed with sarcopenia. The presence of pre‐LT sarcopenia is associated with higher wait‐list mortality, greater postoperative mortality, higher infection risk and postoperative complications, longer intensive care unit (ICU) stay, and ventilator dependency. The emerging pediatric data suggest that sarcopenia is prevalent in pre‐ and post‐LT periods. In 1 pediatric study, sarcopenia was associated with poor growth, longer perioperative length of stay (total/ICU) and ventilator dependency, and increased rehospitalization in children after LT. In conclusion, there is a high prevalence of sarcopenia in adults and children with ESLD. Sarcopenia is associated with adverse clinical outcomes. The present review is limited by heterogeneity in the definition of sarcopenia and in the methodological approaches in assessing sarcopenia. Future studies are needed to standardize the sarcopenia diagnosis and muscle function assessment, particularly in the pediatric population, to enable early identification and treatment of sarcopenia in adults and children with ESLD.</jats:p> |
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| author | Ooi, Poh Hwa, Hager, Amber, Mazurak, Vera C., Dajani, Khaled, Bhargava, Ravi, Gilmour, Susan M., Mager, Diana R. |
| author_facet | Ooi, Poh Hwa, Hager, Amber, Mazurak, Vera C., Dajani, Khaled, Bhargava, Ravi, Gilmour, Susan M., Mager, Diana R., Ooi, Poh Hwa, Hager, Amber, Mazurak, Vera C., Dajani, Khaled, Bhargava, Ravi, Gilmour, Susan M., Mager, Diana R. |
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| description | <jats:p>Malnutrition is a common complication in patients with end‐stage liver disease (ESLD) awaiting liver transplantation (LT). Malnutrition and sarcopenia overlap in etiology and outcomes, with sarcopenia being defined as reduced skeletal muscle mass and muscle function. The purpose of this review was to identify the prevalence of sarcopenia with and without obesity in adults and children with ESLD and to assess the methodological considerations in sarcopenia diagnosis and the association of sarcopenia with pre‐ and post‐LT outcomes. A total of 38 articles (35 adult and 3 pediatric articles) retrieved from PubMed or Web of Science databases were included. In adults, the prevalence rates of pre‐LT sarcopenia, pre‐LT sarcopenic obesity (SO), post‐LT sarcopenia, and post‐LT SO were 14%‐78%, 2%‐42%, 30%‐100%, and 88%, respectively. Only 2 adult studies assessed muscle function in patients diagnosed with sarcopenia. The presence of pre‐LT sarcopenia is associated with higher wait‐list mortality, greater postoperative mortality, higher infection risk and postoperative complications, longer intensive care unit (ICU) stay, and ventilator dependency. The emerging pediatric data suggest that sarcopenia is prevalent in pre‐ and post‐LT periods. In 1 pediatric study, sarcopenia was associated with poor growth, longer perioperative length of stay (total/ICU) and ventilator dependency, and increased rehospitalization in children after LT. In conclusion, there is a high prevalence of sarcopenia in adults and children with ESLD. Sarcopenia is associated with adverse clinical outcomes. The present review is limited by heterogeneity in the definition of sarcopenia and in the methodological approaches in assessing sarcopenia. Future studies are needed to standardize the sarcopenia diagnosis and muscle function assessment, particularly in the pediatric population, to enable early identification and treatment of sarcopenia in adults and children with ESLD.</jats:p> |
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| spelling | Ooi, Poh Hwa Hager, Amber Mazurak, Vera C. Dajani, Khaled Bhargava, Ravi Gilmour, Susan M. Mager, Diana R. 1527-6465 1527-6473 Ovid Technologies (Wolters Kluwer Health) Transplantation Hepatology Surgery http://dx.doi.org/10.1002/lt.25591 <jats:p>Malnutrition is a common complication in patients with end‐stage liver disease (ESLD) awaiting liver transplantation (LT). Malnutrition and sarcopenia overlap in etiology and outcomes, with sarcopenia being defined as reduced skeletal muscle mass and muscle function. The purpose of this review was to identify the prevalence of sarcopenia with and without obesity in adults and children with ESLD and to assess the methodological considerations in sarcopenia diagnosis and the association of sarcopenia with pre‐ and post‐LT outcomes. A total of 38 articles (35 adult and 3 pediatric articles) retrieved from PubMed or Web of Science databases were included. In adults, the prevalence rates of pre‐LT sarcopenia, pre‐LT sarcopenic obesity (SO), post‐LT sarcopenia, and post‐LT SO were 14%‐78%, 2%‐42%, 30%‐100%, and 88%, respectively. Only 2 adult studies assessed muscle function in patients diagnosed with sarcopenia. The presence of pre‐LT sarcopenia is associated with higher wait‐list mortality, greater postoperative mortality, higher infection risk and postoperative complications, longer intensive care unit (ICU) stay, and ventilator dependency. The emerging pediatric data suggest that sarcopenia is prevalent in pre‐ and post‐LT periods. In 1 pediatric study, sarcopenia was associated with poor growth, longer perioperative length of stay (total/ICU) and ventilator dependency, and increased rehospitalization in children after LT. In conclusion, there is a high prevalence of sarcopenia in adults and children with ESLD. Sarcopenia is associated with adverse clinical outcomes. The present review is limited by heterogeneity in the definition of sarcopenia and in the methodological approaches in assessing sarcopenia. Future studies are needed to standardize the sarcopenia diagnosis and muscle function assessment, particularly in the pediatric population, to enable early identification and treatment of sarcopenia in adults and children with ESLD.</jats:p> Sarcopenia in Chronic Liver Disease: Impact on Outcomes Liver Transplantation |
| spellingShingle | Ooi, Poh Hwa, Hager, Amber, Mazurak, Vera C., Dajani, Khaled, Bhargava, Ravi, Gilmour, Susan M., Mager, Diana R., Liver Transplantation, Sarcopenia in Chronic Liver Disease: Impact on Outcomes, Transplantation, Hepatology, Surgery |
| title | Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_full | Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_fullStr | Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_full_unstemmed | Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_short | Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| title_sort | sarcopenia in chronic liver disease: impact on outcomes |
| title_unstemmed | Sarcopenia in Chronic Liver Disease: Impact on Outcomes |
| topic | Transplantation, Hepatology, Surgery |
| url | http://dx.doi.org/10.1002/lt.25591 |