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Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photo...
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| Zeitschriftentitel: | Journal of Separation Science |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Separation Science, 36, 2013, 3, S. 492-502 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Zhao, Haiyu Wu, Xu Wang, Hongjie Gao, Bo Yang, Jian Si, Nan Bian, Baolin Zhao, Haiyu Wu, Xu Wang, Hongjie Gao, Bo Yang, Jian Si, Nan Bian, Baolin |
|---|---|
| author |
Zhao, Haiyu Wu, Xu Wang, Hongjie Gao, Bo Yang, Jian Si, Nan Bian, Baolin |
| spellingShingle |
Zhao, Haiyu Wu, Xu Wang, Hongjie Gao, Bo Yang, Jian Si, Nan Bian, Baolin Journal of Separation Science Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections Filtration and Separation Analytical Chemistry |
| author_sort |
zhao, haiyu |
| spelling |
Zhao, Haiyu Wu, Xu Wang, Hongjie Gao, Bo Yang, Jian Si, Nan Bian, Baolin 1615-9306 1615-9314 Wiley Filtration and Separation Analytical Chemistry http://dx.doi.org/10.1002/jssc.201200762 <jats:p>Cinobufacini injection, prepared from the skin of <jats:italic><jats:styled-content style="fixed-case">B</jats:styled-content>ufo bufo gargarizans</jats:italic> <jats:styled-content style="fixed-case">C</jats:styled-content>antor, has presented its significant effects on the treatment of hepatitis and various cancers in the clinic. However, as an unclear complex chemical system, the optimization of its quality control markers has been a long‐term challenge. In present study, a feasible strategy integrated markers screening, determination, and statistical analysis was efficiently proposed, especially for the undefined <jats:styled-content style="fixed-case">C</jats:styled-content>hinese medicine injections. First, rapid separation <jats:styled-content style="fixed-case">LC</jats:styled-content>‐quadrupole‐<jats:styled-content style="fixed-case">TOF</jats:styled-content>‐<jats:styled-content style="fixed-case">MS</jats:styled-content> method was applied in the identification of 19 major compounds in the cinobufacini injection for the first time. Further, nine high‐level contents active compounds were selected as quality control markers for the quantification analysis. An acceptable and validated determination method was established in 17 batches of cinobufacini injection by <jats:styled-content style="fixed-case">HPLC</jats:styled-content>‐photodiode array detection method, including linear regression relationship (<jats:italic>r</jats:italic><jats:sup>2</jats:sup>, 0.9996–1), precisions (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.02–1.35%), repeatability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.05–1.97%), stability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.1–3.85%), and recovery (95.88–104.89%). Each analyte was detected at its maximum ultraviolet spectra wavelength. Finally, based on the quantification results, principal component analysis was performed on the quality assessment of cinobufacini injections. This three‐step strategy provides a newly feasible solution for the quality control of Chinese medicine injections.</jats:p> Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and <scp>HPLC</scp>‐photodiode array detection, a feasible strategy for the quality control of <scp>C</scp>hinese medicine injections Journal of Separation Science |
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Chemie und Pharmazie |
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Wiley, 2013 |
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zhao2013qualitativeandquantitativeanalysisofcinobufaciniinjectionusingrapidseparationliquidchromatographycoupledwithquadrupoletimeofflightmassspectrometryandhplcphotodiodearraydetectionafeasiblestrategyforthequalitycontrolofchinesemedicineinjections |
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2013 |
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Journal of Separation Science |
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49 |
| title |
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_unstemmed |
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_full |
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_fullStr |
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_full_unstemmed |
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_short |
Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_sort |
qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and <scp>hplc</scp>‐photodiode array detection, a feasible strategy for the quality control of <scp>c</scp>hinese medicine injections |
| topic |
Filtration and Separation Analytical Chemistry |
| url |
http://dx.doi.org/10.1002/jssc.201200762 |
| publishDate |
2013 |
| physical |
492-502 |
| description |
<jats:p>Cinobufacini injection, prepared from the skin of <jats:italic><jats:styled-content style="fixed-case">B</jats:styled-content>ufo bufo gargarizans</jats:italic> <jats:styled-content style="fixed-case">C</jats:styled-content>antor, has presented its significant effects on the treatment of hepatitis and various cancers in the clinic. However, as an unclear complex chemical system, the optimization of its quality control markers has been a long‐term challenge. In present study, a feasible strategy integrated markers screening, determination, and statistical analysis was efficiently proposed, especially for the undefined <jats:styled-content style="fixed-case">C</jats:styled-content>hinese medicine injections. First, rapid separation <jats:styled-content style="fixed-case">LC</jats:styled-content>‐quadrupole‐<jats:styled-content style="fixed-case">TOF</jats:styled-content>‐<jats:styled-content style="fixed-case">MS</jats:styled-content> method was applied in the identification of 19 major compounds in the cinobufacini injection for the first time. Further, nine high‐level contents active compounds were selected as quality control markers for the quantification analysis. An acceptable and validated determination method was established in 17 batches of cinobufacini injection by <jats:styled-content style="fixed-case">HPLC</jats:styled-content>‐photodiode array detection method, including linear regression relationship (<jats:italic>r</jats:italic><jats:sup>2</jats:sup>, 0.9996–1), precisions (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.02–1.35%), repeatability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.05–1.97%), stability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.1–3.85%), and recovery (95.88–104.89%). Each analyte was detected at its maximum ultraviolet spectra wavelength. Finally, based on the quantification results, principal component analysis was performed on the quality assessment of cinobufacini injections. This three‐step strategy provides a newly feasible solution for the quality control of Chinese medicine injections.</jats:p> |
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| description | <jats:p>Cinobufacini injection, prepared from the skin of <jats:italic><jats:styled-content style="fixed-case">B</jats:styled-content>ufo bufo gargarizans</jats:italic> <jats:styled-content style="fixed-case">C</jats:styled-content>antor, has presented its significant effects on the treatment of hepatitis and various cancers in the clinic. However, as an unclear complex chemical system, the optimization of its quality control markers has been a long‐term challenge. In present study, a feasible strategy integrated markers screening, determination, and statistical analysis was efficiently proposed, especially for the undefined <jats:styled-content style="fixed-case">C</jats:styled-content>hinese medicine injections. First, rapid separation <jats:styled-content style="fixed-case">LC</jats:styled-content>‐quadrupole‐<jats:styled-content style="fixed-case">TOF</jats:styled-content>‐<jats:styled-content style="fixed-case">MS</jats:styled-content> method was applied in the identification of 19 major compounds in the cinobufacini injection for the first time. Further, nine high‐level contents active compounds were selected as quality control markers for the quantification analysis. An acceptable and validated determination method was established in 17 batches of cinobufacini injection by <jats:styled-content style="fixed-case">HPLC</jats:styled-content>‐photodiode array detection method, including linear regression relationship (<jats:italic>r</jats:italic><jats:sup>2</jats:sup>, 0.9996–1), precisions (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.02–1.35%), repeatability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.05–1.97%), stability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.1–3.85%), and recovery (95.88–104.89%). Each analyte was detected at its maximum ultraviolet spectra wavelength. Finally, based on the quantification results, principal component analysis was performed on the quality assessment of cinobufacini injections. This three‐step strategy provides a newly feasible solution for the quality control of Chinese medicine injections.</jats:p> |
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| spelling | Zhao, Haiyu Wu, Xu Wang, Hongjie Gao, Bo Yang, Jian Si, Nan Bian, Baolin 1615-9306 1615-9314 Wiley Filtration and Separation Analytical Chemistry http://dx.doi.org/10.1002/jssc.201200762 <jats:p>Cinobufacini injection, prepared from the skin of <jats:italic><jats:styled-content style="fixed-case">B</jats:styled-content>ufo bufo gargarizans</jats:italic> <jats:styled-content style="fixed-case">C</jats:styled-content>antor, has presented its significant effects on the treatment of hepatitis and various cancers in the clinic. However, as an unclear complex chemical system, the optimization of its quality control markers has been a long‐term challenge. In present study, a feasible strategy integrated markers screening, determination, and statistical analysis was efficiently proposed, especially for the undefined <jats:styled-content style="fixed-case">C</jats:styled-content>hinese medicine injections. First, rapid separation <jats:styled-content style="fixed-case">LC</jats:styled-content>‐quadrupole‐<jats:styled-content style="fixed-case">TOF</jats:styled-content>‐<jats:styled-content style="fixed-case">MS</jats:styled-content> method was applied in the identification of 19 major compounds in the cinobufacini injection for the first time. Further, nine high‐level contents active compounds were selected as quality control markers for the quantification analysis. An acceptable and validated determination method was established in 17 batches of cinobufacini injection by <jats:styled-content style="fixed-case">HPLC</jats:styled-content>‐photodiode array detection method, including linear regression relationship (<jats:italic>r</jats:italic><jats:sup>2</jats:sup>, 0.9996–1), precisions (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.02–1.35%), repeatability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.05–1.97%), stability (<jats:styled-content style="fixed-case">RSD</jats:styled-content>, 0.1–3.85%), and recovery (95.88–104.89%). Each analyte was detected at its maximum ultraviolet spectra wavelength. Finally, based on the quantification results, principal component analysis was performed on the quality assessment of cinobufacini injections. This three‐step strategy provides a newly feasible solution for the quality control of Chinese medicine injections.</jats:p> Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and <scp>HPLC</scp>‐photodiode array detection, a feasible strategy for the quality control of <scp>C</scp>hinese medicine injections Journal of Separation Science |
| spellingShingle | Zhao, Haiyu, Wu, Xu, Wang, Hongjie, Gao, Bo, Yang, Jian, Si, Nan, Bian, Baolin, Journal of Separation Science, Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections, Filtration and Separation, Analytical Chemistry |
| title | Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_full | Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_fullStr | Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_full_unstemmed | Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_short | Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| title_sort | qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and <scp>hplc</scp>‐photodiode array detection, a feasible strategy for the quality control of <scp>c</scp>hinese medicine injections |
| title_unstemmed | Qualitative and quantitative analysis of cinobufacini injection using rapid separation liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry and HPLC‐photodiode array detection, a feasible strategy for the quality control of Chinese medicine injections |
| topic | Filtration and Separation, Analytical Chemistry |
| url | http://dx.doi.org/10.1002/jssc.201200762 |