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Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast...

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Zeitschriftentitel: Journal of Surgical Oncology
Personen und Körperschaften: Susnik, Barbara, Schneider, Lisa, Swenson, Karen K., Krueger, Janet, Braatz, Christina, Lillemoe, Tamera, Tsai, Michaela, DeFor, Todd E., Knaack, Monica, Rueth, Natasha
In: Journal of Surgical Oncology, 118, 2018, 1, S. 221-227
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Oncology
General Medicine
Surgery
author_facet Susnik, Barbara
Schneider, Lisa
Swenson, Karen K.
Krueger, Janet
Braatz, Christina
Lillemoe, Tamera
Tsai, Michaela
DeFor, Todd E.
Knaack, Monica
Rueth, Natasha
Susnik, Barbara
Schneider, Lisa
Swenson, Karen K.
Krueger, Janet
Braatz, Christina
Lillemoe, Tamera
Tsai, Michaela
DeFor, Todd E.
Knaack, Monica
Rueth, Natasha
author Susnik, Barbara
Schneider, Lisa
Swenson, Karen K.
Krueger, Janet
Braatz, Christina
Lillemoe, Tamera
Tsai, Michaela
DeFor, Todd E.
Knaack, Monica
Rueth, Natasha
spellingShingle Susnik, Barbara
Schneider, Lisa
Swenson, Karen K.
Krueger, Janet
Braatz, Christina
Lillemoe, Tamera
Tsai, Michaela
DeFor, Todd E.
Knaack, Monica
Rueth, Natasha
Journal of Surgical Oncology
Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
Oncology
General Medicine
Surgery
author_sort susnik, barbara
spelling Susnik, Barbara Schneider, Lisa Swenson, Karen K. Krueger, Janet Braatz, Christina Lillemoe, Tamera Tsai, Michaela DeFor, Todd E. Knaack, Monica Rueth, Natasha 0022-4790 1096-9098 Wiley Oncology General Medicine Surgery http://dx.doi.org/10.1002/jso.25130 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Preoperative breast magnetic resonance imaging (B‐MRI) staging in newly diagnosed breast cancer increases detection of synchronous contralateral findings, but may result in false‐positive outcomes. This study objective was to identify women more likely of having mammographically occult, MRI detected contralateral breast cancer (CBC).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a retrospective review of patients who had preoperative B‐MRI prior to surgery from 2010 to 2015 and collected patient imaging and clinicopathologic data. Multivariate logistic regression was used to identify predictors of CBC.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>MRI resulted in contralateral findings in 201 of 1894 patients (10.6%). Overall 3.2% (60 of 1894) had synchronous CBC detected on B‐MRI. The majority of CBCs (n = 60) were stage 0 or IA (85.0%), hormone receptor positive (94.9%), human epidermal growth factor receptor 2 (HER2/neu) negative (89.7%), and low/intermediate pathological grade (87.2%). Women more likely to have CBC were older (<jats:italic>P</jats:italic> &lt; .001), had lobular index cancer (<jats:italic>P = </jats:italic>.03), and estrogen receptor (ER)+ (<jats:italic>P </jats:italic>= .027) or progesterone receptor (PR)+ (<jats:italic>P</jats:italic> = .002) tumors. On multivariate analysis (receiver operating characteristic curve area = 0.75), PR + status (<jats:italic>P</jats:italic> = .022), and older age (<jats:italic>P</jats:italic> = .004) were predictive of CBC.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Preoperative MRI is most effective in detecting early stage, hormone receptor‐positive CBC in older women.</jats:p></jats:sec> Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer? Journal of Surgical Oncology
doi_str_mv 10.1002/jso.25130
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publisher Wiley
recordtype ai
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series Journal of Surgical Oncology
source_id 49
title Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_unstemmed Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_full Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_fullStr Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_full_unstemmed Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_short Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_sort predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: can we target women more likely to have contralateral breast cancer?
topic Oncology
General Medicine
Surgery
url http://dx.doi.org/10.1002/jso.25130
publishDate 2018
physical 221-227
description <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Preoperative breast magnetic resonance imaging (B‐MRI) staging in newly diagnosed breast cancer increases detection of synchronous contralateral findings, but may result in false‐positive outcomes. This study objective was to identify women more likely of having mammographically occult, MRI detected contralateral breast cancer (CBC).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a retrospective review of patients who had preoperative B‐MRI prior to surgery from 2010 to 2015 and collected patient imaging and clinicopathologic data. Multivariate logistic regression was used to identify predictors of CBC.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>MRI resulted in contralateral findings in 201 of 1894 patients (10.6%). Overall 3.2% (60 of 1894) had synchronous CBC detected on B‐MRI. The majority of CBCs (n = 60) were stage 0 or IA (85.0%), hormone receptor positive (94.9%), human epidermal growth factor receptor 2 (HER2/neu) negative (89.7%), and low/intermediate pathological grade (87.2%). Women more likely to have CBC were older (<jats:italic>P</jats:italic> &lt; .001), had lobular index cancer (<jats:italic>P = </jats:italic>.03), and estrogen receptor (ER)+ (<jats:italic>P </jats:italic>= .027) or progesterone receptor (PR)+ (<jats:italic>P</jats:italic> = .002) tumors. On multivariate analysis (receiver operating characteristic curve area = 0.75), PR + status (<jats:italic>P</jats:italic> = .022), and older age (<jats:italic>P</jats:italic> = .004) were predictive of CBC.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Preoperative MRI is most effective in detecting early stage, hormone receptor‐positive CBC in older women.</jats:p></jats:sec>
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author Susnik, Barbara, Schneider, Lisa, Swenson, Karen K., Krueger, Janet, Braatz, Christina, Lillemoe, Tamera, Tsai, Michaela, DeFor, Todd E., Knaack, Monica, Rueth, Natasha
author_facet Susnik, Barbara, Schneider, Lisa, Swenson, Karen K., Krueger, Janet, Braatz, Christina, Lillemoe, Tamera, Tsai, Michaela, DeFor, Todd E., Knaack, Monica, Rueth, Natasha, Susnik, Barbara, Schneider, Lisa, Swenson, Karen K., Krueger, Janet, Braatz, Christina, Lillemoe, Tamera, Tsai, Michaela, DeFor, Todd E., Knaack, Monica, Rueth, Natasha
author_sort susnik, barbara
container_issue 1
container_start_page 221
container_title Journal of Surgical Oncology
container_volume 118
description <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Preoperative breast magnetic resonance imaging (B‐MRI) staging in newly diagnosed breast cancer increases detection of synchronous contralateral findings, but may result in false‐positive outcomes. This study objective was to identify women more likely of having mammographically occult, MRI detected contralateral breast cancer (CBC).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a retrospective review of patients who had preoperative B‐MRI prior to surgery from 2010 to 2015 and collected patient imaging and clinicopathologic data. Multivariate logistic regression was used to identify predictors of CBC.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>MRI resulted in contralateral findings in 201 of 1894 patients (10.6%). Overall 3.2% (60 of 1894) had synchronous CBC detected on B‐MRI. The majority of CBCs (n = 60) were stage 0 or IA (85.0%), hormone receptor positive (94.9%), human epidermal growth factor receptor 2 (HER2/neu) negative (89.7%), and low/intermediate pathological grade (87.2%). Women more likely to have CBC were older (<jats:italic>P</jats:italic> &lt; .001), had lobular index cancer (<jats:italic>P = </jats:italic>.03), and estrogen receptor (ER)+ (<jats:italic>P </jats:italic>= .027) or progesterone receptor (PR)+ (<jats:italic>P</jats:italic> = .002) tumors. On multivariate analysis (receiver operating characteristic curve area = 0.75), PR + status (<jats:italic>P</jats:italic> = .022), and older age (<jats:italic>P</jats:italic> = .004) were predictive of CBC.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Preoperative MRI is most effective in detecting early stage, hormone receptor‐positive CBC in older women.</jats:p></jats:sec>
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spelling Susnik, Barbara Schneider, Lisa Swenson, Karen K. Krueger, Janet Braatz, Christina Lillemoe, Tamera Tsai, Michaela DeFor, Todd E. Knaack, Monica Rueth, Natasha 0022-4790 1096-9098 Wiley Oncology General Medicine Surgery http://dx.doi.org/10.1002/jso.25130 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Preoperative breast magnetic resonance imaging (B‐MRI) staging in newly diagnosed breast cancer increases detection of synchronous contralateral findings, but may result in false‐positive outcomes. This study objective was to identify women more likely of having mammographically occult, MRI detected contralateral breast cancer (CBC).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a retrospective review of patients who had preoperative B‐MRI prior to surgery from 2010 to 2015 and collected patient imaging and clinicopathologic data. Multivariate logistic regression was used to identify predictors of CBC.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>MRI resulted in contralateral findings in 201 of 1894 patients (10.6%). Overall 3.2% (60 of 1894) had synchronous CBC detected on B‐MRI. The majority of CBCs (n = 60) were stage 0 or IA (85.0%), hormone receptor positive (94.9%), human epidermal growth factor receptor 2 (HER2/neu) negative (89.7%), and low/intermediate pathological grade (87.2%). Women more likely to have CBC were older (<jats:italic>P</jats:italic> &lt; .001), had lobular index cancer (<jats:italic>P = </jats:italic>.03), and estrogen receptor (ER)+ (<jats:italic>P </jats:italic>= .027) or progesterone receptor (PR)+ (<jats:italic>P</jats:italic> = .002) tumors. On multivariate analysis (receiver operating characteristic curve area = 0.75), PR + status (<jats:italic>P</jats:italic> = .022), and older age (<jats:italic>P</jats:italic> = .004) were predictive of CBC.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Preoperative MRI is most effective in detecting early stage, hormone receptor‐positive CBC in older women.</jats:p></jats:sec> Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer? Journal of Surgical Oncology
spellingShingle Susnik, Barbara, Schneider, Lisa, Swenson, Karen K., Krueger, Janet, Braatz, Christina, Lillemoe, Tamera, Tsai, Michaela, DeFor, Todd E., Knaack, Monica, Rueth, Natasha, Journal of Surgical Oncology, Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?, Oncology, General Medicine, Surgery
title Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_full Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_fullStr Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_full_unstemmed Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_short Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
title_sort predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: can we target women more likely to have contralateral breast cancer?
title_unstemmed Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
topic Oncology, General Medicine, Surgery
url http://dx.doi.org/10.1002/jso.25130