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Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma
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| Zeitschriftentitel: | Journal of Surgical Oncology |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| In: | Journal of Surgical Oncology, 116, 2017, 4, S. 450-458 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Roh, Jong‐Lyel Park, Jun Woo Jeong, Junhyeop Gong, Gyungyup Cho, Kyung‐Ja Choi, Seung‐Ho Nam, Soon Yuhl Kim, Sang Yoon Roh, Jong‐Lyel Park, Jun Woo Jeong, Junhyeop Gong, Gyungyup Cho, Kyung‐Ja Choi, Seung‐Ho Nam, Soon Yuhl Kim, Sang Yoon |
|---|---|
| author |
Roh, Jong‐Lyel Park, Jun Woo Jeong, Junhyeop Gong, Gyungyup Cho, Kyung‐Ja Choi, Seung‐Ho Nam, Soon Yuhl Kim, Sang Yoon |
| spellingShingle |
Roh, Jong‐Lyel Park, Jun Woo Jeong, Junhyeop Gong, Gyungyup Cho, Kyung‐Ja Choi, Seung‐Ho Nam, Soon Yuhl Kim, Sang Yoon Journal of Surgical Oncology Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma Oncology General Medicine Surgery |
| author_sort |
roh, jong‐lyel |
| spelling |
Roh, Jong‐Lyel Park, Jun Woo Jeong, Junhyeop Gong, Gyungyup Cho, Kyung‐Ja Choi, Seung‐Ho Nam, Soon Yuhl Kim, Sang Yoon 0022-4790 1096-9098 Wiley Oncology General Medicine Surgery http://dx.doi.org/10.1002/jso.24713 <jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Stratification of extranodal extension (ENE) extent has the potential to improve the accuracy of risk estimations in papillary thyroid carcinoma (PTC). This study examined the prognostic importance of nodal factors, including ENE, in PTC patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study enrolled 2071 consecutive patients with treatment‐naïve PTC who underwent thyroidectomy between 2006 and 2010. Microscopic/macroscopic ENE was determined by pathological and operative findings. Univariate and multivariate analyses were used to identify the relationship of factors with recurrence and survival in all study patients and in the node‐positive subset.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 2071 patients, 975 (47.1%) had positive lymph nodes, and 271 (13.1%) and 70 (3.4%) had microscopic and macroscopic ENE, respectively. During a median follow‐up of 96 months, 114 (5.5%) patients had post‐treatment recurrence. Multivariate analyses showed that, in all patients, the number of positive nodes, lymph node ratio, ENE status, and ATA risk group were independent variables affecting recurrence (<jats:italic>P</jats:italic> < 0.05). T4 and macroscopic ENE were independent variables associated with shorter overall survival (<jats:italic>P</jats:italic> < 0.05). Macroscopic ENE was significantly associated with macroscopic extrathyroidal extension.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Macroscopic ENE has a significant adverse impact on recurrence and survival after treatment for PTC. ENE is considered a high risk factor for recurrence.</jats:p></jats:sec> Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma Journal of Surgical Oncology |
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Wiley, 2017 |
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Wiley, 2017 |
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| title |
Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_unstemmed |
Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_full |
Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_fullStr |
Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_full_unstemmed |
Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_short |
Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_sort |
extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| topic |
Oncology General Medicine Surgery |
| url |
http://dx.doi.org/10.1002/jso.24713 |
| publishDate |
2017 |
| physical |
450-458 |
| description |
<jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Stratification of extranodal extension (ENE) extent has the potential to improve the accuracy of risk estimations in papillary thyroid carcinoma (PTC). This study examined the prognostic importance of nodal factors, including ENE, in PTC patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study enrolled 2071 consecutive patients with treatment‐naïve PTC who underwent thyroidectomy between 2006 and 2010. Microscopic/macroscopic ENE was determined by pathological and operative findings. Univariate and multivariate analyses were used to identify the relationship of factors with recurrence and survival in all study patients and in the node‐positive subset.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 2071 patients, 975 (47.1%) had positive lymph nodes, and 271 (13.1%) and 70 (3.4%) had microscopic and macroscopic ENE, respectively. During a median follow‐up of 96 months, 114 (5.5%) patients had post‐treatment recurrence. Multivariate analyses showed that, in all patients, the number of positive nodes, lymph node ratio, ENE status, and ATA risk group were independent variables affecting recurrence (<jats:italic>P</jats:italic> < 0.05). T4 and macroscopic ENE were independent variables associated with shorter overall survival (<jats:italic>P</jats:italic> < 0.05). Macroscopic ENE was significantly associated with macroscopic extrathyroidal extension.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Macroscopic ENE has a significant adverse impact on recurrence and survival after treatment for PTC. ENE is considered a high risk factor for recurrence.</jats:p></jats:sec> |
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| author | Roh, Jong‐Lyel, Park, Jun Woo, Jeong, Junhyeop, Gong, Gyungyup, Cho, Kyung‐Ja, Choi, Seung‐Ho, Nam, Soon Yuhl, Kim, Sang Yoon |
| author_facet | Roh, Jong‐Lyel, Park, Jun Woo, Jeong, Junhyeop, Gong, Gyungyup, Cho, Kyung‐Ja, Choi, Seung‐Ho, Nam, Soon Yuhl, Kim, Sang Yoon, Roh, Jong‐Lyel, Park, Jun Woo, Jeong, Junhyeop, Gong, Gyungyup, Cho, Kyung‐Ja, Choi, Seung‐Ho, Nam, Soon Yuhl, Kim, Sang Yoon |
| author_sort | roh, jong‐lyel |
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| container_title | Journal of Surgical Oncology |
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| description | <jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Stratification of extranodal extension (ENE) extent has the potential to improve the accuracy of risk estimations in papillary thyroid carcinoma (PTC). This study examined the prognostic importance of nodal factors, including ENE, in PTC patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study enrolled 2071 consecutive patients with treatment‐naïve PTC who underwent thyroidectomy between 2006 and 2010. Microscopic/macroscopic ENE was determined by pathological and operative findings. Univariate and multivariate analyses were used to identify the relationship of factors with recurrence and survival in all study patients and in the node‐positive subset.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 2071 patients, 975 (47.1%) had positive lymph nodes, and 271 (13.1%) and 70 (3.4%) had microscopic and macroscopic ENE, respectively. During a median follow‐up of 96 months, 114 (5.5%) patients had post‐treatment recurrence. Multivariate analyses showed that, in all patients, the number of positive nodes, lymph node ratio, ENE status, and ATA risk group were independent variables affecting recurrence (<jats:italic>P</jats:italic> < 0.05). T4 and macroscopic ENE were independent variables associated with shorter overall survival (<jats:italic>P</jats:italic> < 0.05). Macroscopic ENE was significantly associated with macroscopic extrathyroidal extension.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Macroscopic ENE has a significant adverse impact on recurrence and survival after treatment for PTC. ENE is considered a high risk factor for recurrence.</jats:p></jats:sec> |
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| imprint | Wiley, 2017 |
| imprint_str_mv | Wiley, 2017 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161 |
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| spelling | Roh, Jong‐Lyel Park, Jun Woo Jeong, Junhyeop Gong, Gyungyup Cho, Kyung‐Ja Choi, Seung‐Ho Nam, Soon Yuhl Kim, Sang Yoon 0022-4790 1096-9098 Wiley Oncology General Medicine Surgery http://dx.doi.org/10.1002/jso.24713 <jats:sec><jats:title>Background and Objectives</jats:title><jats:p>Stratification of extranodal extension (ENE) extent has the potential to improve the accuracy of risk estimations in papillary thyroid carcinoma (PTC). This study examined the prognostic importance of nodal factors, including ENE, in PTC patients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study enrolled 2071 consecutive patients with treatment‐naïve PTC who underwent thyroidectomy between 2006 and 2010. Microscopic/macroscopic ENE was determined by pathological and operative findings. Univariate and multivariate analyses were used to identify the relationship of factors with recurrence and survival in all study patients and in the node‐positive subset.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 2071 patients, 975 (47.1%) had positive lymph nodes, and 271 (13.1%) and 70 (3.4%) had microscopic and macroscopic ENE, respectively. During a median follow‐up of 96 months, 114 (5.5%) patients had post‐treatment recurrence. Multivariate analyses showed that, in all patients, the number of positive nodes, lymph node ratio, ENE status, and ATA risk group were independent variables affecting recurrence (<jats:italic>P</jats:italic> < 0.05). T4 and macroscopic ENE were independent variables associated with shorter overall survival (<jats:italic>P</jats:italic> < 0.05). Macroscopic ENE was significantly associated with macroscopic extrathyroidal extension.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Macroscopic ENE has a significant adverse impact on recurrence and survival after treatment for PTC. ENE is considered a high risk factor for recurrence.</jats:p></jats:sec> Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma Journal of Surgical Oncology |
| spellingShingle | Roh, Jong‐Lyel, Park, Jun Woo, Jeong, Junhyeop, Gong, Gyungyup, Cho, Kyung‐Ja, Choi, Seung‐Ho, Nam, Soon Yuhl, Kim, Sang Yoon, Journal of Surgical Oncology, Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma, Oncology, General Medicine, Surgery |
| title | Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_full | Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_fullStr | Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_full_unstemmed | Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_short | Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_sort | extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| title_unstemmed | Extranodal extension of lymph node metastasis as a prognostic indicator of recurrence and survival in papillary thyroid carcinoma |
| topic | Oncology, General Medicine, Surgery |
| url | http://dx.doi.org/10.1002/jso.24713 |