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Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)

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Zeitschriftentitel: Journal of Surgical Oncology
Personen und Körperschaften: Kern, Alexander, Görgens, Heike, Dittert, Dag‐Daniel, Krüger, Stefan, Richter, Konrad Klaus, Schackert, Hans K., Saeger, Hans‐Detlev, Baretton, Gustavo, Pistorius, Steffen
In: Journal of Surgical Oncology, 104, 2011, 1, S. 59-65
Format: E-Article
Sprache: Englisch
veröffentlicht:
Wiley
Schlagwörter:
Oncology
General Medicine
Surgery
author_facet Kern, Alexander
Görgens, Heike
Dittert, Dag‐Daniel
Krüger, Stefan
Richter, Konrad Klaus
Schackert, Hans K.
Saeger, Hans‐Detlev
Baretton, Gustavo
Pistorius, Steffen
Kern, Alexander
Görgens, Heike
Dittert, Dag‐Daniel
Krüger, Stefan
Richter, Konrad Klaus
Schackert, Hans K.
Saeger, Hans‐Detlev
Baretton, Gustavo
Pistorius, Steffen
author Kern, Alexander
Görgens, Heike
Dittert, Dag‐Daniel
Krüger, Stefan
Richter, Konrad Klaus
Schackert, Hans K.
Saeger, Hans‐Detlev
Baretton, Gustavo
Pistorius, Steffen
spellingShingle Kern, Alexander
Görgens, Heike
Dittert, Dag‐Daniel
Krüger, Stefan
Richter, Konrad Klaus
Schackert, Hans K.
Saeger, Hans‐Detlev
Baretton, Gustavo
Pistorius, Steffen
Journal of Surgical Oncology
Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
Oncology
General Medicine
Surgery
author_sort kern, alexander
spelling Kern, Alexander Görgens, Heike Dittert, Dag‐Daniel Krüger, Stefan Richter, Konrad Klaus Schackert, Hans K. Saeger, Hans‐Detlev Baretton, Gustavo Pistorius, Steffen 0022-4790 1096-9098 Wiley Oncology General Medicine Surgery http://dx.doi.org/10.1002/jso.21905 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease‐free survival after curative resection of the primary tumor without adjuvant systemic therapy.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Paraffin‐embedded tumor sections of 95 GISTs were analyzed for KIT and PDGFRA expression by immunohistochemistry. PDGFRA expression was judged using a scoring system subdividing tumors in negative/weak and strong immunoreactivity groups. For mutation analysis, exons 9, 10, 11, 13, and 17 of <jats:italic>KIT</jats:italic> and exons 10, 12, 14, and 18 of <jats:italic>PDGFRA</jats:italic> were sequenced.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 95 R0‐resected GISTs, 69% showed strong PDGFRA immunoreactivity. Gastric GISTs revealed a significantly higher rate of strong PDGFRA immunoreactivity (<jats:italic>P</jats:italic> = 0.01) and longer DFS (<jats:italic>P</jats:italic> = 0.015) than GISTs of the small intestine. <jats:italic>KIT</jats:italic> mutations were detected in 43 of 63 (68.3%) completely sequenced cases while <jats:italic>PDGFRA</jats:italic> mutations were identified in 6 cases (10%). In multivariate analysis, neither KIT/PDGFRA expression nor mutational status of <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> were independent prognostic factors. Only mitotic rate predicted recurrence independently.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our data do not support the notion that expression of PDGFRA or mutations in <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> are independent prognostic factors after curative resection of primary GIST. J. Surg. Oncol. 2011;104:59–65. © 2011 Wiley‐Liss, Inc.</jats:p></jats:sec> Mutational status of <i>KIT</i> and <i>PDGFRA</i> and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs) Journal of Surgical Oncology
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title Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_unstemmed Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_full Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_fullStr Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_full_unstemmed Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_short Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_sort mutational status of <i>kit</i> and <i>pdgfra</i> and expression of pdgfra are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (gists)
topic Oncology
General Medicine
Surgery
url http://dx.doi.org/10.1002/jso.21905
publishDate 2011
physical 59-65
description <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease‐free survival after curative resection of the primary tumor without adjuvant systemic therapy.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Paraffin‐embedded tumor sections of 95 GISTs were analyzed for KIT and PDGFRA expression by immunohistochemistry. PDGFRA expression was judged using a scoring system subdividing tumors in negative/weak and strong immunoreactivity groups. For mutation analysis, exons 9, 10, 11, 13, and 17 of <jats:italic>KIT</jats:italic> and exons 10, 12, 14, and 18 of <jats:italic>PDGFRA</jats:italic> were sequenced.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 95 R0‐resected GISTs, 69% showed strong PDGFRA immunoreactivity. Gastric GISTs revealed a significantly higher rate of strong PDGFRA immunoreactivity (<jats:italic>P</jats:italic> = 0.01) and longer DFS (<jats:italic>P</jats:italic> = 0.015) than GISTs of the small intestine. <jats:italic>KIT</jats:italic> mutations were detected in 43 of 63 (68.3%) completely sequenced cases while <jats:italic>PDGFRA</jats:italic> mutations were identified in 6 cases (10%). In multivariate analysis, neither KIT/PDGFRA expression nor mutational status of <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> were independent prognostic factors. Only mitotic rate predicted recurrence independently.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our data do not support the notion that expression of PDGFRA or mutations in <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> are independent prognostic factors after curative resection of primary GIST. J. Surg. Oncol. 2011;104:59–65. © 2011 Wiley‐Liss, Inc.</jats:p></jats:sec>
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author Kern, Alexander, Görgens, Heike, Dittert, Dag‐Daniel, Krüger, Stefan, Richter, Konrad Klaus, Schackert, Hans K., Saeger, Hans‐Detlev, Baretton, Gustavo, Pistorius, Steffen
author_facet Kern, Alexander, Görgens, Heike, Dittert, Dag‐Daniel, Krüger, Stefan, Richter, Konrad Klaus, Schackert, Hans K., Saeger, Hans‐Detlev, Baretton, Gustavo, Pistorius, Steffen, Kern, Alexander, Görgens, Heike, Dittert, Dag‐Daniel, Krüger, Stefan, Richter, Konrad Klaus, Schackert, Hans K., Saeger, Hans‐Detlev, Baretton, Gustavo, Pistorius, Steffen
author_sort kern, alexander
container_issue 1
container_start_page 59
container_title Journal of Surgical Oncology
container_volume 104
description <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease‐free survival after curative resection of the primary tumor without adjuvant systemic therapy.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Paraffin‐embedded tumor sections of 95 GISTs were analyzed for KIT and PDGFRA expression by immunohistochemistry. PDGFRA expression was judged using a scoring system subdividing tumors in negative/weak and strong immunoreactivity groups. For mutation analysis, exons 9, 10, 11, 13, and 17 of <jats:italic>KIT</jats:italic> and exons 10, 12, 14, and 18 of <jats:italic>PDGFRA</jats:italic> were sequenced.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 95 R0‐resected GISTs, 69% showed strong PDGFRA immunoreactivity. Gastric GISTs revealed a significantly higher rate of strong PDGFRA immunoreactivity (<jats:italic>P</jats:italic> = 0.01) and longer DFS (<jats:italic>P</jats:italic> = 0.015) than GISTs of the small intestine. <jats:italic>KIT</jats:italic> mutations were detected in 43 of 63 (68.3%) completely sequenced cases while <jats:italic>PDGFRA</jats:italic> mutations were identified in 6 cases (10%). In multivariate analysis, neither KIT/PDGFRA expression nor mutational status of <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> were independent prognostic factors. Only mitotic rate predicted recurrence independently.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our data do not support the notion that expression of PDGFRA or mutations in <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> are independent prognostic factors after curative resection of primary GIST. J. Surg. Oncol. 2011;104:59–65. © 2011 Wiley‐Liss, Inc.</jats:p></jats:sec>
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spelling Kern, Alexander Görgens, Heike Dittert, Dag‐Daniel Krüger, Stefan Richter, Konrad Klaus Schackert, Hans K. Saeger, Hans‐Detlev Baretton, Gustavo Pistorius, Steffen 0022-4790 1096-9098 Wiley Oncology General Medicine Surgery http://dx.doi.org/10.1002/jso.21905 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to investigate if immunohistochemical expression and mutational status of KIT and PDGFRA in GISTs are associated with the clinical course and disease‐free survival after curative resection of the primary tumor without adjuvant systemic therapy.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Paraffin‐embedded tumor sections of 95 GISTs were analyzed for KIT and PDGFRA expression by immunohistochemistry. PDGFRA expression was judged using a scoring system subdividing tumors in negative/weak and strong immunoreactivity groups. For mutation analysis, exons 9, 10, 11, 13, and 17 of <jats:italic>KIT</jats:italic> and exons 10, 12, 14, and 18 of <jats:italic>PDGFRA</jats:italic> were sequenced.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 95 R0‐resected GISTs, 69% showed strong PDGFRA immunoreactivity. Gastric GISTs revealed a significantly higher rate of strong PDGFRA immunoreactivity (<jats:italic>P</jats:italic> = 0.01) and longer DFS (<jats:italic>P</jats:italic> = 0.015) than GISTs of the small intestine. <jats:italic>KIT</jats:italic> mutations were detected in 43 of 63 (68.3%) completely sequenced cases while <jats:italic>PDGFRA</jats:italic> mutations were identified in 6 cases (10%). In multivariate analysis, neither KIT/PDGFRA expression nor mutational status of <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> were independent prognostic factors. Only mitotic rate predicted recurrence independently.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our data do not support the notion that expression of PDGFRA or mutations in <jats:italic>KIT</jats:italic> or <jats:italic>PDGFRA</jats:italic> are independent prognostic factors after curative resection of primary GIST. J. Surg. Oncol. 2011;104:59–65. © 2011 Wiley‐Liss, Inc.</jats:p></jats:sec> Mutational status of <i>KIT</i> and <i>PDGFRA</i> and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs) Journal of Surgical Oncology
spellingShingle Kern, Alexander, Görgens, Heike, Dittert, Dag‐Daniel, Krüger, Stefan, Richter, Konrad Klaus, Schackert, Hans K., Saeger, Hans‐Detlev, Baretton, Gustavo, Pistorius, Steffen, Journal of Surgical Oncology, Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs), Oncology, General Medicine, Surgery
title Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_full Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_fullStr Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_full_unstemmed Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_short Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
title_sort mutational status of <i>kit</i> and <i>pdgfra</i> and expression of pdgfra are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (gists)
title_unstemmed Mutational status of KIT and PDGFRA and expression of PDGFRA are not associated with prognosis after curative resection of primary gastrointestinal stromal tumors (GISTs)
topic Oncology, General Medicine, Surgery
url http://dx.doi.org/10.1002/jso.21905