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Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa*
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| Zeitschriftentitel: | Journal of Medical Virology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Journal of Medical Virology, 65, 2001, 3, S. 463-469 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Odemuyiwa, Solomon O. Mulders, Mick N. Oyedele, Oluseyi I. Ola, Samuel O. Odaibo, Georgina N. Olaleye, David O. Muller, Claude P. Odemuyiwa, Solomon O. Mulders, Mick N. Oyedele, Oluseyi I. Ola, Samuel O. Odaibo, Georgina N. Olaleye, David O. Muller, Claude P. |
|---|---|
| author |
Odemuyiwa, Solomon O. Mulders, Mick N. Oyedele, Oluseyi I. Ola, Samuel O. Odaibo, Georgina N. Olaleye, David O. Muller, Claude P. |
| spellingShingle |
Odemuyiwa, Solomon O. Mulders, Mick N. Oyedele, Oluseyi I. Ola, Samuel O. Odaibo, Georgina N. Olaleye, David O. Muller, Claude P. Journal of Medical Virology Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* Infectious Diseases Virology |
| author_sort |
odemuyiwa, solomon o. |
| spelling |
Odemuyiwa, Solomon O. Mulders, Mick N. Oyedele, Oluseyi I. Ola, Samuel O. Odaibo, Georgina N. Olaleye, David O. Muller, Claude P. 0146-6615 1096-9071 Wiley Infectious Diseases Virology http://dx.doi.org/10.1002/jmv.2058 <jats:title>Abstract</jats:title><jats:p>Isolates of hepatitis B viruses were collected from 20 acute and chronic hepatitis patients in a highly endemic region of Nigeria. Sequencing classified the isolates to the <jats:italic>ayw4</jats:italic>, as they all contained the amino acid variations characteristic for that serotype. In the pre‐S2 region of five isolates, three to seven amino acids were deleted, suggesting that immune escape mutations previously associated only with chronic HBV infection may be observed also in acute disease. Phylogenetic analysis of the complete pre‐S2/S (large S) genes (831 nt) demonstrated that all the viruses belonged to the same genotype E. So far, no isolates of genotype E have been found in any other region of the world, including the Americas. This may suggest a relatively recent introduction of this genotype into humans and would explain the relatively low genetic diversity of viruses belonging to this genotype. One genotype E virus had been found previously in a chimpanzee, and viruses belonging to the CHIMP genotype are related to other genotype E viruses. These findings are compatible with a transmission of genotype E viruses from chimpanzees to humans. J. Med. Virol. 65:463–469, 2001. © 2001 Wiley‐Liss, Inc.</jats:p> Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* Journal of Medical Virology |
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| title |
Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_unstemmed |
Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_full |
Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_fullStr |
Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_full_unstemmed |
Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_short |
Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_sort |
phylogenetic analysis of new hepatitis b virus isolates from nigeria supports endemicity of genotype e in west africa* |
| topic |
Infectious Diseases Virology |
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http://dx.doi.org/10.1002/jmv.2058 |
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2001 |
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463-469 |
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<jats:title>Abstract</jats:title><jats:p>Isolates of hepatitis B viruses were collected from 20 acute and chronic hepatitis patients in a highly endemic region of Nigeria. Sequencing classified the isolates to the <jats:italic>ayw4</jats:italic>, as they all contained the amino acid variations characteristic for that serotype. In the pre‐S2 region of five isolates, three to seven amino acids were deleted, suggesting that immune escape mutations previously associated only with chronic HBV infection may be observed also in acute disease. Phylogenetic analysis of the complete pre‐S2/S (large S) genes (831 nt) demonstrated that all the viruses belonged to the same genotype E. So far, no isolates of genotype E have been found in any other region of the world, including the Americas. This may suggest a relatively recent introduction of this genotype into humans and would explain the relatively low genetic diversity of viruses belonging to this genotype. One genotype E virus had been found previously in a chimpanzee, and viruses belonging to the CHIMP genotype are related to other genotype E viruses. These findings are compatible with a transmission of genotype E viruses from chimpanzees to humans. J. Med. Virol. 65:463–469, 2001. © 2001 Wiley‐Liss, Inc.</jats:p> |
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| author | Odemuyiwa, Solomon O., Mulders, Mick N., Oyedele, Oluseyi I., Ola, Samuel O., Odaibo, Georgina N., Olaleye, David O., Muller, Claude P. |
| author_facet | Odemuyiwa, Solomon O., Mulders, Mick N., Oyedele, Oluseyi I., Ola, Samuel O., Odaibo, Georgina N., Olaleye, David O., Muller, Claude P., Odemuyiwa, Solomon O., Mulders, Mick N., Oyedele, Oluseyi I., Ola, Samuel O., Odaibo, Georgina N., Olaleye, David O., Muller, Claude P. |
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| description | <jats:title>Abstract</jats:title><jats:p>Isolates of hepatitis B viruses were collected from 20 acute and chronic hepatitis patients in a highly endemic region of Nigeria. Sequencing classified the isolates to the <jats:italic>ayw4</jats:italic>, as they all contained the amino acid variations characteristic for that serotype. In the pre‐S2 region of five isolates, three to seven amino acids were deleted, suggesting that immune escape mutations previously associated only with chronic HBV infection may be observed also in acute disease. Phylogenetic analysis of the complete pre‐S2/S (large S) genes (831 nt) demonstrated that all the viruses belonged to the same genotype E. So far, no isolates of genotype E have been found in any other region of the world, including the Americas. This may suggest a relatively recent introduction of this genotype into humans and would explain the relatively low genetic diversity of viruses belonging to this genotype. One genotype E virus had been found previously in a chimpanzee, and viruses belonging to the CHIMP genotype are related to other genotype E viruses. These findings are compatible with a transmission of genotype E viruses from chimpanzees to humans. J. Med. Virol. 65:463–469, 2001. © 2001 Wiley‐Liss, Inc.</jats:p> |
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| spelling | Odemuyiwa, Solomon O. Mulders, Mick N. Oyedele, Oluseyi I. Ola, Samuel O. Odaibo, Georgina N. Olaleye, David O. Muller, Claude P. 0146-6615 1096-9071 Wiley Infectious Diseases Virology http://dx.doi.org/10.1002/jmv.2058 <jats:title>Abstract</jats:title><jats:p>Isolates of hepatitis B viruses were collected from 20 acute and chronic hepatitis patients in a highly endemic region of Nigeria. Sequencing classified the isolates to the <jats:italic>ayw4</jats:italic>, as they all contained the amino acid variations characteristic for that serotype. In the pre‐S2 region of five isolates, three to seven amino acids were deleted, suggesting that immune escape mutations previously associated only with chronic HBV infection may be observed also in acute disease. Phylogenetic analysis of the complete pre‐S2/S (large S) genes (831 nt) demonstrated that all the viruses belonged to the same genotype E. So far, no isolates of genotype E have been found in any other region of the world, including the Americas. This may suggest a relatively recent introduction of this genotype into humans and would explain the relatively low genetic diversity of viruses belonging to this genotype. One genotype E virus had been found previously in a chimpanzee, and viruses belonging to the CHIMP genotype are related to other genotype E viruses. These findings are compatible with a transmission of genotype E viruses from chimpanzees to humans. J. Med. Virol. 65:463–469, 2001. © 2001 Wiley‐Liss, Inc.</jats:p> Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* Journal of Medical Virology |
| spellingShingle | Odemuyiwa, Solomon O., Mulders, Mick N., Oyedele, Oluseyi I., Ola, Samuel O., Odaibo, Georgina N., Olaleye, David O., Muller, Claude P., Journal of Medical Virology, Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa*, Infectious Diseases, Virology |
| title | Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_full | Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_fullStr | Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_full_unstemmed | Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_short | Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| title_sort | phylogenetic analysis of new hepatitis b virus isolates from nigeria supports endemicity of genotype e in west africa* |
| title_unstemmed | Phylogenetic analysis of new hepatitis B virus isolates from Nigeria supports endemicity of genotype E in West Africa* |
| topic | Infectious Diseases, Virology |
| url | http://dx.doi.org/10.1002/jmv.2058 |