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Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol...
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| Zeitschriftentitel: | Journal of Labelled Compounds and Radiopharmaceuticals |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Journal of Labelled Compounds and Radiopharmaceuticals, 33, 1993, 1, S. 45-60 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Ackland, M. J. Howard, M. R. Jacobsen, E. J. Secreast, S. L. Dring, L. G. Ackland, M. J. Howard, M. R. Jacobsen, E. J. Secreast, S. L. Dring, L. G. |
|---|---|
| author |
Ackland, M. J. Howard, M. R. Jacobsen, E. J. Secreast, S. L. Dring, L. G. |
| spellingShingle |
Ackland, M. J. Howard, M. R. Jacobsen, E. J. Secreast, S. L. Dring, L. G. Journal of Labelled Compounds and Radiopharmaceuticals Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry |
| author_sort |
ackland, m. j. |
| spelling |
Ackland, M. J. Howard, M. R. Jacobsen, E. J. Secreast, S. L. Dring, L. G. 0362-4803 1099-1344 Wiley Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry http://dx.doi.org/10.1002/jlcr.2580330107 <jats:title>Abstract</jats:title><jats:p>This paper describes the synthesis and characterisation of 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]‐[<jats:sup>14</jats:sup>C]‐ methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol and 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐[<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidinyl)‐1‐ piperazinyl]‐[<jats:sup>13</jats:sup>C]‐methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐ benzopyran‐6‐ol. Intermediates in the synthesis included R‐(+)‐[<jats:sup>13</jats:sup>C]‐Trolox®(R‐(+)‐6‐hydroxy‐2,5,7,8‐tetramethylchroman‐[2‐<jats:sup>13</jats:sup>C]‐carboxylic acid), [2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐barbituric acid, 2,4,6‐trichloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine, 2,6‐di‐pyrrolidinyl‐4‐chloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine and 4‐(1‐piperazinyl)‐2,6‐di‐1‐pyrrolidinyl‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐ pyrimidine.</jats:p> Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol Journal of Labelled Compounds and Radiopharmaceuticals |
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DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 |
| imprint |
Wiley, 1993 |
| imprint_str_mv |
Wiley, 1993 |
| issn |
0362-4803 1099-1344 |
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0362-4803 1099-1344 |
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English |
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ackland1993synthesisofcarbon14andcarbon13labelledr2426di1pyrrolidinyl4pyrimidinyl1piperazinylmethyl34dihydro2578tetramethyl2h1benzopyran6ol |
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1993 |
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Wiley |
| recordtype |
ai |
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ai |
| series |
Journal of Labelled Compounds and Radiopharmaceuticals |
| source_id |
49 |
| title |
Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_unstemmed |
Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_full |
Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_fullStr |
Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_full_unstemmed |
Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_short |
Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_sort |
synthesis of carbon‐14 and carbon‐13 labelled (r)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2h‐1‐benzopyran‐6‐ol |
| topic |
Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry |
| url |
http://dx.doi.org/10.1002/jlcr.2580330107 |
| publishDate |
1993 |
| physical |
45-60 |
| description |
<jats:title>Abstract</jats:title><jats:p>This paper describes the synthesis and characterisation of 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]‐[<jats:sup>14</jats:sup>C]‐ methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol and 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐[<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidinyl)‐1‐ piperazinyl]‐[<jats:sup>13</jats:sup>C]‐methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐ benzopyran‐6‐ol. Intermediates in the synthesis included R‐(+)‐[<jats:sup>13</jats:sup>C]‐Trolox®(R‐(+)‐6‐hydroxy‐2,5,7,8‐tetramethylchroman‐[2‐<jats:sup>13</jats:sup>C]‐carboxylic acid), [2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐barbituric acid, 2,4,6‐trichloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine, 2,6‐di‐pyrrolidinyl‐4‐chloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine and 4‐(1‐piperazinyl)‐2,6‐di‐1‐pyrrolidinyl‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐ pyrimidine.</jats:p> |
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| description | <jats:title>Abstract</jats:title><jats:p>This paper describes the synthesis and characterisation of 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]‐[<jats:sup>14</jats:sup>C]‐ methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol and 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐[<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidinyl)‐1‐ piperazinyl]‐[<jats:sup>13</jats:sup>C]‐methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐ benzopyran‐6‐ol. Intermediates in the synthesis included R‐(+)‐[<jats:sup>13</jats:sup>C]‐Trolox®(R‐(+)‐6‐hydroxy‐2,5,7,8‐tetramethylchroman‐[2‐<jats:sup>13</jats:sup>C]‐carboxylic acid), [2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐barbituric acid, 2,4,6‐trichloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine, 2,6‐di‐pyrrolidinyl‐4‐chloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine and 4‐(1‐piperazinyl)‐2,6‐di‐1‐pyrrolidinyl‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐ pyrimidine.</jats:p> |
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| imprint | Wiley, 1993 |
| imprint_str_mv | Wiley, 1993 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161 |
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| physical | 45-60 |
| publishDate | 1993 |
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| series | Journal of Labelled Compounds and Radiopharmaceuticals |
| source_id | 49 |
| spelling | Ackland, M. J. Howard, M. R. Jacobsen, E. J. Secreast, S. L. Dring, L. G. 0362-4803 1099-1344 Wiley Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry http://dx.doi.org/10.1002/jlcr.2580330107 <jats:title>Abstract</jats:title><jats:p>This paper describes the synthesis and characterisation of 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]‐[<jats:sup>14</jats:sup>C]‐ methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol and 2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐[<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidinyl)‐1‐ piperazinyl]‐[<jats:sup>13</jats:sup>C]‐methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐ benzopyran‐6‐ol. Intermediates in the synthesis included R‐(+)‐[<jats:sup>13</jats:sup>C]‐Trolox®(R‐(+)‐6‐hydroxy‐2,5,7,8‐tetramethylchroman‐[2‐<jats:sup>13</jats:sup>C]‐carboxylic acid), [2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐barbituric acid, 2,4,6‐trichloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine, 2,6‐di‐pyrrolidinyl‐4‐chloro‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐pyrimidine and 4‐(1‐piperazinyl)‐2,6‐di‐1‐pyrrolidinyl‐[2,5‐<jats:sup>13</jats:sup>C<jats:sub>2</jats:sub>]‐ pyrimidine.</jats:p> Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol Journal of Labelled Compounds and Radiopharmaceuticals |
| spellingShingle | Ackland, M. J., Howard, M. R., Jacobsen, E. J., Secreast, S. L., Dring, L. G., Journal of Labelled Compounds and Radiopharmaceuticals, Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol, Organic Chemistry, Spectroscopy, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Analytical Chemistry |
| title | Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_full | Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_fullStr | Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_full_unstemmed | Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_short | Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| title_sort | synthesis of carbon‐14 and carbon‐13 labelled (r)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2h‐1‐benzopyran‐6‐ol |
| title_unstemmed | Synthesis of carbon‐14 and carbon‐13 labelled (R)‐(−)‐2[[4‐(2,6‐di‐1‐pyrrolidinyl‐4‐pyrimidinyl)‐1‐piperazinyl]methyl]‐3,4‐dihydro‐2,5,7,8‐tetramethyl‐2H‐1‐benzopyran‐6‐ol |
| topic | Organic Chemistry, Spectroscopy, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Analytical Chemistry |
| url | http://dx.doi.org/10.1002/jlcr.2580330107 |