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Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide...
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| Zeitschriftentitel: | Journal of Labelled Compounds and Radiopharmaceuticals |
|---|---|
| Personen und Körperschaften: | , |
| In: | Journal of Labelled Compounds and Radiopharmaceuticals, 52, 2009, 4, S. 103-109 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Zhong, D. Lewin, Anita H. Zhong, D. Lewin, Anita H. |
|---|---|
| author |
Zhong, D. Lewin, Anita H. |
| spellingShingle |
Zhong, D. Lewin, Anita H. Journal of Labelled Compounds and Radiopharmaceuticals Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry |
| author_sort |
zhong, d. |
| spelling |
Zhong, D. Lewin, Anita H. 0362-4803 1099-1344 Wiley Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry http://dx.doi.org/10.1002/jlcr.1575 <jats:title>Abstract</jats:title><jats:p>Fluocinolone acetonide was tritiated by selective reduction of the 1,2‐double bond of the <jats:italic>O</jats:italic>‐protected analog under tritium, followed by re‐establishment of the 1,2‐double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8 Ci/mmol. Copyright © 2009 John Wiley & Sons, Ltd.</jats:p> Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide Journal of Labelled Compounds and Radiopharmaceuticals |
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Journal of Labelled Compounds and Radiopharmaceuticals |
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49 |
| title |
Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_unstemmed |
Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_full |
Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_fullStr |
Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_full_unstemmed |
Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_short |
Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_sort |
preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| topic |
Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry |
| url |
http://dx.doi.org/10.1002/jlcr.1575 |
| publishDate |
2009 |
| physical |
103-109 |
| description |
<jats:title>Abstract</jats:title><jats:p>Fluocinolone acetonide was tritiated by selective reduction of the 1,2‐double bond of the <jats:italic>O</jats:italic>‐protected analog under tritium, followed by re‐establishment of the 1,2‐double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8 Ci/mmol. Copyright © 2009 John Wiley & Sons, Ltd.</jats:p> |
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| description | <jats:title>Abstract</jats:title><jats:p>Fluocinolone acetonide was tritiated by selective reduction of the 1,2‐double bond of the <jats:italic>O</jats:italic>‐protected analog under tritium, followed by re‐establishment of the 1,2‐double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8 Ci/mmol. Copyright © 2009 John Wiley & Sons, Ltd.</jats:p> |
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| physical | 103-109 |
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| spelling | Zhong, D. Lewin, Anita H. 0362-4803 1099-1344 Wiley Organic Chemistry Spectroscopy Drug Discovery Radiology, Nuclear Medicine and imaging Biochemistry Analytical Chemistry http://dx.doi.org/10.1002/jlcr.1575 <jats:title>Abstract</jats:title><jats:p>Fluocinolone acetonide was tritiated by selective reduction of the 1,2‐double bond of the <jats:italic>O</jats:italic>‐protected analog under tritium, followed by re‐establishment of the 1,2‐double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8 Ci/mmol. Copyright © 2009 John Wiley & Sons, Ltd.</jats:p> Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide Journal of Labelled Compounds and Radiopharmaceuticals |
| spellingShingle | Zhong, D., Lewin, Anita H., Journal of Labelled Compounds and Radiopharmaceuticals, Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide, Organic Chemistry, Spectroscopy, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Analytical Chemistry |
| title | Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_full | Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_fullStr | Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_full_unstemmed | Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_short | Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_sort | preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| title_unstemmed | Preparation of high specific activity tritium labeled 6α,9,‐difluoro‐11β,21‐dihydroxy‐16α,17‐[(1‐methylethylidene)bis(oxy)]pregna‐1,4‐diene‐3,20‐one, fluocinolone acetonide |
| topic | Organic Chemistry, Spectroscopy, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Analytical Chemistry |
| url | http://dx.doi.org/10.1002/jlcr.1575 |