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Redox (phospho)lipidomics of signaling in inflammation and programmed cell death
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| Zeitschriftentitel: | Journal of Leukocyte Biology |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Journal of Leukocyte Biology, 106, 2019, 1, S. 57-81 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Oxford University Press (OUP)
|
| Schlagwörter: |
| author_facet |
Tyurina, Yulia Y St. Croix, Claudette M Watkins, Simon C Watson, Alan M Epperly, Michael W Anthonymuthu, Tamil S Kisin, Elena R Vlasova, Irina I Krysko, Olga Krysko, Dmitri V Kapralov, Alexandr A Dar, Haider H Tyurin, Vladimir A Amoscato, Andrew A Popova, Elena N Bolevich, Sergey B Timashev, Peter S Kellum, John A Wenzel, Sally E Mallampalli, Rama K Greenberger, Joel S Bayir, Hulya Shvedova, Anna A Kagan, Valerian E Tyurina, Yulia Y St. Croix, Claudette M Watkins, Simon C Watson, Alan M Epperly, Michael W Anthonymuthu, Tamil S Kisin, Elena R Vlasova, Irina I Krysko, Olga Krysko, Dmitri V Kapralov, Alexandr A Dar, Haider H Tyurin, Vladimir A Amoscato, Andrew A Popova, Elena N Bolevich, Sergey B Timashev, Peter S Kellum, John A Wenzel, Sally E Mallampalli, Rama K Greenberger, Joel S Bayir, Hulya Shvedova, Anna A Kagan, Valerian E |
|---|---|
| author |
Tyurina, Yulia Y St. Croix, Claudette M Watkins, Simon C Watson, Alan M Epperly, Michael W Anthonymuthu, Tamil S Kisin, Elena R Vlasova, Irina I Krysko, Olga Krysko, Dmitri V Kapralov, Alexandr A Dar, Haider H Tyurin, Vladimir A Amoscato, Andrew A Popova, Elena N Bolevich, Sergey B Timashev, Peter S Kellum, John A Wenzel, Sally E Mallampalli, Rama K Greenberger, Joel S Bayir, Hulya Shvedova, Anna A Kagan, Valerian E |
| spellingShingle |
Tyurina, Yulia Y St. Croix, Claudette M Watkins, Simon C Watson, Alan M Epperly, Michael W Anthonymuthu, Tamil S Kisin, Elena R Vlasova, Irina I Krysko, Olga Krysko, Dmitri V Kapralov, Alexandr A Dar, Haider H Tyurin, Vladimir A Amoscato, Andrew A Popova, Elena N Bolevich, Sergey B Timashev, Peter S Kellum, John A Wenzel, Sally E Mallampalli, Rama K Greenberger, Joel S Bayir, Hulya Shvedova, Anna A Kagan, Valerian E Journal of Leukocyte Biology Redox (phospho)lipidomics of signaling in inflammation and programmed cell death Cell Biology Immunology Immunology and Allergy |
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tyurina, yulia y |
| spelling |
Tyurina, Yulia Y St. Croix, Claudette M Watkins, Simon C Watson, Alan M Epperly, Michael W Anthonymuthu, Tamil S Kisin, Elena R Vlasova, Irina I Krysko, Olga Krysko, Dmitri V Kapralov, Alexandr A Dar, Haider H Tyurin, Vladimir A Amoscato, Andrew A Popova, Elena N Bolevich, Sergey B Timashev, Peter S Kellum, John A Wenzel, Sally E Mallampalli, Rama K Greenberger, Joel S Bayir, Hulya Shvedova, Anna A Kagan, Valerian E 1938-3673 0741-5400 Oxford University Press (OUP) Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1002/jlb.3mir0119-004rr <jats:title>Abstract</jats:title> <jats:p>In addition to the known prominent role of polyunsaturated (phospho)lipids as structural blocks of biomembranes, there is an emerging understanding of another important function of these molecules as a highly diversified signaling language utilized for intra- and extracellular communications. Technological developments in high-resolution mass spectrometry facilitated the development of a new branch of metabolomics, redox lipidomics. Analysis of lipid peroxidation reactions has already identified specific enzymatic mechanisms responsible for the biosynthesis of several unique signals in response to inflammation and regulated cell death programs. Obtaining comprehensive information about millions of signals encoded by oxidized phospholipids, represented by thousands of interactive reactions and pleiotropic (patho)physiological effects, is a daunting task. However, there is still reasonable hope that significant discoveries, of at least some of the important contributors to the overall overwhelmingly complex network of interactions triggered by inflammation, will lead to the discovery of new small molecule regulators and therapeutic modalities. For example, suppression of the production of AA-derived pro-inflammatory mediators, HXA3 and LTB4, by an iPLA2γ inhibitor, R-BEL, mitigated injury associated with the activation of pro-inflammatory processes in animals exposed to whole-body irradiation. Further, technological developments promise to make redox lipidomics a powerful approach in the arsenal of diagnostic and therapeutic instruments for personalized medicine of inflammatory diseases and conditions.</jats:p> Redox (phospho)lipidomics of signaling in inflammation and programmed cell death Journal of Leukocyte Biology |
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Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
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Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_full |
Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
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Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
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Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_short |
Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_sort |
redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
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Cell Biology Immunology Immunology and Allergy |
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http://dx.doi.org/10.1002/jlb.3mir0119-004rr |
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2019 |
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57-81 |
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<jats:title>Abstract</jats:title>
<jats:p>In addition to the known prominent role of polyunsaturated (phospho)lipids as structural blocks of biomembranes, there is an emerging understanding of another important function of these molecules as a highly diversified signaling language utilized for intra- and extracellular communications. Technological developments in high-resolution mass spectrometry facilitated the development of a new branch of metabolomics, redox lipidomics. Analysis of lipid peroxidation reactions has already identified specific enzymatic mechanisms responsible for the biosynthesis of several unique signals in response to inflammation and regulated cell death programs. Obtaining comprehensive information about millions of signals encoded by oxidized phospholipids, represented by thousands of interactive reactions and pleiotropic (patho)physiological effects, is a daunting task. However, there is still reasonable hope that significant discoveries, of at least some of the important contributors to the overall overwhelmingly complex network of interactions triggered by inflammation, will lead to the discovery of new small molecule regulators and therapeutic modalities. For example, suppression of the production of AA-derived pro-inflammatory mediators, HXA3 and LTB4, by an iPLA2γ inhibitor, R-BEL, mitigated injury associated with the activation of pro-inflammatory processes in animals exposed to whole-body irradiation. Further, technological developments promise to make redox lipidomics a powerful approach in the arsenal of diagnostic and therapeutic instruments for personalized medicine of inflammatory diseases and conditions.</jats:p> |
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| author | Tyurina, Yulia Y, St. Croix, Claudette M, Watkins, Simon C, Watson, Alan M, Epperly, Michael W, Anthonymuthu, Tamil S, Kisin, Elena R, Vlasova, Irina I, Krysko, Olga, Krysko, Dmitri V, Kapralov, Alexandr A, Dar, Haider H, Tyurin, Vladimir A, Amoscato, Andrew A, Popova, Elena N, Bolevich, Sergey B, Timashev, Peter S, Kellum, John A, Wenzel, Sally E, Mallampalli, Rama K, Greenberger, Joel S, Bayir, Hulya, Shvedova, Anna A, Kagan, Valerian E |
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| spelling | Tyurina, Yulia Y St. Croix, Claudette M Watkins, Simon C Watson, Alan M Epperly, Michael W Anthonymuthu, Tamil S Kisin, Elena R Vlasova, Irina I Krysko, Olga Krysko, Dmitri V Kapralov, Alexandr A Dar, Haider H Tyurin, Vladimir A Amoscato, Andrew A Popova, Elena N Bolevich, Sergey B Timashev, Peter S Kellum, John A Wenzel, Sally E Mallampalli, Rama K Greenberger, Joel S Bayir, Hulya Shvedova, Anna A Kagan, Valerian E 1938-3673 0741-5400 Oxford University Press (OUP) Cell Biology Immunology Immunology and Allergy http://dx.doi.org/10.1002/jlb.3mir0119-004rr <jats:title>Abstract</jats:title> <jats:p>In addition to the known prominent role of polyunsaturated (phospho)lipids as structural blocks of biomembranes, there is an emerging understanding of another important function of these molecules as a highly diversified signaling language utilized for intra- and extracellular communications. Technological developments in high-resolution mass spectrometry facilitated the development of a new branch of metabolomics, redox lipidomics. Analysis of lipid peroxidation reactions has already identified specific enzymatic mechanisms responsible for the biosynthesis of several unique signals in response to inflammation and regulated cell death programs. Obtaining comprehensive information about millions of signals encoded by oxidized phospholipids, represented by thousands of interactive reactions and pleiotropic (patho)physiological effects, is a daunting task. However, there is still reasonable hope that significant discoveries, of at least some of the important contributors to the overall overwhelmingly complex network of interactions triggered by inflammation, will lead to the discovery of new small molecule regulators and therapeutic modalities. For example, suppression of the production of AA-derived pro-inflammatory mediators, HXA3 and LTB4, by an iPLA2γ inhibitor, R-BEL, mitigated injury associated with the activation of pro-inflammatory processes in animals exposed to whole-body irradiation. Further, technological developments promise to make redox lipidomics a powerful approach in the arsenal of diagnostic and therapeutic instruments for personalized medicine of inflammatory diseases and conditions.</jats:p> Redox (phospho)lipidomics of signaling in inflammation and programmed cell death Journal of Leukocyte Biology |
| spellingShingle | Tyurina, Yulia Y, St. Croix, Claudette M, Watkins, Simon C, Watson, Alan M, Epperly, Michael W, Anthonymuthu, Tamil S, Kisin, Elena R, Vlasova, Irina I, Krysko, Olga, Krysko, Dmitri V, Kapralov, Alexandr A, Dar, Haider H, Tyurin, Vladimir A, Amoscato, Andrew A, Popova, Elena N, Bolevich, Sergey B, Timashev, Peter S, Kellum, John A, Wenzel, Sally E, Mallampalli, Rama K, Greenberger, Joel S, Bayir, Hulya, Shvedova, Anna A, Kagan, Valerian E, Journal of Leukocyte Biology, Redox (phospho)lipidomics of signaling in inflammation and programmed cell death, Cell Biology, Immunology, Immunology and Allergy |
| title | Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_full | Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_fullStr | Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_full_unstemmed | Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_short | Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_sort | redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| title_unstemmed | Redox (phospho)lipidomics of signaling in inflammation and programmed cell death |
| topic | Cell Biology, Immunology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/jlb.3mir0119-004rr |