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Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales)
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Zeitschriftentitel: | Zeitschrift für allgemeine Mikrobiologie |
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Personen und Körperschaften: | |
In: | Zeitschrift für allgemeine Mikrobiologie, 18, 1978, 6, S. 399-407 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Grimm, K. Grimm, K. |
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author |
Grimm, K. |
spellingShingle |
Grimm, K. Zeitschrift für allgemeine Mikrobiologie Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) Genetics Applied Microbiology and Biotechnology |
author_sort |
grimm, k. |
spelling |
Grimm, K. 0044-2208 Wiley Genetics Applied Microbiology and Biotechnology http://dx.doi.org/10.1002/jobm.19780180603 <jats:title>Abstract</jats:title><jats:p><jats:italic>Cystobacter</jats:italic> species strain CK 1 does not grow with more than 0.2 μg/ml acriflavine. Spontaneous two‐step mutants growing with 2 μg acriflavine per ml have been selected. One mutant (strain CK 3) was used to investigate the effect of repair inhibitors. Both strains exhibit pronounced shoulders in their UV dose curves of inactivation. Acriflavine (AF), coumarin (CU), and caffeine (CA) when incorporated in the post‐irradiation plating medium decreased survival of irradiated cells. Post‐treatment with 2 μg acriflavine/ml abolished the shoulder of the curve. Caffeine (1600 μg/ml) and coumarin (350 μg/ml) reduced it only to about 40%. It is concluded that probably two repair mechanisms are present.</jats:p><jats:p>Pre‐treatment of the cells with 2 μg acriflavine/ml for two hours before UV‐irradiation resulted in a constant dose enhancement factor of 1.9. The protective effect is increased with the time of treatment with acriflavine. This may indicate that pyrimidine dimers are responsible for UV‐inactivation.</jats:p> Evidence for repair of ultraviolet‐induced damage in <i>Cystobacter</i> species (<i>Myxobacterales</i>) Zeitschrift für allgemeine Mikrobiologie |
doi_str_mv |
10.1002/jobm.19780180603 |
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Online |
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Biologie Technik |
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1978 |
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Wiley |
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Zeitschrift für allgemeine Mikrobiologie |
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title |
Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_unstemmed |
Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_full |
Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_fullStr |
Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_full_unstemmed |
Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_short |
Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_sort |
evidence for repair of ultraviolet‐induced damage in <i>cystobacter</i> species (<i>myxobacterales</i>) |
topic |
Genetics Applied Microbiology and Biotechnology |
url |
http://dx.doi.org/10.1002/jobm.19780180603 |
publishDate |
1978 |
physical |
399-407 |
description |
<jats:title>Abstract</jats:title><jats:p><jats:italic>Cystobacter</jats:italic> species strain CK 1 does not grow with more than 0.2 μg/ml acriflavine. Spontaneous two‐step mutants growing with 2 μg acriflavine per ml have been selected. One mutant (strain CK 3) was used to investigate the effect of repair inhibitors. Both strains exhibit pronounced shoulders in their UV dose curves of inactivation. Acriflavine (AF), coumarin (CU), and caffeine (CA) when incorporated in the post‐irradiation plating medium decreased survival of irradiated cells. Post‐treatment with 2 μg acriflavine/ml abolished the shoulder of the curve. Caffeine (1600 μg/ml) and coumarin (350 μg/ml) reduced it only to about 40%. It is concluded that probably two repair mechanisms are present.</jats:p><jats:p>Pre‐treatment of the cells with 2 μg acriflavine/ml for two hours before UV‐irradiation resulted in a constant dose enhancement factor of 1.9. The protective effect is increased with the time of treatment with acriflavine. This may indicate that pyrimidine dimers are responsible for UV‐inactivation.</jats:p> |
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author | Grimm, K. |
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description | <jats:title>Abstract</jats:title><jats:p><jats:italic>Cystobacter</jats:italic> species strain CK 1 does not grow with more than 0.2 μg/ml acriflavine. Spontaneous two‐step mutants growing with 2 μg acriflavine per ml have been selected. One mutant (strain CK 3) was used to investigate the effect of repair inhibitors. Both strains exhibit pronounced shoulders in their UV dose curves of inactivation. Acriflavine (AF), coumarin (CU), and caffeine (CA) when incorporated in the post‐irradiation plating medium decreased survival of irradiated cells. Post‐treatment with 2 μg acriflavine/ml abolished the shoulder of the curve. Caffeine (1600 μg/ml) and coumarin (350 μg/ml) reduced it only to about 40%. It is concluded that probably two repair mechanisms are present.</jats:p><jats:p>Pre‐treatment of the cells with 2 μg acriflavine/ml for two hours before UV‐irradiation resulted in a constant dose enhancement factor of 1.9. The protective effect is increased with the time of treatment with acriflavine. This may indicate that pyrimidine dimers are responsible for UV‐inactivation.</jats:p> |
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imprint | Wiley, 1978 |
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source_id | 49 |
spelling | Grimm, K. 0044-2208 Wiley Genetics Applied Microbiology and Biotechnology http://dx.doi.org/10.1002/jobm.19780180603 <jats:title>Abstract</jats:title><jats:p><jats:italic>Cystobacter</jats:italic> species strain CK 1 does not grow with more than 0.2 μg/ml acriflavine. Spontaneous two‐step mutants growing with 2 μg acriflavine per ml have been selected. One mutant (strain CK 3) was used to investigate the effect of repair inhibitors. Both strains exhibit pronounced shoulders in their UV dose curves of inactivation. Acriflavine (AF), coumarin (CU), and caffeine (CA) when incorporated in the post‐irradiation plating medium decreased survival of irradiated cells. Post‐treatment with 2 μg acriflavine/ml abolished the shoulder of the curve. Caffeine (1600 μg/ml) and coumarin (350 μg/ml) reduced it only to about 40%. It is concluded that probably two repair mechanisms are present.</jats:p><jats:p>Pre‐treatment of the cells with 2 μg acriflavine/ml for two hours before UV‐irradiation resulted in a constant dose enhancement factor of 1.9. The protective effect is increased with the time of treatment with acriflavine. This may indicate that pyrimidine dimers are responsible for UV‐inactivation.</jats:p> Evidence for repair of ultraviolet‐induced damage in <i>Cystobacter</i> species (<i>Myxobacterales</i>) Zeitschrift für allgemeine Mikrobiologie |
spellingShingle | Grimm, K., Zeitschrift für allgemeine Mikrobiologie, Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales), Genetics, Applied Microbiology and Biotechnology |
title | Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_full | Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_fullStr | Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_full_unstemmed | Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_short | Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
title_sort | evidence for repair of ultraviolet‐induced damage in <i>cystobacter</i> species (<i>myxobacterales</i>) |
title_unstemmed | Evidence for repair of ultraviolet‐induced damage in Cystobacter species (Myxobacterales) |
topic | Genetics, Applied Microbiology and Biotechnology |
url | http://dx.doi.org/10.1002/jobm.19780180603 |