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Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma
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| Zeitschriftentitel: | Journal of Cellular Physiology |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Journal of Cellular Physiology, 235, 2020, 4, S. 3612-3625 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Wang, Liming Zhang, Xin Liu, Yang Xu, Shun Wang, Liming Zhang, Xin Liu, Yang Xu, Shun |
|---|---|
| author |
Wang, Liming Zhang, Xin Liu, Yang Xu, Shun |
| spellingShingle |
Wang, Liming Zhang, Xin Liu, Yang Xu, Shun Journal of Cellular Physiology Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma Cell Biology Clinical Biochemistry Physiology |
| author_sort |
wang, liming |
| spelling |
Wang, Liming Zhang, Xin Liu, Yang Xu, Shun 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29251 <jats:title>Abstract</jats:title><jats:p>The pivotal roles of long noncoding RNAs have been reported in various cancers. Recently, FBXL19‐AS1 was proposed to be involved in tumor progression. However, its role in lung adenocarcinoma (LUAD) remains elusive. In this study, we observed that FBXL19‐AS1 was significantly upregulated in LUAD tissues and high FBXL19‐AS1 expression in LUAD was associated with a poor prognosis. Nevertheless, miR‐203‐3p showed the opposite effect. Moreover, cell viability and apoptosis analysis revealed that FBXL19‐AS1 knockdown could arrest LUAD cells in G0/G1 phase and inhibit cell proliferation, migration and invasion in vitro and inhibited LUAD tumor progress in vivo. Mechanistically, we identified FBXL19‐AS1 could act as a miR‐203a‐3p sponge using dual‐luciferase reporter assay. In addition, we demonstrated that downregulation of miR‐203a‐3p reversed growth inhibition of LUAD cells caused by FBXL19‐AS1 knockdown. Finally, FBXL19‐AS1/miR‐203a‐3p axis was found to associate with baculoviral IAP repeat‐containing protein 5.1‐A‐like (survivin), distal‐less homeobox 5, E2F transcription factor 1, and zinc finger E‐box binding homeobox 2 to regulate metastasis in LUAD cells. This study reveals a significance and mechanism of FBXL19‐AS1 in LUAD proliferation and metastasis and offers a potential prognostic marker and a therapeutic target for patients with LUAD.</jats:p> Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma Journal of Cellular Physiology |
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Journal of Cellular Physiology |
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| title |
Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_unstemmed |
Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_full |
Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_fullStr |
Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_full_unstemmed |
Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_short |
Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_sort |
long noncoding rna fbxl19‐as1 induces tumor growth and metastasis by sponging mir‐203a‐3p in lung adenocarcinoma |
| topic |
Cell Biology Clinical Biochemistry Physiology |
| url |
http://dx.doi.org/10.1002/jcp.29251 |
| publishDate |
2020 |
| physical |
3612-3625 |
| description |
<jats:title>Abstract</jats:title><jats:p>The pivotal roles of long noncoding RNAs have been reported in various cancers. Recently, FBXL19‐AS1 was proposed to be involved in tumor progression. However, its role in lung adenocarcinoma (LUAD) remains elusive. In this study, we observed that FBXL19‐AS1 was significantly upregulated in LUAD tissues and high FBXL19‐AS1 expression in LUAD was associated with a poor prognosis. Nevertheless, miR‐203‐3p showed the opposite effect. Moreover, cell viability and apoptosis analysis revealed that FBXL19‐AS1 knockdown could arrest LUAD cells in G0/G1 phase and inhibit cell proliferation, migration and invasion in vitro and inhibited LUAD tumor progress in vivo. Mechanistically, we identified FBXL19‐AS1 could act as a miR‐203a‐3p sponge using dual‐luciferase reporter assay. In addition, we demonstrated that downregulation of miR‐203a‐3p reversed growth inhibition of LUAD cells caused by FBXL19‐AS1 knockdown. Finally, FBXL19‐AS1/miR‐203a‐3p axis was found to associate with baculoviral IAP repeat‐containing protein 5.1‐A‐like (survivin), distal‐less homeobox 5, E2F transcription factor 1, and zinc finger E‐box binding homeobox 2 to regulate metastasis in LUAD cells. This study reveals a significance and mechanism of FBXL19‐AS1 in LUAD proliferation and metastasis and offers a potential prognostic marker and a therapeutic target for patients with LUAD.</jats:p> |
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| author | Wang, Liming, Zhang, Xin, Liu, Yang, Xu, Shun |
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| description | <jats:title>Abstract</jats:title><jats:p>The pivotal roles of long noncoding RNAs have been reported in various cancers. Recently, FBXL19‐AS1 was proposed to be involved in tumor progression. However, its role in lung adenocarcinoma (LUAD) remains elusive. In this study, we observed that FBXL19‐AS1 was significantly upregulated in LUAD tissues and high FBXL19‐AS1 expression in LUAD was associated with a poor prognosis. Nevertheless, miR‐203‐3p showed the opposite effect. Moreover, cell viability and apoptosis analysis revealed that FBXL19‐AS1 knockdown could arrest LUAD cells in G0/G1 phase and inhibit cell proliferation, migration and invasion in vitro and inhibited LUAD tumor progress in vivo. Mechanistically, we identified FBXL19‐AS1 could act as a miR‐203a‐3p sponge using dual‐luciferase reporter assay. In addition, we demonstrated that downregulation of miR‐203a‐3p reversed growth inhibition of LUAD cells caused by FBXL19‐AS1 knockdown. Finally, FBXL19‐AS1/miR‐203a‐3p axis was found to associate with baculoviral IAP repeat‐containing protein 5.1‐A‐like (survivin), distal‐less homeobox 5, E2F transcription factor 1, and zinc finger E‐box binding homeobox 2 to regulate metastasis in LUAD cells. This study reveals a significance and mechanism of FBXL19‐AS1 in LUAD proliferation and metastasis and offers a potential prognostic marker and a therapeutic target for patients with LUAD.</jats:p> |
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| spelling | Wang, Liming Zhang, Xin Liu, Yang Xu, Shun 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29251 <jats:title>Abstract</jats:title><jats:p>The pivotal roles of long noncoding RNAs have been reported in various cancers. Recently, FBXL19‐AS1 was proposed to be involved in tumor progression. However, its role in lung adenocarcinoma (LUAD) remains elusive. In this study, we observed that FBXL19‐AS1 was significantly upregulated in LUAD tissues and high FBXL19‐AS1 expression in LUAD was associated with a poor prognosis. Nevertheless, miR‐203‐3p showed the opposite effect. Moreover, cell viability and apoptosis analysis revealed that FBXL19‐AS1 knockdown could arrest LUAD cells in G0/G1 phase and inhibit cell proliferation, migration and invasion in vitro and inhibited LUAD tumor progress in vivo. Mechanistically, we identified FBXL19‐AS1 could act as a miR‐203a‐3p sponge using dual‐luciferase reporter assay. In addition, we demonstrated that downregulation of miR‐203a‐3p reversed growth inhibition of LUAD cells caused by FBXL19‐AS1 knockdown. Finally, FBXL19‐AS1/miR‐203a‐3p axis was found to associate with baculoviral IAP repeat‐containing protein 5.1‐A‐like (survivin), distal‐less homeobox 5, E2F transcription factor 1, and zinc finger E‐box binding homeobox 2 to regulate metastasis in LUAD cells. This study reveals a significance and mechanism of FBXL19‐AS1 in LUAD proliferation and metastasis and offers a potential prognostic marker and a therapeutic target for patients with LUAD.</jats:p> Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma Journal of Cellular Physiology |
| spellingShingle | Wang, Liming, Zhang, Xin, Liu, Yang, Xu, Shun, Journal of Cellular Physiology, Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma, Cell Biology, Clinical Biochemistry, Physiology |
| title | Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_full | Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_fullStr | Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_full_unstemmed | Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_short | Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| title_sort | long noncoding rna fbxl19‐as1 induces tumor growth and metastasis by sponging mir‐203a‐3p in lung adenocarcinoma |
| title_unstemmed | Long noncoding RNA FBXL19‐AS1 induces tumor growth and metastasis by sponging miR‐203a‐3p in lung adenocarcinoma |
| topic | Cell Biology, Clinical Biochemistry, Physiology |
| url | http://dx.doi.org/10.1002/jcp.29251 |