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Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer
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| Zeitschriftentitel: | Journal of Cellular Physiology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Journal of Cellular Physiology, 235, 2020, 2, S. 993-1000 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Luo, Weiming Wang, Meng Liu, Juan Cui, Xuan Wang, Hui Luo, Weiming Wang, Meng Liu, Juan Cui, Xuan Wang, Hui |
|---|---|
| author |
Luo, Weiming Wang, Meng Liu, Juan Cui, Xuan Wang, Hui |
| spellingShingle |
Luo, Weiming Wang, Meng Liu, Juan Cui, Xuan Wang, Hui Journal of Cellular Physiology Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer Cell Biology Clinical Biochemistry Physiology |
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luo, weiming |
| spelling |
Luo, Weiming Wang, Meng Liu, Juan Cui, Xuan Wang, Hui 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29015 <jats:title>Abstract</jats:title><jats:p>Cervical cancer is a tumor with the second highest morbidity and mortality in the world, and it is also the most common cancer and the eighth lethal factor among malignant tumors in Chinese female. This study aimed to identify long noncoding RNAs (lncRNAs) that related to diagnosis and prognosis in cervical cancer to improve early diagnosis and treatment. First, we extracted transcriptome profilings of cervical cancer samples from the cancer genome atlas (TCGA) database, and then extracted the lncRNAs and mRNAs expression profiles. Based on the lncRNAs expression profiles of test set, we screened lncRNAs that related to progression of cervical cancer tumors. We found six lncRNAs associated with tumor progression in cervical cancer patients, in which five lncRNAs have highly similar expression patterns but the other one has the opposite expression pattern. We found that these six lncRNAs might be related to keratinization and immunity by enrichment analysis, and two of them (AC126474 and C5orf66‐AS1) were associated with prognosis in patients with cervical cancer. And these results were validated using the validation set. Overall, we identified six lncRNAs that played an important role in the development of cervical cancer, and two of them might be associated with the prognosis of cervical cancer, which provides new insight into the diagnosis and treatment of cervical cancer.</jats:p> Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer Journal of Cellular Physiology |
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| title |
Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_unstemmed |
Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_full |
Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_fullStr |
Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_full_unstemmed |
Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_short |
Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_sort |
identification of a six lncrnas signature as novel diagnostic biomarkers for cervical cancer |
| topic |
Cell Biology Clinical Biochemistry Physiology |
| url |
http://dx.doi.org/10.1002/jcp.29015 |
| publishDate |
2020 |
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993-1000 |
| description |
<jats:title>Abstract</jats:title><jats:p>Cervical cancer is a tumor with the second highest morbidity and mortality in the world, and it is also the most common cancer and the eighth lethal factor among malignant tumors in Chinese female. This study aimed to identify long noncoding RNAs (lncRNAs) that related to diagnosis and prognosis in cervical cancer to improve early diagnosis and treatment. First, we extracted transcriptome profilings of cervical cancer samples from the cancer genome atlas (TCGA) database, and then extracted the lncRNAs and mRNAs expression profiles. Based on the lncRNAs expression profiles of test set, we screened lncRNAs that related to progression of cervical cancer tumors. We found six lncRNAs associated with tumor progression in cervical cancer patients, in which five lncRNAs have highly similar expression patterns but the other one has the opposite expression pattern. We found that these six lncRNAs might be related to keratinization and immunity by enrichment analysis, and two of them (AC126474 and C5orf66‐AS1) were associated with prognosis in patients with cervical cancer. And these results were validated using the validation set. Overall, we identified six lncRNAs that played an important role in the development of cervical cancer, and two of them might be associated with the prognosis of cervical cancer, which provides new insight into the diagnosis and treatment of cervical cancer.</jats:p> |
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| author | Luo, Weiming, Wang, Meng, Liu, Juan, Cui, Xuan, Wang, Hui |
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| description | <jats:title>Abstract</jats:title><jats:p>Cervical cancer is a tumor with the second highest morbidity and mortality in the world, and it is also the most common cancer and the eighth lethal factor among malignant tumors in Chinese female. This study aimed to identify long noncoding RNAs (lncRNAs) that related to diagnosis and prognosis in cervical cancer to improve early diagnosis and treatment. First, we extracted transcriptome profilings of cervical cancer samples from the cancer genome atlas (TCGA) database, and then extracted the lncRNAs and mRNAs expression profiles. Based on the lncRNAs expression profiles of test set, we screened lncRNAs that related to progression of cervical cancer tumors. We found six lncRNAs associated with tumor progression in cervical cancer patients, in which five lncRNAs have highly similar expression patterns but the other one has the opposite expression pattern. We found that these six lncRNAs might be related to keratinization and immunity by enrichment analysis, and two of them (AC126474 and C5orf66‐AS1) were associated with prognosis in patients with cervical cancer. And these results were validated using the validation set. Overall, we identified six lncRNAs that played an important role in the development of cervical cancer, and two of them might be associated with the prognosis of cervical cancer, which provides new insight into the diagnosis and treatment of cervical cancer.</jats:p> |
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| spelling | Luo, Weiming Wang, Meng Liu, Juan Cui, Xuan Wang, Hui 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29015 <jats:title>Abstract</jats:title><jats:p>Cervical cancer is a tumor with the second highest morbidity and mortality in the world, and it is also the most common cancer and the eighth lethal factor among malignant tumors in Chinese female. This study aimed to identify long noncoding RNAs (lncRNAs) that related to diagnosis and prognosis in cervical cancer to improve early diagnosis and treatment. First, we extracted transcriptome profilings of cervical cancer samples from the cancer genome atlas (TCGA) database, and then extracted the lncRNAs and mRNAs expression profiles. Based on the lncRNAs expression profiles of test set, we screened lncRNAs that related to progression of cervical cancer tumors. We found six lncRNAs associated with tumor progression in cervical cancer patients, in which five lncRNAs have highly similar expression patterns but the other one has the opposite expression pattern. We found that these six lncRNAs might be related to keratinization and immunity by enrichment analysis, and two of them (AC126474 and C5orf66‐AS1) were associated with prognosis in patients with cervical cancer. And these results were validated using the validation set. Overall, we identified six lncRNAs that played an important role in the development of cervical cancer, and two of them might be associated with the prognosis of cervical cancer, which provides new insight into the diagnosis and treatment of cervical cancer.</jats:p> Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer Journal of Cellular Physiology |
| spellingShingle | Luo, Weiming, Wang, Meng, Liu, Juan, Cui, Xuan, Wang, Hui, Journal of Cellular Physiology, Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer, Cell Biology, Clinical Biochemistry, Physiology |
| title | Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_full | Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_fullStr | Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_full_unstemmed | Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_short | Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| title_sort | identification of a six lncrnas signature as novel diagnostic biomarkers for cervical cancer |
| title_unstemmed | Identification of a six lncRNAs signature as novel diagnostic biomarkers for cervical cancer |
| topic | Cell Biology, Clinical Biochemistry, Physiology |
| url | http://dx.doi.org/10.1002/jcp.29015 |