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lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway
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| Zeitschriftentitel: | Journal of Cellular Physiology |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Journal of Cellular Physiology, 235, 2020, 10, S. 7194-7203 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Jiang, Wenyang Kai, Jindan Li, Donghang Wei, Zhongheng Wang, Ying Wang, Wei Jiang, Wenyang Kai, Jindan Li, Donghang Wei, Zhongheng Wang, Ying Wang, Wei |
|---|---|
| author |
Jiang, Wenyang Kai, Jindan Li, Donghang Wei, Zhongheng Wang, Ying Wang, Wei |
| spellingShingle |
Jiang, Wenyang Kai, Jindan Li, Donghang Wei, Zhongheng Wang, Ying Wang, Wei Journal of Cellular Physiology lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway Cell Biology Clinical Biochemistry Physiology |
| author_sort |
jiang, wenyang |
| spelling |
Jiang, Wenyang Kai, Jindan Li, Donghang Wei, Zhongheng Wang, Ying Wang, Wei 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29618 <jats:title>Abstract</jats:title><jats:p>Lung cancer remains the leading cause of cancer‐related death all over the world. In spite of the great advances made in surgery and chemotherapy, the prognosis of lung cancer patients is poor. A substantial fraction of long noncoding RNAs (lncRNAs) can regulate various cancers. A recent study has reported that lncRNA HOXB‐AS3 plays a critical role in cancers. However, its biological function remains unclear in lung cancer progression. In the current research, we found HOXB‐AS3 was obviously elevated in NSCLC tissues and cells. Functional assays showed that inhibition of HOXB‐AS3 was able to repress A549 and H1975 cell proliferation, cell colony formation ability and meanwhile, triggered cell apoptosis. Furthermore, the lung cancer cell cycle was mostly blocked in the G1 phase whereas the cell ratio in the S phase was reduced. Also, A549 and H1975 cell migration and invasion capacity were significantly repressed by the loss of HOXB‐AS3. The PI3K/AKT pathway has been implicated in the carcinogenesis of multiple cancers. Here, we displayed that inhibition of HOXB‐AS3 suppressed lung cancer cell progression via inactivating the PI3K/AKT pathway. Subsequently, in vivo experiments were utilized in our study and it was demonstrated that HOXB‐AS3 contributed to lung cancer tumor growth via modulating the PI3K/AKT pathway. Overall, we implied that HOXB‐AS3 might provide a new perspective for lung cancer treatment via targeting PI3K/AKT.</jats:p> lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway Journal of Cellular Physiology |
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Wiley, 2020 |
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| title |
lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_unstemmed |
lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_full |
lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_fullStr |
lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_full_unstemmed |
lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_short |
lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_sort |
lncrna hoxb‐as3 exacerbates proliferation, migration, and invasion of lung cancer via activating the pi3k‐akt pathway |
| topic |
Cell Biology Clinical Biochemistry Physiology |
| url |
http://dx.doi.org/10.1002/jcp.29618 |
| publishDate |
2020 |
| physical |
7194-7203 |
| description |
<jats:title>Abstract</jats:title><jats:p>Lung cancer remains the leading cause of cancer‐related death all over the world. In spite of the great advances made in surgery and chemotherapy, the prognosis of lung cancer patients is poor. A substantial fraction of long noncoding RNAs (lncRNAs) can regulate various cancers. A recent study has reported that lncRNA HOXB‐AS3 plays a critical role in cancers. However, its biological function remains unclear in lung cancer progression. In the current research, we found HOXB‐AS3 was obviously elevated in NSCLC tissues and cells. Functional assays showed that inhibition of HOXB‐AS3 was able to repress A549 and H1975 cell proliferation, cell colony formation ability and meanwhile, triggered cell apoptosis. Furthermore, the lung cancer cell cycle was mostly blocked in the G1 phase whereas the cell ratio in the S phase was reduced. Also, A549 and H1975 cell migration and invasion capacity were significantly repressed by the loss of HOXB‐AS3. The PI3K/AKT pathway has been implicated in the carcinogenesis of multiple cancers. Here, we displayed that inhibition of HOXB‐AS3 suppressed lung cancer cell progression via inactivating the PI3K/AKT pathway. Subsequently, in vivo experiments were utilized in our study and it was demonstrated that HOXB‐AS3 contributed to lung cancer tumor growth via modulating the PI3K/AKT pathway. Overall, we implied that HOXB‐AS3 might provide a new perspective for lung cancer treatment via targeting PI3K/AKT.</jats:p> |
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| author | Jiang, Wenyang, Kai, Jindan, Li, Donghang, Wei, Zhongheng, Wang, Ying, Wang, Wei |
| author_facet | Jiang, Wenyang, Kai, Jindan, Li, Donghang, Wei, Zhongheng, Wang, Ying, Wang, Wei, Jiang, Wenyang, Kai, Jindan, Li, Donghang, Wei, Zhongheng, Wang, Ying, Wang, Wei |
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| description | <jats:title>Abstract</jats:title><jats:p>Lung cancer remains the leading cause of cancer‐related death all over the world. In spite of the great advances made in surgery and chemotherapy, the prognosis of lung cancer patients is poor. A substantial fraction of long noncoding RNAs (lncRNAs) can regulate various cancers. A recent study has reported that lncRNA HOXB‐AS3 plays a critical role in cancers. However, its biological function remains unclear in lung cancer progression. In the current research, we found HOXB‐AS3 was obviously elevated in NSCLC tissues and cells. Functional assays showed that inhibition of HOXB‐AS3 was able to repress A549 and H1975 cell proliferation, cell colony formation ability and meanwhile, triggered cell apoptosis. Furthermore, the lung cancer cell cycle was mostly blocked in the G1 phase whereas the cell ratio in the S phase was reduced. Also, A549 and H1975 cell migration and invasion capacity were significantly repressed by the loss of HOXB‐AS3. The PI3K/AKT pathway has been implicated in the carcinogenesis of multiple cancers. Here, we displayed that inhibition of HOXB‐AS3 suppressed lung cancer cell progression via inactivating the PI3K/AKT pathway. Subsequently, in vivo experiments were utilized in our study and it was demonstrated that HOXB‐AS3 contributed to lung cancer tumor growth via modulating the PI3K/AKT pathway. Overall, we implied that HOXB‐AS3 might provide a new perspective for lung cancer treatment via targeting PI3K/AKT.</jats:p> |
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| spelling | Jiang, Wenyang Kai, Jindan Li, Donghang Wei, Zhongheng Wang, Ying Wang, Wei 0021-9541 1097-4652 Wiley Cell Biology Clinical Biochemistry Physiology http://dx.doi.org/10.1002/jcp.29618 <jats:title>Abstract</jats:title><jats:p>Lung cancer remains the leading cause of cancer‐related death all over the world. In spite of the great advances made in surgery and chemotherapy, the prognosis of lung cancer patients is poor. A substantial fraction of long noncoding RNAs (lncRNAs) can regulate various cancers. A recent study has reported that lncRNA HOXB‐AS3 plays a critical role in cancers. However, its biological function remains unclear in lung cancer progression. In the current research, we found HOXB‐AS3 was obviously elevated in NSCLC tissues and cells. Functional assays showed that inhibition of HOXB‐AS3 was able to repress A549 and H1975 cell proliferation, cell colony formation ability and meanwhile, triggered cell apoptosis. Furthermore, the lung cancer cell cycle was mostly blocked in the G1 phase whereas the cell ratio in the S phase was reduced. Also, A549 and H1975 cell migration and invasion capacity were significantly repressed by the loss of HOXB‐AS3. The PI3K/AKT pathway has been implicated in the carcinogenesis of multiple cancers. Here, we displayed that inhibition of HOXB‐AS3 suppressed lung cancer cell progression via inactivating the PI3K/AKT pathway. Subsequently, in vivo experiments were utilized in our study and it was demonstrated that HOXB‐AS3 contributed to lung cancer tumor growth via modulating the PI3K/AKT pathway. Overall, we implied that HOXB‐AS3 might provide a new perspective for lung cancer treatment via targeting PI3K/AKT.</jats:p> lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway Journal of Cellular Physiology |
| spellingShingle | Jiang, Wenyang, Kai, Jindan, Li, Donghang, Wei, Zhongheng, Wang, Ying, Wang, Wei, Journal of Cellular Physiology, lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway, Cell Biology, Clinical Biochemistry, Physiology |
| title | lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_full | lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_fullStr | lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_full_unstemmed | lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_short | lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| title_sort | lncrna hoxb‐as3 exacerbates proliferation, migration, and invasion of lung cancer via activating the pi3k‐akt pathway |
| title_unstemmed | lncRNA HOXB‐AS3 exacerbates proliferation, migration, and invasion of lung cancer via activating the PI3K‐AKT pathway |
| topic | Cell Biology, Clinical Biochemistry, Physiology |
| url | http://dx.doi.org/10.1002/jcp.29618 |